Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Coronary flow"”.
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Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model
… attacks result from reduced or blocked blood flow through major coronary arteries, resulting in permanent damage to heart muscle. Coronary blood flow (CBF) is thus important to measure in experimental animal models of heart disease. A standard method to measure CBF uses tracer microspheres (O …
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Coronary flow mechanics: an anatomically based mathematical model of coronary blood flow coupled to cardiac contraction
Coronary blood flow through the ventricular contraction cycle has been investigated in this thesis using an anatomically accurate computational model. Using Strahler ordered morphological data and an avoidance algorithm a three dimensional finite element model has been constructed of the largest …
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Exercise in Ponies: A Study of Myocardial Blood Flow, Coronary Vasodilator Reserve, Regional Distribution of Cardiac Output and Effects of Heart Rate on Coronary Flow
Transmural distribution of myocardial blood flow (MBF, 15 (mu)m diameter radionuclide labeled microspheres) was studied in 11 adult healthy ponies at rest {heart rate (HR) = 56 (+OR-) 4 beats.min('-1)}, during moderate (HR = 154 (+OR-) 3 beats.min('-1)) and severe (32 km.hr('-1), HR = 225 (+OR-) 7 …
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ΠΕΙΡΑΜΑΤΙΚΑΙ ΠΑΡΑΤΗΡΗΣΕΙΣ ΚΑΤΑ ΤΗΝ ΔΙΟΡΘΩΣΙΝ ΤΗΣ ΑΟΡΤΙΚΗΣ ΑΝΕΠΑΡΚΕΙΑΣ ΔΙΑ ΤΟΠΟΘΕΤΗΣΕΩΣ ΕΠΙ ΚΑΘΕΤΗΡΟΣ ΑΕΡΟΘΑΛΑΜΟΥ-ΒΑΛΒΙΔΟΣ ΕΙΣ 4 ΔΙΑΦΟΡΕΤΙΚΑΣ ΘΕΣΕΙΣ
… THE EFFECT OF A CATHETER MOUNTED VALVE ON THE CORONARY ARTERIAL CIRCULATION AND THE AORTIC PRESSURE DURING CORRECTION OF ACUTE EXPERIMENTAL AORTIC REGURGITATION. 1) THE CORRECTION OF AORTIC PRESSURE (DISTAL TO THE POSITION OF THE BALLOON VALVE) IN AORTIC REGURGITATION CAN BE ACHIEVED BY …
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Invasive Physiologic Assessment of Myocardial Viability After Primary Angioplasty in Acute Myocardial Infarction: Comparison With FDG-PET Imaging
BACKGROUND & PURPOSE: The state of coronary microcirculaton is an important determinant of myocardial viability and clinical outcomes in acute myocardial infarction(AMI). However, to date, there has been lacking in comparative studies on the most reliable invasive, on-site measurement for assessing …
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Correlation Between Serum Bilirubin Level and Coronary Microvascular Integrity in Diabetic Patients
… role in suppressing atherosclerosis and coronary artery disease. There has not been comparative studies for the relation of bilirubin level and coronary microvascular function in diabetes. This study investigates whether bilirubin can preserve coronary microvascular integrity in diabetes, …
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The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance
… have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contractility recovers function following …
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Arrhythmogenic potential of alpha-adrenoceptor stimulation in the rat heart
… occurred. Similarly no alteration in heart rate, coronary flow rate or myocardial high energy phosphate content accompanied the arrhythrnogenic effect of methoxamine. The QT interval increased with alpha₁-adrenoceptor stimulation, this being an indirect index of prolongation of the action …
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Multi-scale computational modeling of coronary blood flow: application to fractional flow reserve.
Introduction. Fractional flow reserve (FFR) is presently an invasive coronary clinical index. Non-invasive CT imaging combined with computational coronary flow modelling may reduce the patient’s burden of undergoing invasive testing. Research statement. The ability to obtain information of the …
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Papildomas adenozino vaidmuo mažinant infarkto dydį ir išsaugant kairiojo skilvelio funkciją pacientams, sergantiems ūminiu miokardo infarktu /
… conventional reperfusion therapy (percutaneous coronary intervention, i.e. PCI), role in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction. During the study we examined patients with the left ventricular anterior wall acute …
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Hämodynamische Charakterisierung eines murinen Sepsis-Modells
… during a septic shock. By using bradykinine the coronary flow decreased significantly in septic mice compared to the sham operated control group. This susceptibility to eNOS stimulation by bradykinine indicates a high level of eNOS activation secondary to sepsis. After the application of …
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Magnesium homeostasis in the mammalian heart
… of extracellular Mg2+ on contractility and coronary flow and the effects of hormonal and extracellular cationic control of Mg2+ homeostasis in the rat heart. Subsequently, the effects of dietary magnesium on the magnesium, calcium, sodium and potassium content of the heart (and other …
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Einfluss des HMG-CoA-Reduktase-Inhibitors Simvastatin auf Überleben und hämodynamische Parameter im murinen Sepsismodell
… in untreated septic mice. Consistently, the coronary flow reserve was exhausted in this group of animals. Treatment with simvastatin was followed by conservation of the coronary flow reserve indicating an eNOS-modulating effect of simvastatin. Besides modulating eNOS, iNOS modulation has been …
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Quantification of left-to-right shunt through Patent Ductus Arteriosus by colour Doppler
… study in lambs, indomethacin acutely reduced the coronary flow by up to 50% and the effect lasted for up to one hour. In our lamb model, we developed a non-invasive method to quantify the ductal shunt by ultrasound. The flow was measured with electromagnetic flow meters in the ascending aorta and …
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Microcirculatory and Myocardial Physiology in Ischaemic Left Ventricualr Dysfunction
… influences, and is affected by, changes in coronary flow. The integrity of the microvasculature is integral in myocardial perfusion and myocyte function, and remains incompletely understood in the context of impaired LV function. The main aim of this thesis was to examine the physiological …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
… have emerged regarding the safety of acute intracoronary (IC) MSC delivery specifically related to mortality, micro-infarction and microvascular flow restriction post cell therapy in animal models. This thesis aimed to firstly identify an optimal dose of MSC that could be tolerated when delivered …
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The Effects of Estrogen Receptor -Alpha, Estrogen and Phytoestrogen on Global Myocardial Ischemia -Reperfusion Injury
… bicarbonate buffer was perfused through the coronary arteries. All hearts were allowed to beat spontaneously. ERKOs started beating later and had a higher incidence of ventricular arrhythmias than the Controls. The OVX and the HPE+ICI groups had significantly lower left ventricular dP/dtmax. …
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Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… suppression of HRxLVDP and a 50% reduction of coronary flow, pre-exposure of hearts to 1 μM melatonin or 6-hydroxymelatonin eased the cardiac dysfunction. In addition, administration of melatonin or 6-hydroxymelatonin (2 mg/kg/d) significantly attenuated doxorubicin-induced cardiac dysfunction, …
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Insulin resistance and cardiovascular function - Observational, translational and interventional studies
… to suffer from this condition, leading to e.g. coronary ischemia as well as kidney dysfunction. Accumulating evidences indicate that the vascular pathological alterations may be a direct consequence of impaired glucose homeostasis and may occur long before diabetes is diagnosed. Early risk …
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Hypothermia as an adjunctive therapy in Acute Myocardial Infarction and Cardiogenic Shock
… myocardial infarction (STEMI) is to re-establish coronary flow in the epicardial arteries as soon as possible in order to reduce infarct size and associated complications. Hypothermia has in experimental studies been shown to reduce infarct size. Clinical trials, however, have not been able to …
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