Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Content uniformity"”.
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Improvement of Release Criteria for Immediate Release Solid Oral Dosage Forms
… dubious origin would receive. Reliable tests for content uniformity and dissolution are required to protect the safety of the supply chain. A study was designed to test the hypothesis that existing compendial tests for content uniformity and dissolution would protect the supply chain against …
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Preparation and characterization of fast dissolving pullulan films containing griseofulvin nanoparticles for bioavailability enhancement
… gum loadings, and drug particle size on the drug content uniformity, mechanical properties, and in vitro drug release from the films. Results show that thin strip films exhibited excellent content uniformity, fast drug release without having excessive amount of toxic surfactants, and easy …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
… processing which result in with improved drug content with comparable sustained release profile to the marketed formulation. The key objectives of this dissertation chapters are: (1) to introduce HME as an efficient technique alongside when combined with other novel techniques in pharmaceutical …
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Performance-Based Quality Specifications: The Link between Product Development and Clinical Outcomes
… analyses revealed that patient compliance and content uniformity significantly influenced the probability of observing an adverse event.</p><p> The Monte Carlo risk assessment platform defined the link between the critical quality attributes (CQAs) and clinical performance (i.e., …
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… absorption profile, flowability, stability, content uniformity, dissolution and tabletability. Tabletabilty data demonstrated an immerse enhancement in the drug’s tensile strength upon processing using different blending energy (~8 folds) and preparation techniques (~11 folds), various …
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… distinct limitations, to characterize the drug content uniformity and distribution of hot-melt extruded paracetamol (PMOL) tablets. PMOL tablets were obtained using HME extrudates by applying ‘hot’ and ‘pre-mix’ approaches to PMOL/888 ATO at different processing temperatures and different …
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Electrostatic powder deposition as a dry powder process to prepare orodispersible films
… mixture exhibited significantly higher drug content variability. The active films exhibited favorable mechanical properties due to the plasticizing effect of APAP on PEO. Additionally, the films exhibited rapid drug release in vitro, with greater than 85% drug release by two minutes. Films …
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Process analytical technology in tablet manufacturing
… required to improve shapes on granules.Blending uniformity was firstly studied by ATR-IR spectroscopy and PCA showed similarity of data after 10 min of blending in all 3 batches. Therefore, DoE was employed to optimize three critical process parameters; solid feeding rate, liquid feeding rate and …
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Design and development of polymeric nanoparticles by continuous manufacture using twin screw extrusion
… in increased nanoparticle recovery and improved content uniformity.<br/><br/>We have shown that extrusion can be used to make reproducible nanoparticles in a continuous fashion. Furthermore, we have shown from preliminary in vitro data that the nanoparticles can allow for controlled or targeted …
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Electrodeless electro hydrodynamic printing of personalized drug dosages
… met the reproducibility requirement critical for content uniformity and that the porous film rapidly disintegrated resulting in instant release of drug which could be useful in fast orally dissolvable medicinal film dosage forms.
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Formulation and dissolution of polymer strip films for the delivery of poorly water-soluble drug nanoparticles
… All films up to 50 wt% drug loading show good content uniformity and drug nanoparticle redispersibility, suggesting that high drug loading can indeed be achieved in polymer films, although films tend to become less elastic and more brittle as drug loading increases above 40 wt%. Finally, a …
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USE OF HYPROMELLOSE AND HYDROXYPROPYL CELLULOSE TO DEVELOP AN AGE APPROPRIATE PLATFORM TECHNOLOGY FOR THE ADMINISTRATION OF MEDICINES TO CHILDREN
… used to form films which meet the pharmacopoeial content uniformity criteria typically applied to oral dosage forms. HPC films have application for administering drugs to paediatric or geriatric patients by disintegrating in the mouth and so overcoming swallowing difficulties; potentially …