Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Corticospinal tract"”.
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Nano-based drug delivery systems: Targeting to corticospinal tract neurons for controlled release of therapeutics
… stability of BDNF derivatization, targeting to corticospinal tract (CST) upper motor neurons, and promotion of outgrowth of neuronal processes from release of the outgrowth promoting therapeutic, C3 transferase. Each SFNP construct stably bound between 68.2 and 74.7% of the initial amount of …
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Gene therapy for axon regeneration
… deliver transgenes into cortical neurons and the corticospinal tract, because regeneration of this neuronal pathway is a key event to restore motor function. One of the advantages of gene therapy is the local and long-term expression of transgenes following direct injection. To achieve a …
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Opioid Addiction Treatments During Pregnancy and Their Effects on Axonal Growth and Myelination in the Developing Central Nervous System
… spinal cord, we analyzed the corpus callosum and corticospinal tract at 16 days of age, just before the peak of myelination. Our results point to an important role of the opioid system in regulating early axo-glial interactions coordinating axonal growth and myelination. Moreover, in addition to …
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Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity
… anisotropy and mean diffusivity in the affected corticospinal tract. Asymmetric baseline sensorimotor network organization was predictive of a positive and continuous functional response to CIMT. Clinically correlated network reorganization provides further evidence of neuroplastic mechanisms …
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Mitochondrial response to axonal injury
… injected into primary motor cortex, to label the corticospinal tract (CST), of adult rats. The axons of the CST were then injured by dorsal column lesion at C4-C5. We found that mitochondria in injured CST axons near the injury site are fragmented and fragmentation of mitochondria persists for two …
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The contribution of reorganised motor pathways to recovery of arm and hand function after stroke
… changes in the connectivity and function of the corticospinal tract (CST) that are associated with improved motor performance in the recovering arm and hand. The study comprised four parts: 1. Task dependency of responses to TMS in recovered stroke patients. Eight patients, who had recovered some …
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Fine Motor Skills, Processing Speed, And White Matter Integrity Among Pediatric Brain Tumor Survivors Who Received Proton Radiotherapy
… as damage to microstructure of white matter tracts, which is measured through diffusion tensor imaging (DTI). Additionally, the neurotoxicity of XRT contributes to maladaptive neurocognitive function and quality of life. In recent decades, proton radiotherapy (PRT) has been theorized as a …
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Control of human motoneurones during voluntary contraction and fatigue
… common path of the central nervous system. The corticospinal tract conveys neural information from the motor cortex to motoneurones. This thesis focuses on the corticospinal control of human motoneurones during voluntary contraction and fatigue. First, output of motoneurones to corticospinal …
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The Rat as a Translational Model of Neurotrauma: Primary Somatosensory Input and Imaging Biomarker Validation Following Spinal Cord and Peripheral Nerve Injuries
… studies focused on higher order, complex, spinal tracts. Furthermore, questions remain on the best methods to track recovery following nerve graft or injury, as current diagnostic and prognostic clinical tools are limited. Diffusion MRI (dMRI) has the potential to classify nerve injury severity …
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Impacts of blood flow occlusion on the human neuromuscular system
… fatigue, the neuromuscular system, muscle contractile properties and motor unit firing rates, using a combination of electrical stimulation, transcranial magnetic stimulation, transmastoid stimulation, force production, and electromyography (EMG). Study one investigated whether BFO …
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Response of sensorimotor pathways of the spinal cord to injury and experimental treatments
… This lesion interrupts the main component of the corticospinal tract which descends in the ventromedial dorsal column and also interrupts the ascending collaterals of sensory fibres from forelimb nerves. In this study, changes in the function of both of these pathways were assessed by recording …
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Spontaneously Regenerative Corticospinal Neurons in Mice
… receives input from the motor cortex via the corticospinal tract (CST). The CST comprises corticospinal neuron (CSN) axons that begin in Layer 5b of motor cortex and can extend up to one meter to reach targets in the caudal spinal cord in humans. CSNs regulate the spinal cord's sensorimotor …
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Neuromuscular factors contributing to reductions in muscle force after repeated, high-intensity muscular efforts
… production during repeated, forceful muscle contractions, including those that occur in the occupational, clinical and athletic settings. Fatigue during such efforts is likely to result from disturbances to multiple processes in the nervous system and muscle. However, previous research examining …
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Studies of plasticity after neuronal injury
… was used to label a major motor pathway, the corticospinal tract, well as sensory neurons, and to visualise their terminals as SpH-labelled puncta. Using this tool, it will be possible to study synaptogenesis in a quantifiable manner, with the potential to study the activity of these new …
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Characterising changes in pathology and function in clinically relevant models of spinal cord injury and using chondroitinase ABC gene therapy to promote repair
… assessments revealed some improved corticospinal tract function below the level of the injury. Finally, LV-ChABC also resulted in neuroprotection and improved spinal conduction in a more severe model of thoracic contusion injury, illustrating the robust effects of ChABC gene therapy …
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Early Predictors of Post-stroke Motor Recovery
… of clinical measures and biomarkers extracted from clinical magnetic resonance imaging (MRI) would accurately predict level of PUE motor recovery post-stroke in patients who underwent acute inpatient rehabilitation (AR) post-stroke. The studies were conducted via retrospective chart …
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Contribution of microglial reactivity to olfactory ensheathing cell migration in vivo
… cells (OECs) are glial cells that are an attractive candidate for neural repair after spinal cord injury and for remyelination of axons in diseases such as multiple sclerosis. OECs appear to migrate within the adult mammalian central nervous system (CNS) in animal models of spinal cord …
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Inhibitory effect of subthreshold transcranial magnetic stimulation on the stretch-evoked long latency response of forearm muscles
… neural input to the muscles. The reticulospinal tract (RST) is a prominent secondary motor pathway, as it extends the function of the primary motor pathway, the corticospinal tract (CST). The RST is especially important for its involvement in locomotion, maintenance of posture, reaching, and …
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MR Susceptibility Mapping: Improved Quantification and Applications in Developmental Brain Imaging
… magnetic susceptibility at the periventricular corticospinal tract (CST), which may indicate an increase in the local myelin content after treatment. (3) This methodology was then applied to profile the myelin maturation pattern of the white matter fiber bundles in pediatric subjects. Results …
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