Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Control neuronal"”.
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Rutas de señalización intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata
… signals and molecular mechanisms that control neuronal apoptosis. We have mainly focused our attention to the survival pathways Duch as RAS/RAF/MAP-kinases, PI3-K/PKB, as well as death pathways, stress-activated MAP-kinases (JUN-kinases and p38).
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Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System
… (para), a voltage-gated sodium channel, shown to control neuronal excitability; and (ii) tramtrack69 (ttk69), a transcription factor known to regulate glial cell number and fate determination during embryonic development. In the absence of miR-184, homozygous loss-of-function mutant adult flies …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… contexts, particularly during cardiovascular and neuronal development. This dissertation aims at studying the in vivo relevance of the partnership between Serum response Factor (SRF) and its Myocardin Related Transcription Factor (MRTF) coactivators during development. I present here my studies on …
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The investigation of pathophysiological mechanisms underlying KV7-related epilepsy and neurodevelopmental delay
… neurological disorder (Epilepsy Foundation). Neuronal Kv7 channels composed of Kv7.2/KCNQ2 and Kv7.3/KCNQ3 subunits are enriched at the axonal plasma membrane where their voltage-dependent potassium currents suppress neuronal excitability. Close to 400 variants in Kv7.2 subunit cause Benign …
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Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
Neuronal maturation is an intricate and tightly-controlled process in neurodevelopment, during which neuronal cells acquire their mature molecular, morphological and electrophysiological properties to function as the central components of the nervous system. However, the cell-intrinsic mechanisms …
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Interfacing insect neuronal networks with microelectronic devices
… work deals with the challenge of designing neuronal networks in vitro in order to mimic these sensory systems. The cercal sensory system of crickets is one of the most sensitive sensory systems known. Neurons from the terminal abdominal ganglion (TAG) are responsible for the first …
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
… that microglial phagocytosis and inflammation control neuronal function and survival. Some microglial activity may be beneficial during neurodegeneration, but excessive release of pro-inflammatory cytokines and reactive oxygen/nitrogen species is a hallmark of neurodegenerative disease and can …
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Feedback control of complex oscillatory systems
… paper an approach which ensures an efficient control of such diverse systems as noisy or chaotic oscillators and neural ensembles is developed. This approach is implemented by a simple linear feedback loop. The dissertation paper consists of two main parts. One part of the work is dedicated to …