Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Correlates of protection"”.
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Study of the Immune Correlates of Protection in Rhesus Macaques Vaccinated against Simian Immunodeficiency Virus
… III vaccine clinical trial provided evidence of protection from virus infection, with 31.2% of the patients protected at three years since the end of the immunisation phase. Statistical analyses support serum IgG antibody recognition of the V2 region of viral gp120 as a mechanism of protection …
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Understanding the importance of vaccine formulation in generating protective immune responses against Leishmania amazonensis challenge
Leishmaniasis presents with a broad range of clinical manifestations and is caused by infection with Leishmania parasites. The life-long immunity found in individuals who naturally healed their infections suggests that development of a vaccine in feasible, although there is not one yet approved for …
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Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples
The biological correlates of protection against HIV infection remain poorly characterized, hindering the development of an effective prevention strategy. Studies of individuals who resist HIV infection or progress more slowly after being infected are important for the conception of appropriate …
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Correlates of risk of TB disease in infants with differential response to BCG vaccination
Studying prospective immune correlates of risk of TB disease following BCG vaccination is an important first step towards determining correlates of protection against TB, which can be identified only in a placebo-controlled randomized controlled trial (RCT) of an effective vaccine. To study …
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Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovis DeltaRD1
The development of improved vaccines against tuberculosis (TB) is directly linked to the investigation of new and better correlates of protection after vaccination against TB. Cloning and characterization of bovine homologues of the antimicrobial protein granulysin (Bo-lysin) and perforin by our …
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The Role of Antibodies to <i>Plasmodium falciparum</i> Merozoite Antigens in the Resistance of Young Infants to Febrile Malaria and Their Place as a Biomarker in the Detection of Malaria Transmission Hotspots
… vaccine development is hampered by the lack of reliable immune correlates of protection. We have analysed antibody responses in relation to the incidence of febrile malaria in young children, with the specific objective of investigating their contribution to the apparent resistance of young …
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Identifying Immunological Signatures in Blood Predictive of Host Response to Plasmodium Falciparum Vaccines and Infections Using Computational Methods
… it difficult to identify specific mechanisms of vaccine-induced and naturally acquired immunity. After more than half a century of research into potential immunization methods, reliable immune correlates of malaria protection still have yet to be identified, and questions underlying the …
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Genetic diversity of subtype C HIV-1 env variants in peripheral blood mononuclear cell (PBMC) DNA from infected mother-child pairs : a comparison of Heteroduplex Mobility Assay (HMA) and Base Excision Sequence Scanning (BESS) methods
… antigenic changes seen over time. The monitoring of changes in viral sequences can provide important information on the nature of the immune response and the correlates of protection. Viral diversification may also occur due to other selective pressures such as cell availability and differences in …
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Development of Tools to Quantitatively Probe Mycobacterium tuberculosis-induced Host Phagosomal and Signaling Responses
… tuberculosis (TB) remains a leading cause of infectious death, second only to COVID-19 in 2021. With over ten million new infections occurring every year, there remains an urgent need for an improved vaccine to reduce transmission and protect against TB complications. Additionally, the …
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Multivariate analysis of the immune response upon recent acquisition of Mycobacterium tuberculosis infection
… tuberculosis (M.tb), is the leading cause of mortality due to an infectious agent worldwide. Based on data from an adolescent cohort study carried out from May 2005 to February 2009, we studied and compared the immune responses of individuals from four cohorts that were defined based on …
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Identification of protective rickettsial antigens for vaccine development
The genus Rickettsia contains some of the most lethal pathogens known to man, including Rickettsia prowazekii, a select agent that could be used as a biological weapon. Although Rickettsia spp. cause important diseases of public health importance and there is a need to develop countermeasures for …
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Trichuris Muris Whey Acidic Protein Induces Type 2 Protective Immunity Against Whipworm
… representing the leading infectious cause of colitis and subsequent, inflammatory bowel disease (IBD). Current control measures focused on mass deworming have had limited success due to low drug efficacies. Vaccination would be an ideal, cost-effective strategy to induce protective …
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Immunological markers of protective immune reconstitution in HIV infected persons sensitised by Mycobacterium tuberculosis
Tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide and HIV-1 co-infection is the leading cause of susceptibility to tuberculosis. Sub-Saharan Africa has a high incidence of TB-HIV-1 coinfection and the risk of TB in HIV-1 infected people is increased at all …
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Antibody-omics for biomarker discovery in vaccinology and infectious diseases
… domain (Fc). While traditional methods of antibody profiling have successfully applied top-down approaches for mainly Fab analysis indicative of overall isotype titer, the Fc interactions between adaptive and innate immunity remain overlooked. As a result, a poorly defined antibody …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
… evaluate the sensitivity and assay applicability of these antibodies, I generated and purified antibody from two Hybridoma lines; NG3.5 and VE-4. To generate enough antibody for immunological assays, I grew large quantities of antibody-producing hybridoma cells and collected the supernatant. From …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
… evaluate the sensitivity and assay applicability of these antibodies, I generated and purified antibody from two Hybridoma lines; NG3.5 and VE-4. To generate enough antibody for immunological assays, I grew large quantities of antibody-producing hybridoma cells and collected the supernatant. From …
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Exploring the Polyclonal Antibody Responses Induced by Klebsiella pneumoniae Derived Outer-Membrane Vesicles
… for causing a disproportionate number of AMR-related deaths globally. These “ESKAPE” pathogens are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. Of these, Klebsiella pneumoniae stands out due to …
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Elucidating the Immunogenicity and Protective Immune Response of a Trivalent Vaccine for Sudan Ebola, Marburg, and Lassa Fever Viruses
… morbidity and mortality in overlapping regions of Africa. Despite millions of individuals in Africa being at risk of contracting an infection from one of these viruses, preventative measures are limited. Considering the challenges associated with production costs and delivery, particularly to …
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Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
… advances in scientific research and the advent of treatment and prevention strategies over the past several decades, the HIV/AIDS pandemic continues to pose a significant threat to public health. Nearly 40 million people are estimated to be living with HIV, with 1.5 million new infections in …