Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Corticobasal"”.
-
Synaptic loss in the primary tauopathies of Progressive Supranuclear Palsy and Corticobasal Degeneration
… of Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD). Both PSP and CBD are associated with an accumulation of 4-repeat tau in cortical and subcortical areas. As well as movement disorders, they impair cognitive function, even where there is minimal atrophy. …
-
Usefulness of [18F]-Deoxyglucose Positron Emission Tomography in Diagnosing the Patients with Corticobasal Degeneration
Backgrounds and OBJECTIVES: The corticobasal degeneration (CBD) is a neurodegenerative disease showing the progressive asymmetric extrapyramidal motor deficits, apraxia and cortical sensory loss. The asymmetric fronto-parietal cortical and subcortical hypometabolism was demonstrated in the previous …
-
Imaging Correlates of Heterogeneity in the Syndromes Associated with Frontotemporal Lobar Degeneration
… the Progressive Supranuclear Palsy Corticobasal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M-UK) and the Genetic Frontotemporal Dementia Initiative (GENFI). I describe characteristic differences in markers derived from task-free functional MRI and their …
-
Genetic Characterisation of Neurodegenerative disorders
… (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). On strong evidence that several genes may influence the development of sporadic neurodegenerative diseases, the genetic association approach was used in the work of this thesis to identify the multiple variants of …
-
Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
… (4R, Progressive supranuclear palsy, PSP; corticobasal degeneration, CBD; others), or a combination of 3R/4R tau aggregates (Alzheimer disease, AD; chronic traumatic encephalopathy, CTE; primary age-related tauopathy, PART). This work details several methods for the selective detection and …
-
Behavioural disinhibition in the syndromes associated with frontotemporal lobar degeneration
… aphasia, progressive supranuclear palsy and corticobasal syndrome. Multivariate analyses of clinical features and brain morphometry identified components that showed considerable overlap across the diagnostic groups. The transdiagnostic components of clinical features predicted neuropathology …
-
Connectivity biomarkers in neurodegenerative tauopathies
… Progressive Supranuclear Palsy (PSP) and the Corticobasal Syndrome (CBS), two parkinsonian disorders associated with accumulation of hyperphos- phorylated and abnormally folded tau protein. I contrast these two disorders with Parkinson’s disease (PD), which is associated with the accumulation …
-
Apathy and Impulsivity in Frontotemporal Lobar Degeneration Syndromes
… dementia, progressive supranuclear palsy and corticobasal syndrome. They cause substantial patient morbidity and carer distress, often coexist and are undertreated. Using data from the Pick’s disease and Progressive supranuclear palsy Prevalence and INcidence (PiPPIN) Study, I examine the …
-
Progression and variation of Progressive Supranuclear Palsy
… observational “Progressive Supranuclear Palsy-Corticobasal Syndrome-Multiple system atrophy study” (PROSPECT-M-UK). Finally, I identify structural correlates of survival. After an introduction to the issues and principal research questions (Chapter 1) and general methods (Chapter 2), I exploit …
-
Apathy and Impulsivity in Frontotemporal Lobar Degeneration
Apathy and Impulsivity in Frontotemporal Lobar Degeneration Ian Coyle-Gilchrist Frontotemporal Lobar Degeneration (FTLD) is pathologically heterogeneous group of degenerative diseases of the brain. While there are distinct and highly recognisable clinical syndromes associated with FTLD there is …