Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 202 for “"Contrast agents"”.
-
Fluorinated Metal Complexes as MRI Contrast Agents
… and provides 3-D imaging directly in vivo. Contrast agents are used in order to enhance the resolution of the images from MRI. All currently used contrast agents are based on gadolinium and image water protons in the human body. However, gadolinium-based contrast agents are principally …
-
Superparamagnetic contrast agents for magnetic resonance imaging
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1994.
-
Lanthanide Functionalised gold nanoparticles as MRI contrast agents
… and characterise nanoparticle-based MRI contrast agents. In the first instance, the DTPA (diethylenetriaminepentaacetic acid) based ligand was designed, synthesized and characterised. This ligand was utilised for stabilisation of gold nanoparticles. The gold nanoparticles protected by …
-
Magnetic resonance characterization of gadolinium-based contrast agents
… been used for characterizing gadolinium-based contrast agents in NMR Imaging in this thesis. Many Gd-based contrast agents were studied including Gd DTPA(dimethylenetriaminepentaacetic acid). The zero field splitting energies and g values of Gd complexes were obtained in frozen solutions by the …
-
Magnetic resonance imaging contrast agents for chemical sensing
… used for examining the human body. MRI contrast agents currently used in the clinic assist physicians in locating problematic areas, but other tools are needed to interrogate the chemical environment of these areas once found. The fast clearance rate of contrast agents, in particular, …
-
Target-specific contrast agents for magnetic resonance microscopy
… features in the human brain, but increased contrast is required to visualize more subtle distinctions. The goal of this thesis is to employ target-specific MR contrast agents to regionally alter relaxation rates, resulting in increased contrast in ex vivo MRM of the human brain, with the aim …
-
Optical Imaging Of Tissue Physiology With Exogenous Contrast Agents
… one can learn from optically emitting exogenous contrast agents in living tissue. The first set of experiments concurrently measured cerebral blood flow and bothintravascular- and extravascular-tissue oxygen concentration in a rat brain during functional activation; the new instrumentation needed …
-
Acoustic characterisation of ultrasound contrast agents at high frequency
… the acoustic properties of ultrasound contrast agents (UCAs) at high ultrasound frequencies. In recent years, there has been increasing development in the use of high frequency ultrasound in the fields of preclinical, intravascular, ophthalmology and superficial tissue imaging. Although …
-
The Role of Ultrasound Contrast Agents in Producing Sonoporation
This dissertation successfully elucidated the physical mechanism of sonoporation. Oscillation of UCAs near a cell produced microstreaming that resulted in shear stress on the cell membranes. This shear stress resulted in sonoporation, a permeability change that allowed for the uptake of …
-
Electronic Relaxation Properties of Gadolinium Based MRI Contrast Agents
Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
-
Quantification of Ultrasound Contrast Agents Using High-Frequency Ultrasound
Ultrasound contrast agents (UCAs) are small microbubbles filled with gas. Because of their scattering properties, UCAs enhance the diagnostic capabilities of ultrasonic imaging. UCAs are associated with therapeutic or enhancing therapeutic applications of ultrasound and with possible adverse …
-
Rotational Dynamics and Proton Relaxation of MRI Paramagnetic Contrast Agents
… the relaxation characteristics of paramagnetic contrast agents (PCA's) used in magnetic resonance imaging. In this work, a methodology employing continuous wave electron paramagnetic resonance spectroscopy has been developed and established to probe the rotational dynamics of model contrast …
-
Design and Development of Calcium Sensitive Contrast Agents for fMRI
… to combine MRI with calcium-sensitive contrast agents because of the important role of calcium as a second messenger in cellular signaling pathways. Here we describe a family of calcium sensors for MRI based on the conjugation of superparamagnetic iron oxide nanoparticles (SPIOS) to …
-
Engineering genetically-encodable MRI contrast agents for in vivo imaging
… way to overcome this limitation is to develop contrast agents that report physiological events at a molecular level. Traditionally MRI contrast agents have been based on small molecules that chelate paramagnetic ions such as Gd (III), but synthesis and delivery of such exogenously applied …
-
Gadolinium Endohedral Metallofullerenes for Future Magnetic Resonance Imaging Contrast Agents
… next generation magnetic resonance imaging (MRI) contrast agents due to their significantly improved efficiency and safety, as well as multi-day body retention which allows for a longer surgery and observation compared to current contrast agents. In Chapter 1, I have reviewed the development of …
-
Nitroxide Spin Labels as NMR Contrast Agents: Delivery, Metabolism and Relaxation
In this project, the potential of nitroxides as contrast agents for magnetic resonance imaging (MRI) has been studied. The difficulties involved in using nitroxides as in vivo MRI contrast agents, such as premature metabolic convertion of nitroxides to their nonparamagnetic state, lack of tissue …
-
The design, syntheses, and physico-chemical studies of MRI contrast agents
… clinical diagnostic tool. The development of MRI contrast agents allows for even greater diagnostic ability. This thesis will address the design, syntheses and physico-chemical studies of two specific classes of MRI contrast agents: the DTPA bisamide macrocycles and the bile salt-like …
Page 1 of 11