Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Cotranslational"”.
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Cotranslational Folding of CFTR
The life of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in the cell is dictated by its biogenesis, cellular trafficking, regulated function, and destruction. Cystic fibrosis (CF) is the direct result of perturbations in these processes. Treatment of CF mandates the …
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Parallel effects of signal peptide hydrophobic core modifications on cotranslational translocation and posttranslational cleavage by purified signal peptidase
Secretory proteins are targeted to the secretory pathway by an amino terminal extension sequence known as the signal peptide. Signal peptides contain a central core of uncharged amino acids that are usually hydrophobic in nature. The hydrophobic core of the parathyroid hormone (PTH) signal peptide …
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THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE
… Earlier studies are consistent with a cotranslational lipid-desorption model that requires microsomal triglyceride transfer protein (MTP) and results in the formation of a small, neutral lipid core-containing emulsion particle. However, controversy exists as to the nature of the …
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Structural Characterisation of the Mammalian SRP Receptor
… to the endoplasmic reticulum (ER) membrane for cotranslational translocation. This requires the specific interaction of the signal recognition particle (SRP), a ribonucleoprotein, with its receptor (SR). The eukaryotic SR is a heterodimeric protein consisting of SRα and SRβ which is anchored to …
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Dual Roles for NBR1 in Bone Remodelling and Autophagosomal Protein Degradation
… by the proteasome as eEFl A is involved in the cotranslational degradation of polyubiquitinated proteins. -- In bone, Nbrl was previously identified as a key regulator of osteoblast differentiation and activity. The work described in this thesis strengthened these observations and highlighted …
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Recoding: reprogrammed genetic decoding with an emphasis on antizyme regulatory frameshifting
… can modulate the rate of translation, protein cotranslational folding and localization. Some nascent peptides act in concert with small molecules such as polyamines or antibiotics to stall the ribosome. To these known nascent peptide effects we have added that of a stimulatory effect on the +1 …
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Mass Spectrometry-Based Characterization Of Chloroplast Protein Complexes And Clp Protease Function
… assembly factors and proteins involved in cotranslational modifications, targeting and folding.
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Membrane Domain of Plant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: Targeting, Topology, and Function
… HMGRs are targeted to microsomal membranes in a cotranslational fashion that does not involve cleavage of an N-terminal targeting peptide. Membrane topography of HMGR was revealed by protease protection studies, indicating that both tomato HMGRs span the membrane two times such that both the C- …
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Post-translational Insertion of a Small Tail-Anchored Protein into the Membrane of the Endoplasmic Reticulum
… reticulum (ER) either during synthesis (cotranslationally) or after their synthesis is completed (post-translationally). While the cotranslational pathway is well characterized, much less is known about a post-translational pathway for targeting and insertion of membrane proteins. In this …
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Investigating the Unique Mechanism of Action of CADA Analogs for Down-Modulating CD4, Sortilin, and ACE2
The small molecule cyclotriazadisulfonamide (CADA) has been found to inhibit the replication of human immunodeficiency virus (HIV) and human herpesvirus type 7 in cell cultures. It works by down-modulating human CD4 (hCD4) and blocking co-translational translocation of the nascent protein across …
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… of the proteomics data were consistent with a cotranslational model. We noted a positive correlation between ISGylation and translational activity (based on ribosome profiling), as well as a positive correlation between “dwell time” of nascent chains on polysomes and ISGylation. Further, …
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Mechanisms of multipass membrane protein biogenesis
A crucial aspect of cellular physiology is the ability of a single cell to remain autonomous and concentrate reagents to improve efficiency. Semi-permeable membranes facilitate autonomy via an outer barrier (plasma membrane) and enclose functional hubs (organelles) to efficiently carry out …