Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1031 for “"Covalent"”.
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STUDY OF COVALENT AND NON COVALENT INTERACTIONS OF BIOPOLYMER BY MASS SPECTROMETRY
… methods directly detect ligand-target non covalent complexes in the gas phase and allow inference of affinity (and specificity) of the ligand-target interaction in solution [1, 2]. The identity of different complexes can be directly assessed as the mass of each molecule works as intrinsic …
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Gas-Phase Covalent And Non-Covalent Ion/ion Chemistry Of Biological Macromolecules
… area of ion/ion chemistry, while selective covalent modification represents a fairly new area of gas-phase chemistry. Gas-phase covalent chemistry is based on traditional solution phase organic chemistry.</p> <p>The work demonstrated in this dissertation greatly involves gas-phase covalent …
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Control of covalent and non-covalent presentation of biomolecules within collagen GAG scaffolds
… optimal conditions to control the levels of covalent and non-specific attachment of biotinylated Concanavalin A (ConA) via two distinct covalent patterning techniques: 1-ethyl-3-3-dimethylaminopropylcarbodiimide hydrochloride (EDC) crosslinking and benzophenone (BP) biophotolithography. The …
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Using Covalent and Non-Covalent Chemistry to Control Properties of Single -Walled Carbon Nanotubes
… mobility control is demonstrated via covalent functionalization with 4-hydroxybenzene diazonium and non-covalent functionalization with sodium cholate surfactant. Solution-phase solubility without surfactants can be achieved using high levels of covalent functionalization with aryl …
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Quantifying Cooperativity in Non-Covalent Networks
Non-covalent interactions are important in biological, material, systems, and supramolecular chemistry. Some quantification of cooperativity in networks of non-covalent interactions has been done in the literature, but these experiments are often complex and not easily applicable to many different …
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Photochemical harpoons: covalent labels for multi-protein complexes
… effective fluorescent labelling and a covalent interaction between the toxin analogue and the enzymes. The KATP channel opener, diazoxide displays marked cardioprotective effects and is reported to bind to mitochondrial KATP channels. However, the molecular structure of these channels …
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Regulation of Histone Covalent Modifications During Yeast Apoptosis
… mechanism that alters chromatin structure is the covalent modification of histones, which associates with DNA to form the nucleosome, the fundamental unit of chromatin. Phosphorylation of histone H2B at serine 14 (H2BS14ph), catalyzed by Mst1 kinase, has been linked to chromatin compaction during …
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Covalent DNA Modifications in Phage and Bacterial Dynamics
… restriction enzymes and CRISPR systems, and the covalent DNA modifications that neutralize them. Multiple targeted nucleases equip bacteria with an innate immune response against phage, and CRISPR systems provide an adaptive immune response. I report three main studies. 1) To study the human gut …
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Covalent Binding and other Mechanisms of Primaquine Toxicity
<p>A dose-dependent covalent binding of primaquine to mouse liver microsomal protein was found in both in vitro and in vivo studies. The binding in vitro was linear during the first 90 minutes of incubation and dependent on the concentration of mouse liver microsomal protein. The in vitro covalent …
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Covalent Post-Assembly Modification of Metal-Organic Capsules
… reaction as a method for inducing covalent post-assembly modification on imine-based metal-organic cages. This is an important step toward developing transformations in which a single external stimulus (for instance singlet oxygen or an electrophile such as TAD) may be used to …
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Modelling of defect states in covalent amorphous solids
This study consists of the tight binding molecular dynamics simulations, of the bulk and defect structures, in hydrogenated amorphous silicon. Emphasis is given to the systematic analysis of the changes in the network structures, which occur due to the incorporation of hydrogen, at different levels …
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Covalent end-immobilization of oligonucleotides onto solid surfaces
… Photolysis of psoralen crosslinkers covalently immobilized the dsDNA molecules to the oligo surface. The covalently end-attached dsDNA formed brush-like structures where the dsDNA strand could react under conditions resembling the natural solution-state found in vivo. This method …
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Study Of Covalent And Non-Covalent Interactions In Ternary Systems Involving: Metal/DNA-RNA/Protein, Where Metal = Platinum(II), Palladium(II)
… ternary systems can be broadly grouped into covalent and non-covalent. The first kind of interactions can lead to the irreversible transformation of the components in the system, while the second is thought to be reversible leading to transient states and fluxionality. Both kinds of …
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Modeling Nanofiltration Separation Mechanisms in Covalent Organic Framework Membranes
… challenge these goals. In this work, we apply covalent organic frameworks (COFs) as model NF membrane materials to demonstrate control over partitioning and transport mechanisms. We experimentally isolate and quantify steric and non-steric contributions to solute partitioning and transport in …
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Competition Between Different Non-Covalent Interactions in Cluster Ions
Non-covalent interactions are important in ionic systems, where ion-molecule interactions must compete with molecule-molecule interactions. This competition between different non-covalent interactions ultimately governs the behavior of many processes. In this Thesis, competing noncovalent …
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Utilising Non-Covalent Interactions in Developing Enantioselective Radical Transformations
… strategies for radical reactions, utilising non-covalent interactions to control the asymmetry of these processes. The first research chapter describes the use of chiral phosphoric acids to control the enantioselectivity in the reactions of α-amino radicals. Firstly, a Giese reaction with …
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