Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Congenital malformations"”.
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Uniparental disomy as a cause for congenital malformations and or developmental delay in inherited apparently balanced chromosomal rearrangements
… However the frequency of mental retardation and congenital anomalies appears to be increased among individuals who carry a de novo or an inherited apparently balanced chromosomal rearrangement [Funderburk et. al. 1977, Aymeet. al. 1979, Fryns et. al. 1986, Howard-Peebles and Friedman1986]. …
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Intervention strategies which enable families to be reunified and foster a successful case closure within the County of San Bernardino Department of Public Social Services
… prematurity, low birth weight, pneumonia, congenital malformations, cerebral infarction, and an increased risk to acquired immunodeficiency syndrome.
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Intervention strategies which enable families to be reunified and foster a successful case closure within the County of San Bernardino Department of Public Social Services
… prematurity, low birth weight, pneumonia, congenital malformations, cerebral infarction, and an increased risk to acquired immunodeficiency syndrome.
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
Congenital malformations are the leading cause of infant mortality in the United States, and 2% of all live births have some form of malformation. While many of these malformations have known genetic or environmental causes, others have eluded explanation. These conditions are thought to be caused …
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Textualidad, interpretación y construcción del cuerpo : Políticas ontológicas de la legalización parcial del aborto en Colombia
… by this kind of literature in the case of congenital malformations and sexual abuse.
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Investigating the Epigenetic Mechanism Behind Transgenerational Inheritance in Mice with Abnormal Folate Metabolism
… to an increased likelihood of a wide spectrum of congenital malformations in their wildtype offspring for at least four generations. Folate metabolism is required for DNA synthesis and cellular methylation. Folate and its metabolism have also been linked to spermatogenesis and male fertility. My …
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Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
… of development that, if defective, can lead to congenital malformations incompatible with life. An improved understanding of the cellular and molecular processes that build the heart is essential to elucidate the causes of congenital defects and to design appropriate therapies. Relatively little …
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Multigenerational effects of abnormal folate metabolism on embryo growth and development
… phenotypes including growth defects and congenital malformations. Remarkably, the Mtrrgt mouse line is a model of transgenerational epigenetic inheritance since the congenital malformations persist at least up to four wildtype generations after an Mtrr+/gt maternal grandparent. In …
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Exploring the ecology of Orthobunyaviruses in Virginia and their pathogenesis in murine and poultry models
… ruminants, leading to spontaneous abortions and congenital malformations. As such, CVV is a virus of high economic relevance, but little is known about fundamental aspects of its biology. To address this gap of knowledge, I conducted a series of studies to better understand the pathogenesis and …
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Race differences in infant mortality
… specific cause compared to a reference category (congenital malformations). The results reveal a number of differences in both the presence of significant effects of the variables of interest as well as in the direction and magnitude of the effects, with a greater number of race differences …
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Placental epigenetic modifications and development in valproic acid-induced teratogenesis
… In utero exposure to VPA is associated with congenital malformations and neurodevelopment disorders. VPA exerts its teratogenic effects through epigenetic dysregulation, which interferes with tissue development and function. Evidence suggests that VPA can also cause placental toxicity, which …
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Towards an autologous tissue engineering construct for craniofacial bone repair
… bone defects, as a result of trauma, congenital malformations or tumor resections, generally have limited healing without clinical intervention. The autograft is the current standard of care for repair of these defects due to capacity for osteointegration and immunological …
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Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro
… neurotoxicity. These agents can cause congenital malformations, cognitive deficits and behavioral impairment in children as a result of in utero exposure. The impact of four major AEDs, namely phenobarbital, valproic acid, carbamazepine and lamotrigine, on cell viability, cell cycle and …
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Developmental Malformations in Zebrafish Caused by Exposure to Environmental Pollutants
… and predict environmental chemicals causing congenital malformations. High-throughput screening of 292 unique chemicals from the ToxCast Phase I library identified 38 skeletal disruptor compounds (SDCs) producing bone and craniofacial cartilage malformations in zebrafish. We used ToxCast in …
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Risk Factors associated with high prevalence of stillbirths in Capricorn District, Limpopo Province
… such as cord prolapse, placenta abruption and congenital malformations have a major contribution in high prevalence of stillbirths in Capricorn district Limpopo province. Recommendations: The study recommended that more research on stillbirths needs to be done to address people at risk factors …
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The impact of genetic, environmental and life-style factors on male reproductive function
… the incidence of testicular cancer (TC) and of congenital malformations of male genital organs is significantly higher in Denmark as compared to Finland. Previous studies have shown an association between decreased sperm quality and risk of TC. Recently, it was suggested that poor sperm quality, …
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Mechanisms of monohalogenated acetic acid induced genomic DNA damage
… outcomes including small for gestational age and congenital malformations. While individual DBPs are teratogenic or carcinogenic, because they are formed at low concentrations during disinfection, it is unlikely that any one DBP can account for these increased risks. While genotoxicity and …
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Intergenerational effects of early life programming: the role of glucocorticoids and maternal obesity
… early miscarriage as well as a higher risk of congenital malformations. Maternal obesity has also been recognised as one of the factors capable of ‘programming’ the offspring, increasing the risk of childhood and adult disorders such as obesity and hypertension. In this thesis I have used two …
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Craniosynostosis in a South Africa population
… last group included patients who had additional malformations or clinical findings without a syndromic diagnosis. The prevalence of phenotypic findings, teratogen exposure, birth complications, congenital malformations, surgical interventions and results of genetic testing in this cohort is …
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Developing a stem-cell system of embryonic development organised by a morphogen signaling centre
… and tissues during gastrulation can lead to congenital malformations and even embryonic death. The mechanisms underlying gastrulation are difficult to study in vivo, as gastrulation occurs post-implantation rendering the embryo inaccessible for direct in vivo experimentation. In vitro stem …
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