Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Coupling chemistry"”.
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Cross-Coupling Chemistry as a Tool for the Synthesis of Diverse Heterocyclic Systems and Natural Products
… the title 'The Palladium-catalysed Ullmann Cross-coupling Reaction: A Modern Variant on a Time-honored Process'. The second publication has the title 'Palladium-Catalyzed Ullmann Cross-Coupling of beta-Iodoenones and beta-Iodoacrylates with o-Halonitroarenes or o-Iodobenzonitriles and Reductive …
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Cross-Coupling Chemistry as a Tool for the Synthesis of Diverse Heterocyclic Systems and Natural Products
… the title 'The Palladium-catalysed Ullmann Cross-coupling Reaction: A Modern Variant on a Time-honored Process'. The second publication has the title 'Palladium-Catalyzed Ullmann Cross-Coupling of beta-Iodoenones and beta-Iodoacrylates with o-Halonitroarenes or o-Iodobenzonitriles and Reductive …
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STEREOSPECIFIC SUZUKI-MIYAURA CROSS-COUPLING OF CHIRAL BENZYLIC BORONIC ESTERS AND VINYL BROMIDES
The Suzuki-Miyaura cross-coupling reaction is a powerful method for the construction of carbon-carbon bonds in academia and industry. Despite extensive research in this area and the significance of the reaction, it is most often employed to prepare flat, Csp2-Csp2 bonds between two aryl groups. …
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Protein Synthesis and Bioconjugation for Design of Antimicrobial Conjugates
… conjugation method based on Pd-mediated cross-coupling chemistry to perform conjugation reactions under mild and dilute conditions that are amenable to most proteins. Together, these strategies have the potential to generate new and non-traditional antibiotics.
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
… Sixty compounds weresynthesised using amide coupling chemistry and their biological activity tested using varioustechniques: their ability to restore cell-cell contact growth inhibition in a RhoA-activated cellline; the general cytotoxicity was measured by their ability to inhibit the growth …
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Development of novel heterocyclic compounds as vascular targeting agents
… of cancer prevalence, carcinogenesis, and biochemistry. The main targets for cancer therapeutics are introduced along with in-depth look at cancer vasculature, tubulin binding agents and their mechanisms of action.In chapter two the development of the routes to the dibenzo[c,e]oxepine target …
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Late transition metal catalyzed C-N and C-C bond forming reactions
… exceptionally effective in the C-N, C-0, and C-C coupling procedures. For some substrate combinations, these palladium catalysts are effective for the room-temperature catalytic amination of aryl chlorides. These palladium catalysts are also highly effective for Suzuki coupling reactions of aryl …
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Development of N-Heterocyclic Carbenes as Organic Catalysts and Efficient Ligands in Palladium Mediated Transformations
… phosphines in transition metal catalyzed cross-coupling chemistry. The advantages of NHCs over phosphines include ease of handling, minimal toxicity, stability and powerful electron donating properties. Improvement of catalytic processes has become increasingly relevant in light of prospective …
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Synthesis and biological evaluation of auristatin-F recombinant antibody-drug conjugates for cancer therapy
… synthesis of two BG-linkers was followed by coupling to auristatin-F, a powerful microtubule poison, using both Cu(I)-catalysed cycloaddition and amide coupling chemistry. The BG-linkers each incorporated a noncleavable polyethylene glycol spacer, one of which included a dansyl fluorescent …
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Chemical Tagging of Surface Composition Gradients With Polystyrene Nanospheres and the Extracellular Matrix Protein Fibronectin for the Study of Cellular Migration
… describes the use of water-soluble carbodiimide coupling chemistry with a succinimide stabilizer to covalently bind polystyrene nanospheres and the protein fibronectin (FN) to thiol gradient surfaces. Fluorescently doped, carboxylic acid-modified nanospheres were reacted with gradients of an …
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Functionalized carbon surfaces for clean electrochemical energy systems
… supports was developed. Specifically, diazonium coupling chemistry to covalently attach molecularly defined moieties bearing a terpyridine (tpy) group onto the surface of carbon supports, followed by the introduction of Fe (or other transition metal) centers into anchored tpy groups. Pyridinic …
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Point-of-care immunoassay system using carbon nanotube labels
… of the CNTs was accomplished using EDC/Sulfo-NHS coupling chemistry. The adsorption of surfactant and antibodies were manipulated in order to optimize immunoassay detection capability based on electrical measurements. Following surface functionalization methods, CNTs as a sensing label were …
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Synthesis of the Natural Alkaloids Angustureine, Cuspareine, Galipeine, Galipinine using α-Aminocycloalkyl Copper Reagents
… using α-aminocycloalkyl cuprate cross-coupling chemistry as a synthetic exercise to expand the utility of this class of cuprate reagents.</p> <p> Initially the t-butylformamidine (TBF) functionalized tetrahydroquinoline (THQ-TBF) starting material was synthesized from …
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds
… palladium catalysis. Indeed, the Nobel Prize in Chemistry was awarded to Professor Akira Suzuki, along with Professors Richard Heck and Ei-ichi Negishi, in 2010 for their important contributions in palladium-catalyzed cross-coupling chemistry. Over the last 30 years, reports on organoboron …
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Adventures in polyene chemistry
… These new approaches involve sequences of cross-coupling reactions. Explorations into the chemical reactivity of these compounds have also been carried out. Chapter 1 is a review of the literature of multi C(sp2)-C(sp2) bond couplings involving alkene reaction partners. Chapter 2 explores the …
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Adventures in polyene chemistry
… These new approaches involve sequences of cross-coupling reactions. Explorations into the chemical reactivity of these compounds have also been carried out. Chapter 1 is a review of the literature of multi C(sp2)-C(sp2) bond couplings involving alkene reaction partners. Chapter 2 explores the …
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Fabrication, Characterization and Cellular Interactions of Keratin Nanomaterial Coatings for Implantable Percutaneous Prosthetics
… complexes coated onto Ti surfaces using silane coupling chemistry. Keratin has been used in other studies for its cell adhesion and differentiation properties, and it has been suggested that the Leu-Asp-Val (LDV) amino acid motif is the primary site responsible for cellular attachment. In the …
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Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology
… reacts autocatalytically and in a strictly 1:1 coupling chemistry with substrates that have been modified with benzylguanine (BG). Through genetic fusion of this self-labelling protein with a tumour targeting antibody, we developed a recombinant immunoconjugate able to carry BG-modified …
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Translational Incorporation of Unsaturated Amino Acids
… The elaboration of the modified protein by cross-coupling chemistry has been investigated. Overall the work presented in this thesis sheds insight on the theory of pre-translational oxidation of proteins and their possible implications in degenerative diseases. The use of cell-free protein …
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Translational Incorporation of Unsaturated Amino Acids
… The elaboration of the modified protein by cross-coupling chemistry has been investigated. Overall the work presented in this thesis sheds insight on the theory of pre-translational oxidation of proteins and their possible implications in degenerative diseases. The use of cell-free protein …
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