Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Coronaviruses"”.
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Host Entry Factors for Human Coronaviruses
<p>Coronaviruses infect a diverse range of animals from birds to pigs and cats to humans. Coronaviruses employ RNA-based replicative processes and as such are genetically adaptable to acquire novel host ranges. A coronavirus from one species can jump to another by shifting its entry requirements. …
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INFECTION- AND VACCINE-INDUCED IMMUNE RESPONSES TO SARS-COV-2 AND OTHER HUMAN CORONAVIRUSES
… cross-reactivity between the human common cold coronaviruses, OC43 and HKU1 while antibody cross-reactivity was minimal. HCW sample screening revealed universal seropositivity to human common cold coronaviruses, but low or undetectable T cell responses. Following in vitro expansion and epitope …
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Receptor Binding Domains and Coronavirus Adaptation and Evolution
Coronaviruses are enveloped RNA viruses that cause respiratory diseases in humans and other animals. The continued circulation of human coronaviruses and the large reservoir of non-human coronaviruses that have the potential to infect humans represent a significant health concern. Similar to other …
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Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to Detect Inhibition of Protease Activity and Separation of the Multiple Functions of Coronavirus Papain-Like Proteases
<p>Coronaviruses are important human pathogens and have the potential to severely impact public health on an international scale. The emergence of SARS-CoV and MERS-CoV highlight the need for research to identify antivirals and vaccines against coronaviruses. To develop therapeutics against current …
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The Interferon Stimulated Gene Product Lymphocyte Antigen 6 Complex, Locus E Promotes Entry of a Subset of Diverse RNA Viruses and Inhibits Infection by Coronaviruses
Interferons (IFNs) contribute to cell-intrinsic antiviral immunity by inducing hundreds of IFN-stimulated genes (ISG). In a screen to identify novel antiviral factors, the Schoggins lab unexpectedly uncovered a subset of genes that enhanced viral infection. Here, I describe my personal efforts to …
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Computational Methods to Design Broad-Spectrum Medical Countermeasures Against Antigenically Diverse Pathogens
… caused by rapidly mutating pathogens, such as coronaviruses and influenza viruses, pose substantial challenges for global health. Mutations in these pathogens can change their antigens—which are molecules recognised by T-cells and antibodies of the immune system. This antigenic diversity can …
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Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines
… of PLPs seems to be conserved among many coronaviruses. I demonstrated protease and deubiquitinase activity of PLP2s from HCoV-OC43, HCoV-229E, HCoV-HKU1, MHV and FIPV.</p><p>To evaluate the role of PLP during virus replication and pathogenesis I utilized two approaches and a mouse model …
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A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism
… respiratory tract infections. Infection with coronaviruses can cause disease ranging from common colds to severe acute respiratory syndrome. Currently no coronavirus-specific antivirals are available. Patients are given symptomatic treatment, or are prescribed inappropriately antibiotics which …
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Cloning and expression of the M-gene from the human coronavirus NL-63 in different expression systems
… metapneumo-, respiratory syncytial-, adeno- and coronaviruses), the cause of a substantial portion, (48-70%) of cases remain unidentified (Van der Hoek et al, 2004; Fouchier et al, 2004; File, 2003; Fine et al, 1999; Shay et al, 1999, Henrickson et al 2004; Murray et al 2001). In the past, human …
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Understanding the determinants for substrate recognition, regulation of enzymatic activity and the development of broad-spectrum inhibitors of coronavirus 3-chymotrypsin-like proteases
Coronaviruses include lethal human pathogens like severe acute respiratory syndrome coronavirus (SARS-CoV) and the recently emerged Middle-east respiratory coronavirus (MERS-CoV). Coronavirus also impact global economy by infecting farm animals like pigs (porcine epidemic diarrhea virus, PEDV), …
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Coronavirus Replication Inhibition by Herbal Extracts
Coronaviruses are plus-stranded RNA viruses that infect human and large variety of animals, including pig, cattle, dog, rat, rabbit, turkey, and bird. Human coronavirus has been known to cause common colds and perhaps gastroenteritis. Animal coronaviruses cause gastroenteritis, hepatitis, and a …
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Structural Basis of Bat and Raccoon Dog Angiotensin-Converting Enzyme 2 (ACE2) Receptor Recognition by Sarbecoviruses
… procyonoides) as a suspected intermediate host. Coronaviruses evolve to optimize receptor recognition in their natural hosts. A central question regarding the emergence of SARS-CoV-2 is why its receptor-binding domain (RBD) binds human angiotensin-converting enzyme 2 (ACE2) with high affinity …
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Conserved recombination patterns across coronavirus subgenera
… contributes to the genetic diversity found in coronaviruses and is known to be a prominent mechanism whereby they evolve. It is apparent, both from controlled experiments and in genome sequences sampled from nature, that patterns of recombination in coronaviruses are nonrandom and that this is …
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Investigating and Reprogramming RNA Folding with Molecular Probes
… long-range interactions in three additional coronaviruses, suggesting that this type of RNA structure is more common than previously thought. Overall, this thesis uses ASOs and mutational profiling to reprogram and investigate RNA folding. A wide variety of RNA sequences prove amenable to …
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… addressing current and future viral outbreaks. Coronaviruses, particularly SARS-CoV-2, continue to pose significant public health threats due to their zoonotic origin, adaptability, and rapid spread. While vaccines and virus-specific antivirals have been developed, emerging variants and novel …
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HOST RESPONSE TO PRIMARY AND SECONDARY CORONAVIRUS EXPOSURES AND POTENTIAL GERMINAL CENTER MECHANISMS ASSOCIATED WITH PROTECTION DURING RE-EXPOSURE
… disease. Additionally, seasonally circulating coronaviruses predate SARS-CoV-2. Therefore, it was hypothesized that factors such as host sex, age, and pre-existing immunity could influence SARS-CoV-2 infection outcomes. To address this hypothesis, I developed three objectives, leveraging the …
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