Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Cotranslational Translocation"”.
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Parallel effects of signal peptide hydrophobic core modifications on cotranslational translocation and posttranslational cleavage by purified signal peptidase
… PTH signal peptide and the effects on protein translocation and processing were examined in a mammalian cell-free system. Increasing the length of the core by 3 residues had little effect on translocation and processing of the mutant signal peptide by microsomal membranes. Decreasing the length …
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Structural Characterisation of the Mammalian SRP Receptor
… to the endoplasmic reticulum (ER) membrane for cotranslational translocation. This requires the specific interaction of the signal recognition particle (SRP), a ribonucleoprotein, with its receptor (SR). The eukaryotic SR is a heterodimeric protein consisting of SRα and SRβ which is anchored to …
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Investigating the Unique Mechanism of Action of CADA Analogs for Down-Modulating CD4, Sortilin, and ACE2
… human CD4 (hCD4) and blocking co-translational translocation of the nascent protein across the endoplasmic reticulum (ER) membrane, which prevents the entry of HIV virus into target cells. The key amino acid residues that are critical for sensitivity to CADA are glutamine (Q-15) and proline …