Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 254 for “"Controlled release"”.
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Controlled release microchip
Microchips for constant release are not a new concept, but a controlled release chip, which does pulsatile release at variable time intervals, is clearly more efficient and useful. The process was completely understood about the theory of operation, the manufacturing procedure and the robustness of …
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Controlled release in inhalation
… study the viability of spray drying to introduce controlled release vectors into dry powders for inhalation was investigated. The first experimental section highlights the use of leucine in producing highly respirable spray dried powders, with in vitro respirable fractions (Fine particle fraction, …
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A controlled release microchip
… There exist numerous cases where constant release is not the optimal method of drug delivery; instead, delivery of pulses of drug at variable time intervals is the preferred method. This method is commonly referred to as pulsatile delivery, and it is preferred in some cases because it …
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Development of an Intraruminal Controlled-Release Device
Slow-release devices retained in the rumen, are a simple method for continuous administration of bioactives to ruminant animals. To satisfy regulatory requirements and avoid waste of bioactive due to under- or over-dosing, it is advantageous to have a constant and predictable release rate. Existing …
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Investigating Controlled Release Pulmonary Drug Delivery Systems
… robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved by reducing the number of times drugs need to be administered. In this study, two controlled pulmonary drug …
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Controlled release of drugs from surgical suture
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1987.
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CHITOSAN PARTICLES FOR THE CONTROLLED RELEASE OF PROTEINS
… nanoparticles? 3) How to overcome the burst release of chitosan nanoparticles? 4) How to overcome the aggregation disadvantage in the contritional preparation process of TPP-gelated chitosan microparticles? 5) How to construct a composite particles system to realize the sustainable release of …
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Controlled release of Isothiazoline biocides from industrial minerals
… can be used to adsorb isothiazoline biocides for controlled-release and antimicrobial purposes. The absorption of the biocides on the mineral powders was achieved by way of using a bench high shear mill (dry process), or combining them to hydrated minerals (wet process). The characterisation of …
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Characterization of Biodegradable Polymeric Microparticles for Controlled Release
… arena will help achieve better control of release and allow for application of more potent therapeutics.
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Engineering chemoattractant gradients using controlled release polysaccharide microspheres
… microspheres releasing chemoattractant in a controlled manner. These alginate hydrogel microspheres, ~30 [mu]m in size, were crosslinked with Ca2+ between gluronic acid units on alginate backbones and provided a natural and bioactive environment for chemokines. The chemokines could be loaded …
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Functional particles for controlled release and cell surface engineering
… a stimuli-responsive particle with an enhanced release profile as a new formulation pathway to assemble the hemostatic fibrin-based matrix. Chapter 3 presents a polymersome-based cell adherent nanostimulator for enhanced stem cell paracrine factor secretion. I further demonstrated applications …
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Novel Carbopol-Wax Blends for Controlled Release Oral Dosage Forms
… can be used in low concentration in developing controlled release formulations. This increases the cost effectiveness and number of formulation options. In spite of its effectiveness, carbopol is one of the most efficient however underutilized polymer in oral controlled drug delivery system …
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Development and Characterization of Controlled-Release Permanganate Gelfor Groundwater Remediation
… solution mixed with a gelling agent. The controlled-release permanganate gel (CRP-G) solution was developed so that it may be injected and flow with groundwater and subsequently increase in viscosity over time to remain emplaced and slowly release MnO<sub>4</sub><sup>- </sup> in a …
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Controlled Release System for Localized and Sustained Drug Delivery Applications
Current controlled release formulations has many drawbacks such as excess of initial burst release, low drug efficiency, non-degradability of the system and low reproducibility. The present project aims to offer an alternative by developing a technique to prepare uniform, biodegradable particles …
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A resorbable polymeric microreservoir device for controlled release drug delivery
… of a degradable polymer. Control over the release of drugs from the device was achieved by changing the molecular weight of the reservoir membranes. The current prototypes have 36 reservoirs, but the size and geometry of the polymeric chip could be designed to optimize device performance …
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Poly(ethylene glycol) hydrogel microspheres as a controlled release device
… the diffusion of the chemoattractant could be controlled by varying the amount of crosslinker and by incorporating ionic groups in the polymer matrix. It was found that the crosslinker amounts successfully altered the release profiles of the protein. The ionic groups incorporated in the polymer …
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Development of Carbon-Based, Controlled-Release Soil Ameliorants Through Chemical Pathways
… waste agricultural residues into carbon-based controlled-release fertilizers (CBCRFs) through chemical carbonization followed by nutrient impregnation. The process involved treating lignocellulosic biomass with 93% sulfuric acid to produce a stable carbon matrix, subsequently neutralized with …
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Novel Plasmonic Nanostructures for Applications in Sensing, Imaging, and Controlled Release
… of Au nanocages as a new platform for controlled drug release. Two temperature-regulated systems were developed by combining Au nanocages with high-intensity focused ultrasound: HIFU). Because it can penetrate more deeply into soft tissues than near-infrared light, HIFU is a potentially …
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A Novel Squid Glaucoma microShunt for Controlled Release of Aqueous Humor
… requiring extensive surgical dissection, 2) uncontrolled aqueous humor (AH) release risking vision loss, and 3) prolonged inflammation and fibrosis leading to a complication rate over 50% at 5 years. To address this clinical need, we developed a novel GDD, the Squid Glaucoma microShunt (SGS) …
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