Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Controlled drug release"”.
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Controlled drug release from oriented biodegradable polymers
… orientation as a novel method for controlling drug release from biodegradable polymers. The effect of various degrees of polymer orientation was studied in oriented Poly (L-lactic acid) (PLA) films containing curcumin and theophylline as model drugs. Additionally, direction specific drug …
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Remote controlled drug release in drug-eluting stents
… the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This …
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Stimuli-Responsive Polymer Systems that Respond to Redox Potential and pH for Controlled Drug Release
Nanocarriers are widely investigated drug delivery systems that can overcome physiological barriers by tuning nanocarrier size, shape, surface chemistry, targeting ligand conjugation, and material composition. Furthermore, they have stimuli-responsive moieties that translate physiological signals, …
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Advancing prostate cancer therapy: synthesis and characterization of docetaxel-loaded magnetic iron oxide nanoparticles for controlled drug release.
… common cancers among men worldwide, and current drug administration methods of front-line drugs like Docetaxel (DXL) face challenges, including non-specific treatment causing several side effects and the development of drug resistance, which affects patients' response and quality of life during …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low gelation …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low gelation …
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Development of Soft-Matter Delivery Systems: Coupling pH Responsive Polymers to Porous Silica Particles
… silica nanoparticles for potential use in controlled drug release and therapeutics. As demonstrated here, lipid bilayer coatings can be easily replaced with different polymer analogs allowing for dynamic response to environmental stimuli. In addition to coupling commercially available …
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Design, Synthesis and Characterization of Porous Silica Nanoparticles and Application in Intracellular Drug Delivery
Nanoparticle mediated drug delivery approaches provide potential opportunities for targeting and killing of intracellular bacteria. Among them, the porous silica nanoparticles deserve special attention due to their multifunctional properties such as high drug loading, controlled drug release and …
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Bioengineering functional polymer systems for glycan-based targeting and drug release
Bioengineering drug delivery facilitates re-potentiation of existing drugs and drug candidates, bypassing hurdles in novel drug development and accelerating the advance of medicine. Drug delivery strategies aim to enhance therapeutic effect by enhancing delivery to the target cells or tissues, …
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Polymer based microscale and nanoscale technologies for optical and biomedical application
… due to patterning. We also investigate the drug coating process in this film for its use in controlled drug release platform.</p> <p>Finally, I used the drug coated and nano-patterned PLLA film for its potential application in biodegradable coronary stents. We fabricated the stents by …
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INJECTABLE HYBRID HYDROGELS FOR LOCAL CHEMOTHERAPY OR TUMOR-SPECIFIC RESECTION
… invasive surgery and for cancer treatment. The controlled drug release and the targeted delivery are essential parameters that need to be controlled in order to have active compound in a tumoral environment released at a certain dose over the time.
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
Polymeric ‘smart drug delivery systems’ respond to external and environmental stimuli to modulate drug release at the right time and in the right place. Here I present several polymer systems to overcome challenges in spatiotemporal control of drug delivery. First, a novel acid-labile liquid …
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Molecular-thermodynamic theories of micellization of multicomponent surfactant mixtures and of pH-sensitive surfactants
… be utilized to control self-assembly, including controlled drug release, targeted gene delivery, and the fabrication of nanoscale materials for optics, electronics, and sensors. First, a molecular-thermodynamic (MT) theory was developed to account for counterion binding to mixed micelles composed …
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Design and Synthesis of Doxorubicin Conjugated Gold Nanoparticles as Anticancer Drug Delivery System
… effects, a gold nanoparticles-based anticancer drug delivery system was designed. Five novel thiolated doxorubicin analogs were designed and synthesized and their biological activities have been evaluated. These doxorubicin analogs and the poly(ethylene glycol) (PEG) stabilizing ligands were …
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A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery
… been the polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic degradation pattern whereby the final …
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DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… systems are often limited by their inadequate drug loading and release properties. This study reports the integration of oil into PLGA to form the prototype of a hybrid drug carrier PONC. Our primary goal is to confer the key strength of lipid-based drug carriers, i.e. efficient encapsulation …
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Construction of nano-assembled microcapsules embedded with gold nanoparticles for use in novel drug delivery systems
… these issues has led to the development of DESs (Drug eluting stents). However long term effectiveness of DESs and various drug delivery systems have raised concerns. Also current DESs does not have the capability to adjust the drug dose or release kinetics that corresponds to the diseased status …
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Microstructured materials synthesis via salt-assisted ultrasonic spray pyrolysis
… superhydrophobic surfaces, energy storage, and controlled drug release and hyperthermia. First, salt-assisted USP is used to make roughened ZnO microspheres. By controlling the amount of NaCl in the precursor solution, the agglomerated ZnO nanoparticles will form microspheres with varying …
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Development of Multifunctional Drug Delivery Systems for Locoregional Therapy
… systemic adverse effects. In this approach, drug is administered through topical instillation, inhalation, intra-lesional or intra-arterial injection. Decades of experience in locoregional treatment have delivered meaningful benefits to patients with localized diseases (e.g., osteoarthritis, …
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