Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Corticostriatal"”.
-
Modular organization of the primate corticostriatal system
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1996.
-
Dopamine Modulates Corticostriatal Inputs During Motor Command Signalilng
… neurons. Dopamine is a crucial modulator of corticostriatal activity and loss of its normal function plays an important role in the pathophysiology of Parkinson's disease. We hypothesize that the functional reorganization of the cortical inputs to the striatum following long-term dopamine …
-
Characterizing corticostriatal circuit function during performance of habitual action sequences
… task-related neuronal activity in the corticostriatal circuit. I found that, unlike in motor cortex, neurons in striatum did not respond simply to particular individual actions, but responded preferentially at the initiation and termination of learned action sequences. These experiments …
-
Peripheral Inflammation and Activity within Corticostriatal Reward Circuitry: Interactive Roles in Components of Anhedonia during Adolescence
… a specific focus on peripheral inflammation, corticostriatal reward circuitry, and their interaction, in adolescence. Adolescence is a developmental period marked by significant maturation in both reward-related brain function and immune system activity, rendering it a sensitive window for …
-
Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2
… crucial regulator of striatal synaptogenesis and corticostriatal inputs during striatal development, and has also been demonstrated to play a critical role in motor learning. Here we show that, in mice, overexpression of Foxp2 in the adult striatum of two models of HD leads to rescue of …
-
Functional organisation of behavioural inhibitory control mechanisms in cortico-basal ganglia circuitry: implications for stimulant use disorder.
… groups. Chapter 6 presents evidence that corticostriatal functional and effective connectivity in an overlapping network that includes the anterior cingulate and inferior frontal cortices as well as motor cortex, the subthalamic nucleus and dorsal striatum, is critical to stopping impulse …
-
Generation and Analysis of Gene-Targeted Mouse Models for Oppenheim's Early-Onset Dyt1 Dystonia
… receptors may be the cause of the elimination of corticostriatal long-term depression (LTD) also detected in KI mice. Further motor learning behavioral testing revealed a severe deficiency of motor skill adaptation in KI mice that may be correlated with the absence of LTD. KD mice that expressed …
-
The mGluR2/3 Agonist LY397268 Improves Morphometric and Behavioral Outcomes in R6/2 Huntington's Disease Mice
… by an agonist dampens glutamate release from corticostriatal terminals. Treatments that target excitoxicity and oxidative stress thus may improve some of the symptoms in HD patients and it is therefore logical to pursue therapies aimed in this direction. LY379268 is an inviting mGluR2/3 …
-
Cell Type-Specific Roles of FoxP Transcription Factors in Vocalization and Cognition
… and datasets to further our understanding of corticostriatal functions of FoxP2 and FoxP1 in vocal learning zebra finches (Chapter Seven). In light of these studies, I discuss their implications for understanding human disorders affecting speech and language, and I impart further hypotheses …
-
Role of Tyrosine Receptor Kinase B in the Development and Function of the Central Nervous System
… Mice lacking BDNF-TrkB signaling in the corticostriatal and nigrostriatal circuits displayed severe motor deficits and striatal degeneration reminiscent of the Huntington?disease. In contrast, specific ablation of TrkB from the striatal medium spiny neurons resulted in late-onset …
-
Behavioural and cellular basis of the vulnerability to develop compulsive heroin seeking habits
… pattern of cellular plasticity within corticostriatal networks, and are preceded by diverse cellular adaptations, especially in the striatum, in vulnerable individuals. Finally, chapter 6 further investigated the cellular specificity of the observed adaptations in experiments that …
-
Modeling the role of the basal ganglia in motor control and motor programming
… units as functioning as a hidden layer, using corticostriatal weights as the only tunable parameters, the adaptive BG network can develop the capacity to perform universal binary mappings. In this way, the model can simulate important features of procedural learning in human experiments. At the …
-
The Neural Underpinnings of Obsessive-Compulsive Disorder: From Adolescence to Adulthood
… excitation-inhibition (E/I) balance within corticostriatal circuits. This thesis builds directly on previous work in adult OCD, particularly the findings of Biria et al. (2023), which demonstrated altered glutamate and GABA concentrations in frontostriatal regions. A key innovation of the …
-
Hedonics, Reward Prediction, and Reinforcement Learning in Schizophrenia: Relationships to Anhedonia and Avolition
… given the role of dopaminergic influence on corticostriatal circuits in mediating reinforcement learning. Instead, there was some evidence for reduced cortical responses to choice execution among patients, and to positive feedback among those patients higher in anhedonia/avolition. Together, …
-
Role of the PI-3K/Akt and ERK pathways in phencyclidine-induced neurotoxicity in neonatal rats and the protection by lithium and BDNF
… and brain-derived neurotrophic factor (BDNF). In corticostriatal slice cultures, we found that lithium and BDNF, inhibited PCP-induced caspase-3 activation and DNA fragmentation in a concentration-dependent manner, respectively. Lithium and BDNF also prevented the inhibitory action of PCP on the …
-
The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
… exerts an inhibitory influence over the limbic-corticostriatal circuitry and has been implicated in modulating cocaine-evoked behaviors, may play a key role in the development and maintenance of behavioral sensitization. However, the sensitivity of 5-HT2CR is diminished after withdrawal from a …
-
The neurostructural effects of prenatal exposure to methamphetamine in an infant population in the Western Cape
… such effects are already measurable in neonates. Corticostriatal circuit changes may underlie the impaired executive function observed in prenatally exposed children, and suggest a specific mechanism of damage in dopaminergic-related circuits that is consistent with the neurotoxic actions of …
-
Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… in cortical axonal projections including corticostriatal, corticospinal, and corticothalamic tracts, and they show a variable loss of the corpus callosum. Neurogenesis and interneuron specification occur normally in the absence of SRF and the deficits in axonal projections were not due to …
-
Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… neocortex defined by genes Ntf3, Pdyn and Wfs1, corticostriatal neurons in layer 5a of lateral cortex expressing Etv1 and corticothalamic neurons in layer 6 of neocortex defined by Ntsr1 and Syt6. We generated translation profiles of actively translated mRNAs in the targeted cell types with …
-
Anatomical and Physiological Characterization of Striatal Activation of the Cerebral Cortex
… and striatum is important. The monosynaptic corticostriatal cir-cuit has been extensively studied. In contrast, due to the poly-synaptic nature of the connec-tions between the striatum and the cortex, how the striatum and striatal dopaminergic activi-ty each influences or feedbacks the …
Page 1 of 2