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Showing 1 to 9 of 9 for “"Copper chelation"”.
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Describing the Cell Biology of Saprolegnia parasitica: Role of Metals and Respiration
… systems. Despite the increasing use of copper-based treatments to control this infection, little is known about how S. parasitica responds to fluctuations in metal availability at the physiological and mitochondrial levels. This study investigates the impact of copper and iron …
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Cellular Copper Import Mechanisms via Secreted Cuproproteins: Exploring Metal Homeostasis in Pseudogymnoascus destructans
… Bim1-like Proteins (BLPs) and high-affinity copper transporters (CTR proteins) transcription levels. These two families of copper-binding proteins have been shown to facilitate copper uptake, which is critical for fungal growth, survival, and virulence, especially in the nutrient-restrictive …
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Developing Analytical Tools to Study Copper Homeostasis in Biological Systems
Cellular copper concentrations are tightly regulated through a complex network of proteins and biomolecules that form thermodynamically stable yet kinetically labile complexes with Cu(I), the prevalent oxidation state of copper inside the reducing environment of cells. In order to shed new light on …
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Mechanisms of Copper Deficiency in the Zebrafish Embryo
… when faced with suboptimal nutrient levels. Copper is an essential nutrient required for critical biochemical processes. Severe defects in copper homeostasis lead to significant disease typified by the X-linked recessive disorder Menkes disease. Patients with Menkes disease have cutis laxa, …
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Complex formation equilibria of ligands with metal ions of biomedical interest
… give evidence of their possible implications in copper chelation. Moreover, the tyrosinase inhibitory properties of the kojic derivative[1] (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl3-({[(5-hydroxy-4-oxo-4H-pyran-2yl)methoxy]carbonyl} amino)propanoate and its complex formation equilibria with copper …
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The relationship between cupric ion activity and the toxicity of copper to phytoplankton
… between cupric ion activity and the toxicity of copper to phytoplankton and further to study the effect on copper toxicity of naturally occurring organic ligands. Culture experiments with an estuarine diatom Thalassiosira pseudonana (clone 3H) in highly chelated seawater media demonstrated that …
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Syntheses and characterization of copper(I) complexes for study of dynamic supramolecular ring-chain equilibria and application as photoredox catalysts
… these ligands and their complexes, especially copper(I) complexes, have been the subject of a multitude of studies in organic, inorganic and supramolecular chemistry. By using the chelation of copper(I) ion species to phenanthroline ligands and its derivatives, a metalated [2]pseudorotaxane, a …
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Leveraging copper chelators as targeted therapy for BRAFV600E mutant thyroid cancer
… time-course typical of PTC. MEK1/2 require copper (Cu) for kinase activity and can be inhibited with the well-tolerated and economical Cu chelator tetrathiomolybdate (TM). Cu chelators have been in use for decades in patients with Wilson’s Disease, a disease of Cu accumulation. Unlike …
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Polymer-Nanohydrogels sensor for the determination of H2S in polluted air by UaV drone [Sensore a base di nanohydrogel polimerici per la determinazione di H2S in aria inquinata tramite droni UAV]
L'inquinamento atmosferico è uno dei problemi ambientali più critici a causa dei suoi gravi impatti sulla salute umana e sulla stabilità ecologica. Questa tesi di dottorato introduce innovazioni nel monitoraggio degli inquinanti atmosferici antropogenici utilizzando nanomateriali integrati in …