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Showing 1 to 10 of 10 for “"Continuous crystallization"”.
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Control of polymorphism in continuous crystallization
Continuous manufacturing has gained significant interest in recent years as the ultra-lean mode of pharmaceutical production. Albeit the increasing number of studies on the process dynamics in continuous crystallization, in particular in yield improvement and impurity separation, the research …
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Microfluidic systems for continuous crystallization of small organic molecules
… presents one of the first demonstrations of continuous crystallization in microfluidic devices, and illustrates their use for various applications related to crystallization of small organic molecules. Crystallization is an important process in a number of industries, including specialty …
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Novel continuous crystallization configurations for improved yield, purity and controlled crystal size distribution
Continuous crystallization process has potential advantages such as lower cost and improved flexibility in pharmaceutical production when compared to batch crystallization. A good continuous crystallization process should achieve a high product yield and purity comparable to current batch …
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Chiral resolution control in batch and continuous crystallization processes for a conglomerate forming compound
… in the pharmaceutical industry is preferential crystallization. In a preferential crystallization process, supersaturated racemic (equal mixture of both enantiomers) solution is seeded with pure crystals of the preferred enantiomer. Over time these crystals grow, removing the preferred …
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Mathematical modeling and design of novel semi-continuous and continuous crystallizations
Crystallization is an important separation technology used for the purification of products during their final stages of manufacturing. Novel semi-continuous and continuous crystallization process designs are receiving increasing attention in pharmaceutical industry due to significant advantages in …
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Optimal Control of Antisolvent and Cooling Crystallization
Common quality requirements for crystallization products is so critical in the pharmaceutical industry, including the demands of the drug administration and customers (e.g. bioavailability, size uniformity, and polymorphic form) and the concern of the manufacturer for downstream processes such as …
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Fast stochastic model predictive control under parametric uncertainties
… of MPC to control a highly integrated nonlinear continuous crystallization process
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Crystallization process development and spherical agglomerates for pharmaceutical processing applications
The control of crystallization steps is essential in the production of many materials in the pharmaceutical, materials, and chemical industries. Additionally, due to increasing costs of research and development, reductions in manufacturing costs by moving from batch to continuous manufacturing are …
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Multidimensional population balance modeling and optimization of continuous reactive crystallization
… ratio. The applicability of the 2D PBM for continuous crystallization is made possible by introducing growth rate dispersion mechanism that accounts for the broadening of the size distribution from the measured 2D CSD. Computationally efficient and highly resolved numerical methods are …
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DEVELOPMENT OF NOVEL DESIGN AND CONTROL APPROACHES FOR INTEGRATED CRYSTALLIZATION OPERATION AND SYSTEMS
Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to …