Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Corticotropin Releasing Hormone"”.
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Mediating role of corticotropin-releasing hormone (CRH) in anxiety and ischemia: Behavioural and physiological correlates
Corticotropin-releasing hormone (CRH) has been considered the quintessential 'stress' neuropeptide, as it mediates stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis and produces behavioural and autonomic responses analogous to natural stressors. However, the role of CRH in …
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Diverse Immune Responses Mediated by Beta-Adrenergic and Corticotropin-Releasing Hormone Receptors in a Model of Pneumococcal sepsis
… neuroendocrine factors, catecholamines and corticotropin-releasing hormone (CRH) on immune responses involved in the pathogenesis of Streptococcus pneumoniae (S. pneumoniae) infection implementing both in vitro and in vivo methodology. Dendritic cells play a pivotal role in antigen …
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Alterations of the Corticotropin Releasing Hormone Receptor System Following Early Life Stress and Ethanol Self-Administration in Rhesus Monkeys
… leading to a higher risk of alcohol abuse. Corticotropin-releasing hormone (CRH), a primary mediator of the stress response in the brain, plays a regulatory role in ethanol (EtOH) consumption. The goal of this thesis was to identify how ELS and EtOH drinking affected …
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Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (taeniopygia Guttata)
… circulating corticosterone, neural expression of corticotropin releasing hormone and glucocorticoid receptors, social preference and pair bonding using a model species uniquely suited to studying long-term, monogamous relationships.</p>
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Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone
… receptor 3 (5-HT3AR) interneurons enriched with corticotropin-releasing hormone (CRH), generated using these established frameworks. Molecular profiling using Translating Ribosome Affinity Purification (TRAP-seq) predicted an elegant, bimodal postsynaptic mechanism for CRH neuron modulation of …
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Lesioning of the Nucleus of the Hippocampal Commissure Followed by Food Deprivation Stress in Birds Demonstrates Simultaneous Involvement in both the Hypothalamo-Pituitary-Adrenal Axis and the Hypothalamo-Pituitary-Thyroid Axis
… response within vertebrates. Within the HPA axis corticotropin releasing hormone (CRH) is a major regulator and driving hormone. A structure named the nucleus of the hippocampal commissure (NHpC) has been found to contain CRH neurons and also these neurons respond to early food deprivation stress …
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Transcriptomic Profiling of Hypothalamic Kiss1 Neurons
… axis. Kisspeptins are crucial for gonadotropin releasing hormone (GnRH) secretion, and subsequently for puberty onset and reproductive function. In mice, two distinct populations of Kiss1 expressing neurons are predominant in areas of the hypothalamus implicated in the neuroendocrine regulation …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… hypothalamic nuclei by activating corticotropin-releasing hormone neurons responsible for sickness behavior and hypothermia. Once bacteria enter the bloodstream, an immune paradox occurs where host responses counteract the invading pathogen but also contribute to devastating organ …
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Spatial, temporal, and circuit-specific activation patterns of basolateral amygdala projection neurons during stress
… activation of BLA neurons expressing corticotropin-releasing hormone receptor type I (CRHR1), which, just like discrete circuits, does not influence HPA axis activity on its own. Together, this emphasizes the heterogeneity of BLA projection populations, while providing evidence that a …
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A central medullary circuit regulating REM sleep and pontine waves
… dorsomedial medulla (dmM) neurons expressing corticotropin-releasing-hormone (CRH) with a dual role in regulating both REM sleep and P-waves in mice. Calcium imaging revealed that dmM CRH neurons are selectively activated during REM sleep, and their activity within REM sleep episodes …
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Psychoneuroimmunology of Interleukin-10
… the following: IL-10 induces the production of corticotropin-releasing hormone (CRH) from the hypothalamus; IL-10 induces the production of adrenocorticotropic hormone (ACTH) from AtT-20 cells derived from pituitary; and IL-10 inhibits glucocorticoid (GCS) production in Y-1 cells in the presence …
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Role of testosterone in mediating prenatel ethanol effects on hypothalamic-pituitary-adrenal activity in male rats
… females, raising the possibility that gonadal hormones play a role in mediating ethanol effects on HPA function. To address this possibility, two studies were conducted to test the hypothesis that the differential alterations in HPA activity observed in E compared to control males are mediated, …
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Maternal High-Salt Diet During Pregnancy in Sprague Dawley Rats Programs Exaggerated Stress-Induced Blood Pressure and Heart Rate Responses in Adult Female Offspring
… were collected for in situ hybridization for corticotropin releasing hormone (CRH) and radioimmunoassay for corticosterone. In order to determine the contribution of gene expression to differences seen, total brain RNA was analyzed with microarray. Rats were injected with a ganglionic blocker …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… reflected an increase in hypothalamic corticotropin-releasing hormone (CRH). CRH protein and CRH mRNA at mid-gestation were similar to concentrations in fetal baboons of late gestation and were not altered in fetuses in which the mother was treated with estradiol. In conclusion, the …
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From youth to old age: therapeutic potential of microbiota interventions in the gut-brain-axis
… of the glucocorticoids receptors (Nr3c1) and corticotropin-releasing hormone (Crhr1) receptors in the amygdala of young mice. In an attempt to understand the mechanisms through which microbiota-targeted interventions exert the anti-aging effects, we used a model of premature ageing (ApoE …
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Identification and Characterization of Developmentally Regulated Components of the Stress Axis in Petromyzon Marinus
Genes resembling elements of the Corticotropin releasing hormone (CRH) receptor-ligand system (CRH system) have been identified in invertebrate species and suggest the CRH system has existed, in some form, for approximately a billion years. It is theorized that vertebrates inherited components of …
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Cortisol perturbation in the pathophysiology of septicaemia, complicated pregnancy and weight loss/obesity.
… apparatus which regulates production of adrenocorticotropin (ACTH) and contains a light–entrained intrinsic CNS driven diurnal rhythm. Cortisol participates in a regulatory mechanism where inflammatory cytokines stimulate cortisol release and cortisol in turn suppresses cytokine release. The …