Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Cortical Network"”.
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Subcortical Inputs Governing Cortical Network Activity
… of signal propagation as well as spontaneous network activity, which will constrain that propagation. This thesis characterizes the nature and mechanisms of awake cortical network dynamics, as well as the sources of sensory inputs in different cortical layers of the rat somatosensory system. …
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Tetraspanin KAI1/CD82 inhibits cell migration-related cellular events via reorganizing actin network
… events was accompanied by defects in actin cortical network and stress fiber formations. Notably, actin polymerization was attenuated by KAI1/CD82. Although Rac1 activity was diminished upon KAI1/CD82 expression, Rac1 could not rescue lamellipodia formation because Rac1 activity is not …
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Cortical Dynamics of Language
… the dynamical mechanisms supporting cortical network behavior will significantly advance the understanding of how both focal and disconnection injuries yield neurological deficits, informing the development of therapeutic approaches.</p>
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Spatio-temporal dynamics of spontaneous neural activity during the transition from slow oscillations to an awake-like state in isolated cortical networks
… understood; in particular, the role of the local cortical network in orchestrating this transition spatially. We devised a new statistical procedure based on the time-frequency decomposi- tion of multivariate signals to investigate the network activity dynamics during this liminal regime. Our …
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Cell-type specific cholinergic modulation of the cortex
… forebrain is implicated in modulating diverse neocortical functions including information processing, cortical plasticity, arousal and attention. To understand the physiological basis of these brain functions during cholinergic modulation, it is critical to identify the cortical circuit elements …
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Cholinergic Control of Cortical Circuit Activity
… role in the moment-to-moment control of ongoing cortical state transitions that occur during periods of wakefulness. Yet, the underlying circuit mechanisms of synaptic cholinergic function in the neocortex remain unclear. Moreover, acetylcholine continues to be widely viewed as a slow and diffuse …
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Anteromedial Thalamus Gates the Selection & Stabilization of Long-Term Memories
… from the hippocampus to a distributed cortical network, with the anterior cingulate cortex playing a central role in remote memory retrieval. However, little is known about the mechanisms responsible for coordinating this process. Additionally, the intermediate memory representations in …
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Alternating Current Stimulation for Essential Tremor
… research suggests the involvement of a complex network called the cerebello-thalamo-cortical network. This network includes the inferior olive nuclei, cerebellum, red nucleus, thalamus, and cerebral cortex. Tremor generation in essential tremor is believed to be linked to neurodegeneration, …
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Unique and shared roles of the prefrontal and posterior parietal cortex in cognitive functions
… the posterior parietal cortex are parts of the cortical network involved in attention, working-memory and executive function. The two areas share a number of similarities, although functional differences between the two have also been identified. A widely believed functional difference posits …
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Automated Brain Mapping to Evaluate the Relationship between Neurodegeneration, Cerebral Small Vessel Disease and Structural Covariance Network Disruption in Alzheimer's Disease
… to AD progression by disrupting structural brain networks that subserve complex cognitive routines. Therefore, the overarching aim of this dissertation is to determine the contribution of cerebral small vessel disease (SVD) versus coexistent neurodegeneration to brain network disruption in AD. The …
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From spatio-temporal data to a weighted and lagged network between functional domains: Applications in climate and neuroscience
… identifies well-known “resting state networks” as well as a few areas forming the backbone of the functional cortical network. Finally, we contrast the proposed methods to dimensionality reduction techniques (e.g., clustering PCA/ICA) and show their limitations.
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Embedding of synchronous spike activity in cortical networks
… justifying a closer inspection of the underlying network mechanisms. As one such model, synfire chains are special feed-forward subnetworks that allow for stable modes of propagation of synchronous pulses of neuronal spike activity. These chains were previously investigated in isolation, with only …
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Network mechanisms underlying susceptibility to helplessness and response to the antidepressant fluoxetine
… rat strain, 2) to identify the neural network effects of response and non-response to SSRI treatment using a stress-susceptible animal model, and 3) to determine the neurophysiologic correlates of helplessness susceptibility. This was examined via measurement of regional brain metabolic …
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Investigation of ultrastructural and mechanical properties of rat cortical bone using micro-CT, three-point bending testing, and the reference point indentation technique
… their corresponding treatments. Assessment of cortical bone morphology has been identified as an important aspect of overall bone quality as it contributes significantly to the mechanical strength of bone. In the first part of this study, rat cortical bone was assessed at different hierarchical …
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Spatiotemporal brain imaging
… analyze the spatiotemporal characteristics of a cortical network that is responsive to visual motion coherency. Finally, in epilepsy patients, I compare the non-invasive MEG localization of interictal spikes with verification from invasive recordings and surgical results. These studies, in both …
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Top-Down Control of Lateral Interactions in Visual Cortex
… correlations can affect the coding accuracy of a cortical network, we investigated how top-down processes of attention and perceptual task affect V1 noise correlations. We were able to study the noise correlation dynamics that were due to attentional shift separately from the changes due to the …
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Cortical Representation of Learning Social Interactions In Freely Moving Non-Human Primates
… spiking between visual and prefrontal cortical neurons, with coordinated V4-dlPFC cells contributing more to encoding of social variables within each area. These results are the first to demonstrate how the visual-frontal cortical network prioritizes relevant sensory information to …
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Plasticity of the cortical representation of finger extensors induced by paired associative stimulation
… associative plasticity of the human motor cortical representation with the use of noninvasive transcranial magnetic stimulation (TMS) paired with peripheral electrical stimulation. Paired Associative Stimulation (PAS) has grown in popularity because of its potential clinical applications. …
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Dynamics and precursor signs for phase transitions in neural systems
… traverse the critical threshold between distinct cortical states, both healthy and pathological? Specifically we are interested in sub-threshold neural behaviour immediately prior to state transition. We use theoretical neural modelling (single spiking neurons, a network of these, and a mean-field …
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The Diversity of Cortical Interneurons
… discrimination, and memory consolidation. The cortical interneurons are key elements of the cortical system. These interneurons stabilize networks, but at the same time they also add non-linear effects to the excitatory system to make the cortical network more dynamic. To achieve this, cortical …
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