Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Congenital insensitivity to pain"”.
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Investigation into the molecular mechanisms of congenital insensitivity to pain
Congenital insensitivity to pain (CIP) is an extremely rare inherited disorder characterised by the inability to perceive physical pain from birth, resulting in a number of injuries including self-mutilation, repeated burns and fractures. A number of different genes underlying CIP have been …
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Investigation into the Molecular Biology of Human Genetic Sensory Disorders of Painlessness and Itch
Pain and itch are two distinct unpleasant sensations. Despite having different characteristics, both pain and itch are often disabling, particularly when those sensations persist and result in a chronic condition. Considerable research has been focused on exploring alternative treatment for chronic …
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Distribution and function of TRP ion channels in primary sensory neurons
… exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin …
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Exploring Pain Neurobiology: Molecular Investigation of Genetic Sensory Disorders
… is a neural pathway that underlies our capacity to feel pain when we are threatened by potential tissue injury. Congenital Insensitivity to Pain (CIP) arises when genetic mutations disrupt molecular components that are essential to the development or postnatal function of this system. …
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Charakterisierung der Auswirkungen einer pathogenen Mutation im Neurotrophinrezeptorgen trkA im Zellkulturmodell
… of the action of neurotrophins and their receptors plays an important role. They support survival and differentiation of neuronal cells. The prototypic neurotrophin NGF (nerve growth factor) specifically stimulates the transmembrane receptor TrkA. The TrkA Isoform II, which is expressed in …
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Sensory Neurogenesis and the Role of PRDM12 in Nociceptor Development and Function
Nociceptors are a set of peripheral neurons responsible for the detection of noxious stimuli. They function to alert us to the presence of potentially damaging internal and environmental threats, thereby playing an important role in allowing us to react and avoid danger. Unfortunately, for over 30% …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… sodium channel Nav1.7 has gained traction as a pain target with recognition that loss-of-function mutations in SCN9A, the gene encoding Nav1.7, are associated with congenital insensitivity to pain, whereas gain-of-function mutations produce distinct pain syndromes due to increased Nav1.7 …