Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 136 for “"Cortical neurons"”.
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
… Using endosomes isolated from cultured primary neurons, we determined that the trafficking of APP from the endosomal membrane into internal vesicles of late endosome/multivesicular bodies (MVB) is dependent on Endosomal Sorting Complexes Required for Transport (ESCRT) machinery. This implied …
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Aging Lowers Pex5 Levels In Cortical Neurons In Male and Female Mouse Brains
… in a neuronal HD model compared to control neurons, indicating that mHtt expression amplified the peroxisomal degradation process. We also found that in the cortices of a presymptomatic HD mouse model, neuronal levels of PEX5, (a peroxisomal protein involved in clearance and homeostasis of …
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The Transcription Factor ATF5 Protects Cortical Neurons from Toxicity Induced by Prostaglandin J2
… associated with mitochondrial impairment in neurons remains to be elucidated. To decipher the regulatory mechanisms involved with mediating neuroprotection, the effect of ATF5 was examined on the mitochondrial dysfunction induced by the proinflammatory prostaglandin PGJ2 in rat cortical …
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Cellular and Synaptic Morphology of Golgi -Impregnated Cortical Neurons in Patients With Schizophrenia
… reveal that despite normal numbers of cortical neurons, patients exhibit anatomical reductions in synaptic connectivity. Prefrontal regions have been implicated as a site of vulnerability to pathophysiological alterations, while evidence of anatomical disturbances in other cortical …
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Regulation of Tau gene expression by Aβ and the amyloid precursosr protein in cultured cortical neurons
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
… changes in dendritic morphology of mouse visual cortical neurons at postnatal day 15 induced by eye opening and knocking down each of the two MAGUKs with small inhibitory RNAs (siRNAs). The changes I found include smaller cell bodies, increased frequency of dendritic branching, and a decrease in …
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Calcium Channel Dysfunction in Huntington’s Disease
… degeneration. The mechanism by which striatal neurons undergo selective degeneration is not fully understood, although studies have suggested several different intrinsic and extrinsic mechanisms involving early neuronal dysfunction in the cortex and striatum. One way in which cortical neuron …
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Differential Expression of Cell Adhesion Molecules by Neuronal Injury
… molecules(CAMs) are expressed in glial cells and neurons play critical roles in development and maintenance of nervous system. CAMs are reported that may be key molecular determinants in the response of the nervous system to injury. Therefore we are thought to that the expression of these CAMs is …
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Neuron-glial interactions in dendrite growth
Interactions between neurons and glia occupy a central role in many aspects of development, maintenance, and function of the central nervous system (CNS). A fundamental event in CNS development is the elaboration of two distinct neuronal processes, axons and dendrites. The overall aim of this …
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Gene therapy for axon regeneration
… cord has devastating consequences because adult neurons in the central nervous system (CNS) do not regenerate. Traumatic CNS injuries are a significant clinical problem and have life-changing consequences for patients. There are 130.000 new cases of spinal cord injury (SCI) per year worldwide and …
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ALTERNATIVE SPLICING AND PHOSPHORYLATION PROVIDE A MECHANISTIC BASIS FOR FUNCTIONAL SPECIALIZATION OF LSD1/KDM1 HISTONE DEMETHYLASE IN THE CENTRAL NERVOUS SYSTEM
… ones, which are dynamically regulated during cortical development. The neuro-specific variants, whose functional diversification partly relies on the phosphorylation status, contribute to the acquisition of neurite morphology in an exclusive way. The expression of LSD1 splice variants is …
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The Protective Effects of Memantine On The Morphology and Activity of Irradiated Dendritic Spines
… In this study, both Thy-1 YFP mice and cultured cortical neurons were used to investigate changes in dendritic spines after cortical neurons were irradiated. The results indicated that irradiation has long-term and acute effects on the cortical dendritic spines. A decline in the density of the …
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Spatial and temporal regulation of cerebral cortex development by the transcription factor pax6
… generation, migration and differentiation of cortical neurons. Cortical projection neurons originate from progenitors of the embryonic dorsal telencephalon. The transcription factor Pax6 is expressed in apical progenitors (APs) throughout corticogenesis in a rostro-lateralhigh to …
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Nitric oxide induces chromatin remodelling in the developing central nervous system
… involves precise connections between billions of neurons. This is achieved, at least in part, by the overproduction of neurons and the survival of a select few that compete for limited survival and growth promoting factors, such as neurotrophic factors. The neurotrophin brain-derived neurotrophin …
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The role of the extracellular matrix in neuronal development and perinatal brain injury
… the major scaffold of ECM structures around neurons, termed perineuronal nets (PNNs). Although HA and PNNs are important for neuronal function in the mature brain, the specific expression and functions of HA and PNNs in the developing CNS under physiological and pathophysiological conditions …
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The analysis of a mouse model of Lysosomal Storage Disorder uncovers a role for astrocyte dysfunction in neurodegeneration
… was sufficient to induce degeneration of cortical neurons in vivo, whereas other neuronal populations were spared. Furthermore, in an ex vivo co-culture assay, I observed that Sumf1<sup>-/-</sup> astrocytes failed to support the survival and function of wild type cortical neurons, …
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… we leverage hPSC technology by differentiating cortical neurons at scale to study the neurotropism of Herpes simplex virus-1 (HSV-1), Monkeypox virus (MPXV), Varicella zoster virus (VZV) and Influenza A viruses (IAV). Our comparative virology approach demonstrated a susceptibility and …
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