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Showing 1 to 13 of 13 for “"Copper Transport"”.
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The role of copper in Parkinson's disease
Decreased copper levels has been consistently reported in the degenerating substantia nigra in Parkinson s disease, but the cause, and functional consequences, of this decrease are unknown. This thesis aimed to investigate neuronal copper levels and potential changes in copper transport in the …
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Structural and Functional Characterization of the Putative Pineal ATPase PINA
Copper plays a crucial role in human metabolism as a cofactor of enzymes responsible for respiration, iron metabolism, free radical disposal, and many other functions. Copper ATPases (Cu-ATPases) are a family of enzymes facilitating copper transport in the body. ATP7B is one of them, and it belongs …
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Mechanisms of Copper Deficiency in the Zebrafish Embryo
… when faced with suboptimal nutrient levels. Copper is an essential nutrient required for critical biochemical processes. Severe defects in copper homeostasis lead to significant disease typified by the X-linked recessive disorder Menkes disease. Patients with Menkes disease have cutis laxa, …
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Characterization of Metal Binding Peptides Derived from Copper Trafficking Proteins
<p>Copper was first released into the environment as the result of the mass generation of oxygen from photosynthetic bacteria roughly 2.7 billion years ago. While it proved to be poisonous to early life on Earth, those that met the evolutionary challenge utilized the metal as a cofactor in enzymes …
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Cellular Copper Import Mechanisms via Secreted Cuproproteins: Exploring Metal Homeostasis in Pseudogymnoascus destructans
… Bim1-like Proteins (BLPs) and high-affinity copper transporters (CTR proteins) transcription levels. These two families of copper-binding proteins have been shown to facilitate copper uptake, which is critical for fungal growth, survival, and virulence, especially in the nutrient-restrictive …
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Human ceruloplasmin gene and cDNA
… protein ismulti-functional. Functions include copper transport, serum and tissue anti-oxidant and anti-coagulation modulation. The cDNA of ceruloplasmin sharehomology with the cDNAs of factors V and VIII of the blood coagulation cascade,suggesting that the three genes evolved from a common …
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Acquired copper imbalance in diabetes-induced cardiac disease: Molecular mechanisms and reversibility
… chronic hyperglycaemia can disrupt myocardial copper balance and cause elevated serum copper levels, particularly in those patients with cardiovascular complications. It has also been shown that copper imbalance in the myocardium can be directly or indirectly involved in the pathogenesis of …
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Isolierung und Charakterisierung von Kupferhomeostase-Faktoren aus Trametes versicolor und deren Einfluss auf die Laccase-Expression
… Die zwei Kupferpermease-Gene cupA und cupB (copper uptake permease) konnten durch Komplementation der S. cerevisiae Deletionsmutanten ∆ctr1 bzw. ∆cup5 mit einer T. versicolor cDNA-Bank isoliert werden. Die aus den beiden Genen abgeleiteten Proteinsequenzen zeigen strukturelle Homologien zu …
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An integrated top-down and bottom-up proteomic platform to reveal potential salivary biomarkers of the rare disorders SAPHO syndrome, Wilson’s disease and Hereditary angioedema
… and the hepatic damage caused by the altered copper transport and its subsequent accumulation in the organism, which is at the origin of the pathology. The observed increase of the level of α-defensins 2 and 4 may give a contribution to the development of the disease by the improvement of the …
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The Binding of the Micronutrient Transition Metals to the Alkylation Products of Chemical Warfare Agent, Sulfur Mustard, and Thiols, Potentially Giving New Understanding to Physiological Effects of Exposure and Increased Toxicity
… forms complexes with key metal micronutrients: copper, nickel, cobalt, manganese, and zinc. Though the strength of binding to TTDPA varies, the complexes in many cases precipitate from solution. All metals produced a visible precipitate upon interaction with TTDPA under the conditions tested, …
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Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition
<p>Mechanisms of copper homeostasis are of great interest partly due to their connection to debilitating genetic and neurological disorders. The family of high-affinity copper transporters (Ctr) is responsible for extracellular copper acquisition and internalization in yeast, plants, and mammals, …
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Copper tolerance of Listeria monocytogenes strain DRDC8.
… strain DRDC8, the ctpA gene encodes a copper transporting P-type ATPase that apparently maintains intra-cellular copper ion homeostasis (Francis & Thomas, 1997a) and is also required for persistent infection of the liver and spleens of mice (Francis & Thomas, 1997b). However, the …
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Enhancing Cisplatin Delivery and Anti-tumor Efficacy Using Hyperthermia
… were investigated, along with the role of copper transport protein 1 (Ctr1) in this process. In addition, cisplatin was encapsulated within temperature-sensitive liposomes, which were used in combination with hyperthermia for targeted drug delivery. These studies demonstrated that the …