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Showing 1 to 20 of 134 for “"Cooperativity"”.
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Quantifying Cooperativity in Non-Covalent Networks
… supramolecular chemistry. Some quantification of cooperativity in networks of non-covalent interactions has been done in the literature, but these experiments are often complex and not easily applicable to many different types of functional group. The work in this thesis builds on previous work in …
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Cooperativity: Physiologic Cornerstone and Emerging Therapeutic Design Principle
The content of this work is based on the previously published articles that are cited below.
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P22 arc--energetics and cooperativity of DNA binding
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Allostery and GroEL: Exploring the Tenets of Nested Cooperativity
… cycle and offers a refined model for nested cooperativity that successfully accounts for the effects of these ligands. Initial studies take advantage of a single ring variant, termed SR1, to examine the allosteric properties of GroEL in the absence of complicating interactions arising from …
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Artificial Transmembrane Signalling and Cooperativity in H-Bonded Networks
… transmembrane signalling, and a second on cooperativity in hydrogen bonded networks. Cells rely on complex signal cascades where proteins are responsible for the transmission and amplification of chemical signals across membranes. While numerous examples of biomimetic synthetic transport …
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Global deconvolution of heterotropic cooperativity in cytochrome P450 3A4
… kinetics, called “homotropic” and “heterotropic” cooperativity respectively. Significant progress has been made towards understanding the enzyme’s complex kinetics by work in our laboratory to isolate the enzyme in Nanodiscs. This provides a homogenous, monodisperse, native-like environment, where …
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Regulation of neuronal genomic integrity through histone deacetylase cooperativity
While the mechanisms preserving genomic integrity are well defined in proliferating cells, corresponding pathways in postmitotic neurons remain poorly understood. In this report, I characterize the functions of two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand …
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Cooperativity and communication in archaeal Cdc48·20S, an ancient proteolytic machine
ATP dependent proteolysis is a process essential for life and is carried out by AAA+ proteases. AAA+ unfoldases use the energy of ATP hydrolysis to power the unfolding and translocation of protein substrates into compartmentalized peptidases for regulated proteolysis. Cdc48 is a highly conserved …
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Metal-ligand cooperativity in first row transition metals: hydrosilylation catalysis and mechanistic insights
The utility of transition metal catalysts has greatly expanded the scope of organic reactions. Historically, homogenous catalysis is dominated by platinum group metals (PGMs) due to their relative high activity and stability to air when compared to the 1st row counterparts of PGMs. However, 1st row …
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Cooperativity of ligand binding as a function of monomer-dimer equilibrium Parameters and Acceptor Concentration
… involving ligand interactions is presented. Cooperativity features of specific limited models are analyzed by selecting the appropriate family of equilibrium constants from this general scheme. Each system is then characterized in terms of Hill coefficient dependency on alterations in values …
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Investigation of Waterborne Epoxies for E-Glass Composites
… results in an increased level of viscoelastic cooperativity. Current research has determined that the cooperativity of an epoxy/E-glass composite is also sensitive to the surface chemistry of the glass fibers. Model single-ply epoxy/E-glass laminates were constructed in which the glass was …
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A study of conformational response of DNA to nanoconfinement by Monte Carlo simulation
… chain in a nanochannel was explored by using the cooperativity model. The two-parameter cooperativity model was applied to describe the hairpin formations in term of S-loop formations and its growth along the chain. The cooperativity model was then compared with Monte Carlo simulation in order to …
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Antimicrobial Peptides Activity and Efficacy Prediction by Stochastic Models and Machine Learning Methods
… levels. We also investigated the effect of AMP cooperativity on efficacy as measured by minimal inhibitory concentrations (MIC), fractional inhibitory concentrations (FIC), and our acceleration parameter R by looking at cases with 1, 2, 3, and eventually an arbitrary number m types of AMPs. Our …
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Allosteric Interactions in Coordination Cages
… bind fullerenes with all-or-nothing positive cooperativity and assemble supramolecular entities internally; a heteroleptic triangular prism capable of recognising steroids and enantiopure natural products; and a tetrahedron that binds fullerene clusters. Each of these architectures employs one …
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Computational Studies on R67 Dihydrofolate Reductase: An Investigation Into Its Unique Binding Patterns
… productive complex, this enzyme exhibits binding cooperativity. Unlike other allosteric enzymes which achieve binding cooperativity through conformational changes, this enzyme does not appear to undergo any backbone alterations upon ligand binding. Therefore, a different mechanism must be involved …
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Agonist-Induced Conformational Changes In The Nmda Receptor
… understood, including the phenomenon of negative cooperativity between the glycine- and glutamate-binding sites of the receptor and the mechanism controlling partial agonism. Past studies utilizing static structural snapshots of the receptor or isolated domains of the receptor have provided …
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A STUDY OF THE THERMODYNAMICS OF ANION BINDING TO HUMAN SERUM TRANSFERRIN
… is shown to occur pairwise with high positive cooperativity, an observation unique to nonstereospecific anion-protein interactions. It is shown that human serum transferrin has binding sites for four nonsynergistic anions, two in each domain. The association constants are reported.</p><p>It is …
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Cooperative assembly confers regulatory specificity and promotes evolution
… to elucidate the direct contribution of TR cooperativity to establishing new regulatory connections across evolutionary time. With design guided by a predictive theory of gene network evolution, cooperative circuits are poised for CRM evolution in longterm culture experiments at accelerated …
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Studies of the NAD metabolism of Haemophilus influenzae
… functioned in a manner indicative of negative cooperativity with all substrates except several modified in the adenine ring. The most effective inducer of negative cooperativity was NAD as indicated by its Hill coefficient of 0.26. The enzyme was inhibited by adenine nucleotides _ and 5'-AMP, …
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