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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"Cord blood"”.
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Characterization of cord blood natural killer cells: implications for cord blood transplantation and insights into natural killer cell differentiation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Altered cord blood biomarkers in neonatal brain injury
… biochemical measurements. The umbilical cord blood (UCB) can give a snapshot of both the newborn and the in-utero environment. It is non-invasive to both mother and infant and contains microRNA (miRNA), messenger RNA (mRNA) and circulating proteins that can exist stably in the …
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Analysis of Maternal and Cord Blood for Antidiuretic Activity
… of antidiuretic and pressor substances in the blood is certain and he is firm in his convictions that the substance ie nothing but posterior pituitary hormone itself. | Hughes and associates (7) investigated this problem in 1953 and tabulated data on antidiuretic activity of plasma from normal …
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Cord Blood Collection in Pregnant Women for Stem Cell Research
Umbilical cord blood (UCB) stem cells form commonly banked types of human tissue. Confusion remains about sources of stem cells and their use. Birth is a once in a lifetime opportunity with 74 million births per year in the world and four million occur in the United States. Cord blood contains …
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Cell separation and cryopreservation of cord blood fractions for immunotherapeutic applications
… Nolan opened the UK’s first public umbilical cord blood (CB) bank (Anthony Nolan Cell Therapy Centre, ANCTC) in which CB is stored for haematopoietic stem cell (HSC) transplantation. Due to strict quality thresholds, the majority of units are not suitable for transplantation. Therefore, ANCTC …
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Pitfalls in Interpreting Umbilical Cord Blood Gases and Lactate at Birth
Acid-base status in umbilical cord blood is an objective measure of the fetus’ exposure to and ability to handle hypoxia. The objective of this thesis was to clarify some of the methodological pitfalls in interpreting umbilical cord blood gases and lactate values at birth. Study I pinpoints the …
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The effectiveness of PMTCT in the Free State - An anonymously linked cord blood survey
… the appropriate prophylaxis. [ Methods ] Cord blood specimens were collected anonymously from women delivering in 10 facilities in the Free State from November 2007 to April 2008. Collected specimens were tested for antibodies to HIV. Specimens found to be seropositive were tested for the …
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Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
… is to increase the number of immature umbilical cord blood stem cells (UCBSCs) for hematopoietic transplantation. Towards this goal, our lab adapted a culture technique to grow immature CD133+ UCBSCs (CD133+ cells). Although CD133+ cells proliferate rapidly in culture, a minority self-renew and …
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Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma
… and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and <em>ex vivo</em> expanded umbilical cord blood-derived NK (CB-NK) cells demonstrate activity comparable to that of peripheral blood-derived NK cells. However, large-scale expansion of …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
… to evaluate the genotoxicity and cytotoxicity of cord blood stem cell-derived (CBSC) exosomes on 6 samples of peripheral blood lymphocytes taken from healthy individuals and melanoma patients and on 3 samples of melanoma (CHL-1) cells. The limited number of samples was due to the time limitations …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
… to evaluate the genotoxicity and cytotoxicity of cord blood stem cell-derived (CBSC) exosomes on 6 samples of peripheral blood lymphocytes taken from healthy individuals and melanoma patients and on 3 samples of melanoma (CHL-1) cells. The limited number of samples was due to the time limitations …
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Genetic and environmental influences on cord blood atopic markers and on atopic sensitisation in infancy
… have shown that a raised concentration of cord blood serum immunoglobulin E (CBsIgE) is an excellent predictive marker for the subsequent development of atopic disease. Other potential predictive atopic markers such as cord blood eosinophils, platelets and anti-cow's milk serum IgG have …
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Salmon In Pregnancy Study (SIPS): the effects of increased oily fish intake during pregnancy on maternal and cord blood fatty acid composition, cord blood immunity and atopy outcomes in infants at 6 months of age
… n-3 PUFA intake, b) increase maternal and infant blood LC n-3 PUFA status, c) modulate fetal/neonatal immune responses and d) lower the risk of infant atopy determined at 6 months of age. The primary outcome measures of SIPS were the clinical signs of atopy in the offspring.<br/><br/>Pregnant …
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Determination of reference intervals and decision limits for thyroid stimulating hormone and thyroxine on cord blood samples
… hormone (TSH) and free thyroxine (FT4) in cord blood, as well as to compare the previous TSH radioimmunoassay with the current electrochemiluminescence immunoassay. Methods: Utilizing residual samples from the Peninsula Maternal and Neonatal Services (PMNS) CH Screening Program, this …
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Cord Blood-Derived Invariant Natural Killer T Cells as a Platform for Allogeneic Chimeric Antigen Receptor Cell Therapy
… our lab demonstrated iNKT cells derived from cord blood units (CB-iNKT) are enriched in naïve and central memory phenotype compared to iNKT cells derived from adult peripheral blood (AB-iNKT). Patients that receive CAR-T cells with higher proportions of naïve/central memory phenotype cells …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
Umbilical cord blood (UCB) is a well established alternative source of haematopoietic stem/progenitor cells (HSPC) for haematopoietic stem cell transplantation (HSCT). One factor limiting the wider use of UCB for transplantation is the relatively low cell dose from a UCB unit compared to bone …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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