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Showing 1 to 11 of 11 for “"Copper Catalysis"”.
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NEW TRANSITION METAL CATALYSTS FOR CARBON-CARBON BOND FORMATION
… formation. First, the novel “sandwich” diimine copper complexes were successfully applied to the C-H insertion reaction of carbenes. This transformation facilitates the direct functionalization of alkanes without the need for an intermediate. This methodology holds the promise of more direct …
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Synthesis and evaluation of quadruple hydrogen-bonding modules for smart materials applications
… from bromonaphthyridines using copper catalysis with aqueous ammonia at ambient temperature and pressure is detailed in chapter two. Chapter three relates several general strategies for the preparation of functional DeUG derivatives. The chemistry described in the first two …
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INVESTIGATIONS IN IRON, COPPER, AND PALLADIUM –CATALYZED C-H BOND FUNCTIONALIZATION
… functionalization of C-H bonds via iron and copper catalysis have been developed. Additionally, functionalization of sp3 C-H bonds in amino acid derivatives using auxiliary-assisted palladium-catalyzed methodology is also demonstrated. A method for iron-catalyzed alkylation of arenes and …
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Development of Novel Methods for the Installation of Trifluoromethyl/Boryl and 1,2,4-Oxadiazole Moieties
… with inexpensive reagents NaSO2CF3 and TBHP with copper catalysis at room temperature. Under these conditions, a wide substrate scope afforded the (E)‐diastereomer exclusively in moderate to good yield. The reaction products' utility is demonstrated in synthesizing phenyl‐4H‐pyran, a potent and …
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Fused Heterocycles as Spinster Homolog 2 Inhibitors and Regio- and Stereoselective Copper-Catalyzed Borylation-Protodeboronation of 1,3-Diynes: Access to (Z)-1,3-Enynes
… One way to synthesize these compounds is through copper catalysis. Copper is favorable to other transition metals because it is an Earth-abundant, low-cost metal that can be utilized in regio- and stereoselective reactions. Conjugated 1,3-enynes are important functional groups that iii are found …
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Investigation of catalyst effects in enantioselective copper- and rhodium-mediated transformations of α-diazocarbonyl compounds
… compounds with particular emphasis on the use of copper-bis(oxazoline)-mediated enantioselective C–H insertion reactions leading to enantioenriched cyclopentanone derivatives. Through the use of additives, the enantioselectivity achieved with the copper catalysts for the first time reaches …
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Borylations and Silylations of Alkenyl and Alkynyl Carbonyl Compounds Employing a Mild and Environmentally Friendly Cu(II) Catalyst
An environmentally friendly, operationally simple copper-amine catalyst system is disclosed. Using this catalyst system, electron deficient alkenes and alkynes with diverse functional groups are borylated and silylated in high yields and with short reaction times. In the case of electron deficient …
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds
… acid and a carbon halide under palladium catalysis. Indeed, the Nobel Prize in Chemistry was awarded to Professor Akira Suzuki, along with Professors Richard Heck and Ei-ichi Negishi, in 2010 for their important contributions in palladium-catalyzed cross-coupling chemistry. Over the last …
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Applications of Hypervalent Iodine Reagents: From Enantioselective Copper-Catalysed Arylation-Semipinacol Cascade to Methionine Functionalisation for Peptide Macrocyclisation
… as arylation reagents for the enantioselective copper-catalysed arylative semipinacol rearrangement (SPR) of various tertiary allylic alcohols. This cascade reaction is a rare example of asymmetrically activating SPR using carbon electrophiles. Different substrate classes – including …
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Novel synthetic methodology employing transition metal catalysed reactions of α-diazo-β-keto sulfonamides and α-cyano-α-diazoacetates; the impact of substituents on the reaction pathway
… employing rhodium and copper catalysts. While the α-diazo-β-keto sulfonamides were specifically designed to investigate rhodium- and copper-catalysed intramolecular C–H insertion, the α-cyano-α-diazoacetates and α-arylsulfonyl-α-diazoacetates probed intramolecular …
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Development of three-component alkene and 1,3-diene carbofunctionalization reactions
Given the prevalence of nitrogen-containing molecules in pharmaceuticals and agrochemicals, the development of efficient amination reactions is an essential research effort within the broad confines of organic method development. The ever-increasing complexity of the molecular structures used to …