Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Corticotrophin-releasing factor"”.
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Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon:Role of Corticotrophin-releasing factor
… we aimed to investigate the involvement of corticotrophin-releasing factor in these stress-related alterations. Eighteen adult rats were divided into 3 experimental groups: (1) a saline-pretreated non-stressed group, (2) a saline-pretreated stressed group, (3) an astressin-pretreated …
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Mapping the neural circuits that underlie metabolic vs. emotional regulation of food-seeking behavior
… thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited to respond to food cues during threat state. Then, we used anatomical tracing, chemogenetic and optogenetic manipulation to identify a neural circuit from the VMH via …
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Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy
… the mdx mice possibly through effects on stress factors such as corticotrophin-releasing factor (CRF). This antidepressant also reduced skeletal muscle inflammation and caused a reduction in circulating interleukin (IL)-6 levels. In the second and third studies, we specifically blocked IL-6 …
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Mast cells affect brain physiology and behavior
… Since mast cells are activated by stressors via corticotrophin releasing factor, it is surprising that no differences in the hypothalamic-pituitary-adrenal axis reactivity are seen between mast cell deficient mice and littermate controls. Instead, the effects of mast cells on anxiety behavior and …
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Investigating the molecular pharmacology of class A and B G protein-coupled receptors
… receptor (CLR), the Calcitonin receptor (CTR), corticotrophin-releasing factor receptor type 2 (CRFR2) and the growth hormone-releasing hormone receptor (GHRHR). For the A2AR, agonist-mediated cAMP production and β-arrestin recruitment is studied, as well as receptor internalisation. In …
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Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… systems such as oxytocin (OXT), corticotropin-releasing factor (CRF), and serotonin (5-HT) have demonstrated therapeutic potential in reducing alcohol-related behaviors. However, how these neuromodulators alter GABAergic transmission in the CeA and interact with alcohol, particularly at the …