Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Cortical development"”.
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Vascular Endothelial Growth Factor In Cortical Development
… unique to mammalian evolution is the development of the neocortex. The neocortex is a highly ordered six-layered structure, the development of which is tightly regulated. The formation of the cortex is concomitantly dependent upon an outward expansion of the neuroepithelium, a tissue …
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Role of Laminin gamma 1 in Cortical Development
… disrupted in the nervous system. These mice show cortical developmental abnormalities including undulations in the embryonic cortical plate and resultant adult cortical layers and abnormal positioning of pyramidal neurons and interneurons. We have investigated the mechanisms underlying these …
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Cell Type-Specific Contributions of FOXP1 to Human Cortical Development
Pages vi-xv are misnumbered as pages v-xiv, pages 89-129 are misnumbered as pages 87-127, and pages 130-174 are misnumbered as pages 124-168.
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Characterization of CPG15 during cortical development and activity dependent plasticity
… cortex by sensory experience capable of inducing cortical plasticity. Using in situ hybridization, we monitored cgp15 expression in 4-week-old mouse barrel cortex after trimming all whiskers except D1. We found that cpgl5 expression is depressed in the deprived barrels and enhanced in the barrel …
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Regulation of Notch Ligands Dll1 and Jag1 by Pax6 during cortical development
… of complex gene regulatory networks involved in development. There is currently relatively little knowledge about the gene networks that these transcription factors control and how they exert their regulatory effects. The paired-box transcription factor Pax6 has been identified as a master …
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The Role of MeCP2 and FoxG1 in Embryonic Cortical Development: Implications for Autism Spectrum Disorders
… disorders (ASDs) represent a group of neurodevelopmental conditions characterized by impaired social interactions, communication difficulties, and repetitive behaviors. While the etiologies of ASDs are complex and heterogeneous, mounting evidence points to disrupted cortical development as a …
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Human induced pluripotent stem cell models of Rett Syndrome reveal deficits in early cortical development
Rett Syndrome (RTT) is a pervasive, X-linked neurodevelopmental disorder that predominantly affects girls. The clinical patient features of RTT are most commonly reported to emerge between the ages of 6-18 months and as such, RTT has largely been considered to be a postnatal disorder. The vast …
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The Brains of Babies: A Surface Based Approach To Study Cortical Development in Term and Preterm Human Infants
… that we improve our understanding of normal cortical development and develop tools to evaluate injury. Using a surface based approach we have characterized normal cortical development in healthy term infants and analyzed abnormalities associated with preterm birth. Accurate cortical surface …
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DECODING CELLULAR AND TEMPORAL VARIABILITY IN HUMAN CORTICAL DEVELOPMENT. INTEGRATING SINGLE-CELL TRANSCRIPTOMICS ACROSS DEVELOPMENTAL STAGES AND EXPERIMENTAL MODELS.
… complex brain functions. However, studying their development over decades has been technically challenging due to limitations in data access and representation. Recent advances in single-cell profiling have provided a wealth of data on fetal and adult human cortex cells, but extracting insights …
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Molecular Mechanisms Controlling the Development and Evolution of the Human Cerebral Cortex
… and human-specific changes in the patterns of cortical progenitor proliferation and differentiation during development. The relative inaccessibility of human and primate cortical development has however hindered the study of the molecular mechanisms which underly it and are responsible for …
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Neural Dynamics in the Developing Piriform Cortex of Awake Rats
Revealing the mystery of cortical development can help us understand how cortical circuits learn to process information. Recent work on the visual and somatosensory systems has shown that cortex learns to process information during the pre-critical period, mostly in the absence of sensory input. …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… repressing transcription during embryonic development. However, our understanding of how PRC2 dysfunction affects cortical development, and how WVS heterozygous mutations impact H3K27 trimethylation landscape and subsequent transcriptional changes, remains limited and primarily based on …
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Converging roles of neurodevelopment and Wnt signaling in neuropsychiatric disorders
… increasingly suggest that Wnt signaling and cortical development - in addition to other perturbations - may underlie the pathophysiology of multiple disorders. Furthermore, besides autism spectrum disorder, contribution of neurodevelopmental dysregulations to disease etiology in late-onset …
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The Role of Nogo-A During Development of the Chick Central Nervous System
… However, neuronal expression of Nogo-A during development suggests an additional role. Little is known about the putative functions of Nogo-A during embryonic development. To examine its potential role we isolated and analyzed the Nogo-A sequence in the chick, we localized its mRNA expression …
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Effects of prolonged mitosis on neural stem cells in vivo during development
… mitotic processes in neural stem cells during cortical development. Yet, how perturbed neural stem cell mitosis kinetics affects cell fate following neural stem cell division is not well understood. Our lab recently discovered prolonging mitosis of mouse neural progenitors, either ex vivo or in …
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Regionalized choroid plexus-cerebrospinal fluid factors and effect of DNA Ligase IV deficiency in the developing mammalian brain
Fundamental to mammalian brain development is the integration of cell intrinsic and extrinsic signals that direct the proliferation and differentiation of neural stem cells. Precise expression of transcription factors together with other intracellular components instruct progenitor cell fate, …
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INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
… cells generated from progenitors during early cortical development contribute to neuropsychiatric disorders. Genetic interventions are known to cause these disorders but underlying mechanism remains unclear. Human FEZ1 gene is associated with a few mental diseases. In this thesis, we seek to …
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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model
… importance in neural cells during early brain development. Genome maintenance occurs at two broad stages; surveillance during DNA replication and DNA damage repair in differentiating and mature cells. Neural cells are particularly sensitive to DNA strand breaks and defective DNA damage …
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
… have an important implication in synaptic development, learning, memory, and neuronal disorders. Previous studies have suggested that two membrane-associated guanylate kinase (MAGUK) family scaffolding proteins, SAP102 and PSD-95, are involved in the switch from predominance of NMDA …
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Molecular Mechanisms Regulating Fate Determination of Cerebral Cortex Precursors
During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neuronal circuitry, and subsequent matching of glial numbers and position to that circuitry. Multiple molecular mechanisms act in concert to …
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