Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Cooperative regulation"”.
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A maternal low-protein diet during gestation induces hepatic autophagy gene expression only in the female offspring Sprague-Dawley rats
… liver of female offspring through differential cooperative regulation. Overall, our data demonstrated that hepatic autophagy gene expression could be induced by a maternal LP diet only in the female rat offspring. This transcriptional program involves in activated p- eIF2α/ATF4 pathway and …
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Cooperative assembly confers regulatory specificity and promotes evolution
Cooperative self-assembly between transcriptional regulators (TRs) and DNA cis-regulatory motifs (CRMs) coordinates precise gene expression in eukaryotes. Complexes of multivalent TRs enable the formation of highly specific regulatory connections between otherwise weakly-interacting, …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
… in part by extensive alternative splicing (AS) regulation. RBPMS, a master splicing regulator in differentiated VSMCs, is responsible for approximately 20% of AS changes observed during dedifferentiation in PAC1 VSMCs (Nakagaki-Silva et al., 2019). However, the cooperative and antagonistic …
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Defining Determinants of Primary Drug Resistance in Precision Cancer Therapies
… therapeutic approach that functions through the cooperative regulation of translation-coupled oncoprotein stability and holds promising translational potential for the treatment of this difficult-to-treat disease subtype. In the second context, despite extensive molecular characterization of …
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… in this SC injury response and gain insight on cooperative regulation of this process by transcription factors and miRNAs. Together, the results described in the present thesis represent a significant increase in our understanding of how mitochondrial abnormalities specifically in SCs contribute …