Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Coregulators"”.
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
… across the genome, and the recruitment of major coregulators such as SRC3 and RIP140 by the ERs, and the association of ERs with other transcription factors and chromatin remodeling factors is incompletely understood. Therefore, in this report, we have used both chromatin immunoprecipitation …
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Cross-Modulatory Actions of Estrogen Receptor Beta on Estrogen Receptor Alpha Transcriptional Activity in Breast Cancer Cells
… the ability of ligand-ER complexes to recruit coregulators at ER binding sites of hormone-regulated genes.
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Integration of Nuclear- and Extranuclear-Initiated Estrogen Receptor Signaling in Breast Cancer Cells
… Receptors (ERs), which work in concert with coregulators and extranuclear signaling pathways to control gene expression in normal as well as cancerous states, including breast tumors. In this thesis, we have used multiple genome-wide analysis tools to elucidate various ways that are utilized …
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
… targeting nuclear hormone receptors and their coregulators (120 genes total), we screened the lung adenocarcinoma cell line NCI-H1819 for dependency on these genes during in vitro and in vivo growth. We identified six genes required for survival in vitro (BRCA1, CCND1, MED1, PHB, HNRNPU, and …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… to the PDK4 gene promoter. </p> <p>Transcription coregulators bind to nuclear receptors to facilitate or inhibit the transcription of the target genes. I have explored the role of several coregulators including the transcriptional coactivator peroxisome proliferator activated receptor gamma …
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The expression and regulation on antimicrobial peptide genes in insects: studies in the tobacco hornworm manduca sexta
… function in different insect species and unknown coregulators are responsible for the species-related activities. In chapter 4 the Manduca lysozyme protein was purified was purified and shown to prevent melanization by inhibiting the conversion of proPO to PO.
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I. A Structure-Based Approach Toward the Development of a Ligand-Receptor System With Unique Specificity. II. Synthesis and Evaluation of Hexahydrochrysene and Tetrahydrobenzofluorene Derivatives as Selective Estrogen Receptor Modulators
… and possibly due to different distribution of coregulators and target gene, as well as to a different tissue distribution of the two ER receptor subtypes (ERalpha and ERbeta). Ligands in the tetrahydrobenzo[a]fluorene and hexahydrochrysene series were synthesized and evaluated for their …
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Asssessing the Liquid-Liquid Phase Separation Abilities of Eyes Absent Protein
… activity through interactions with other coregulators, namely the SIX family of proteins. EYA proteins are comprised of two domains: a folded “EYA domain” (ED) in the C-terminus containing tyrosine phosphatase activity, and an intrinsically disordered “transactivation domain” (TAD) in the …
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Modulation of exercise-induced gene expression in human skeletal muscle by exercise intensity, training status and short-term endurance training
… protein kinases, transcription factors and their coregulators are recognised as regulators by which activation transduces physiological stimuli into transcriptional adaptations. This thesis examined the modulation of gene expression in human skeletal muscle under varying physiological conditions, …
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Regulation of SRC-3 localization and dynamics by phosphorylation during ERα-dependent transcriptional activation
… to the array of the receptor and associated coregulators, (ii) chromatin remodeling, and (iii) direct transcriptional readout of the reporter gene. Addition of E2 causes a visible opening (decondensation) of the PRL-array, colocalization of RNA Polymerase II, and transcriptional readout of …
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The Role of RUVBL1/RUVBL2 and Their Potential as Therapeutic Targets in Non-Small Cell Lung Cancer
… (RNAi) screen targeting nuclear receptors, their coregulators and chromatin remodelers. This screen identified RUVBL1 and RUVBL2 (collectively referred to as RUVBL1/2) as differentially required for the viability of NSCLC. We show that RUVBL1/2 require their ATPase activity to support NSCLC …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… I conclude that MRTFs function as essential coregulators of SRF to control actin dynamics during neuronal development via the Cdk5/Pctaire-1 kinase cascade. I also explore the role of MRTF-A and -B in cardiac development and function. Ablation of these MRTF genes in the embryonic heart …
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TMEFF2 is an epigenetic modulator that promotes androgen independent growth in castration-resistant prostate cancer cells
… the JMJD2 family of histone demethyalses, act as coregulators of AR, and many of these enzymes are implicated in CRPC. Because of this, HDMSs and HMTs have proven as attractive targets for therapeutic intervention. We have been studying TMEFF2, a protein that is regulated transcriptionally and …
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Breaking the MF curse: the regulatory role of the Methyl farnesoate – MEKRE93 pathway in crustacean molting
… transcriptional network that can be mediated by coregulators.
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Developmental Characterization of Cara Mitad: A Drosophila Nuclear Receptor Co-Regulator
… activities, we lack essential knowledge of the coregulators that are required for their proper function.</p><p>We have recently identified the Drosophila cara mitad (cmi) (`dear half') gene. The deduced CMI protein is closely related to the N-terminal half of the ALR-1/MLL-2 vertebrate NR …
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Identification of novel protein kinase regulators of TGFβ signalling
… regulating the activity of the transcriptional coregulators CREB-regulated transcriptional coactivators (CRTCs) and the class IIa histone deacetylases (HDACs) HDAC4 and HDAC5. From the research conducted during this thesis project, it is now evident that SIKs also function to modulate …
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Role of Src phosphorylation of FXR in bile acid regulation
… DNA binding, interaction with transcriptional coregulators and affecting the expression of FXR target genes in a gene selective manner. Mutation of a single amino acid, disrupting one of these post-translational modifications, has been shown to dramatically alter FXR function. Interestingly, …
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Mechanistic Studies Of A Novel Ppar-Gamma Mutant That Causes Lipodystrophy And Diabetes
<p>PPAR-gamma is a nuclear receptor that plays a central role in metabolic regulation by regulating extensive gene expression networks in adipose, liver, skeletal muscle and many other tissues. Human PPAR-gamma mutations are rare and cause a monogenetic form of severe type II diabetes with …
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Διερεύνηση μοριακών προγνωστικών παραγόντων στον καρκίνο του παχέος εντέρου
Ο καρκίνος του παχέος εντέρου αποτελεί ένα από τα συχνότερα κακοήθη νεοπλάσματα παγκοσμίως, προκαλώντας σημαντική νοσηρότητα και θνητότητα. Η συστηματική διερεύνηση της παθογένειας συντελεί σημαντικά στην πρόληψη, έγκαιρη διάγνωση, θεραπεία και πρόγνωση της νόσου. Στην εποχή της μοριακής ιατρικής, …
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Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… regulation requires the recruitment of coregulators to the regulatory regions of target genes. This recruitment is determined by the overall surface topography of the sNR. Phage display is a widely-used research technique for screening highly diverse peptide libraries to enrich for …