Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Congenital abnormalities"”.
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Experiences of parents with congenital abnormalities at Oshakati Intermediate hospital, Oshana region
… the experiences of parents of children with congenital abnormalities and identify source of support such parents employ when dealing with the child born with congenital abnormalities. Congenital abnormalities, regardless of the type, pose a concern to the Government, society, immediate family …
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Disease profile and outcomes of neonates admitted to the paediatric intensive care unit at Red Cross War Memorial Children's hospital in Cape Town, South Africa
… Surgical admissions accounted for most patients. Congenital abnormalities occurred in 50.4% of the cohort. Neonatal mortality at ICU discharge was 10.9% compared to 3.8% in older patients (OR 3.08. CI 1.89 – 5.02; p = <0.001). Congenital abnormalities were the most common group of conditions …
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Doula Support as a Means to Improve Birth Outcomes for Minority Women
… birth, fetal demise, perinatal laceration, and congenital abnormalities than their white counterparts. Continuous labor support by way of doula care has been recommended for all pregnant women as a means to prevent adverse birth outcomes. Despite this, the population most in need of such support …
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History and Technique of Operation of the Mark G.K. Gibbon Type Pump-Oxygenator
… Yet only within the past twenty years have congenital abnormalities of the great vessels been successfully treated surgically. Except for traumatic lesions of the heart, significant sustained progress in the treatment of acquired intracardiac disease waited until 1948. | It has been long …
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An audit of pelvi-ureteric junction obstruction at Red Cross Children's Hospital : a six year review
… junction obstruction is an important cause of congenital renal and urinary tract abnormality. It is the commonest cause of antenatally detected hydronephrosis. The increasing use of antenatal ultrasound as a screening tool for congenital abnormalities in the developing foetus has resulted in a …
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3D Bioprinting of High Cell Density Bioink for Chondrogenic Differentiation in Replacement Tracheal Rings
… from trauma, prolonged intubation, infection, or congenital abnormalities. Severe cases can be life-threatening, significantly impacting the quality of life and leading to respiratory distress. The limitations of existing treatment methods, especially for long-segment tracheal stenosis, mean that …
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Understanding of Intrinsic Sources of DNA Damage that Drive Human Disease: A Foray into the Study of DNA Interstrand Crosslinks and Genome-Embedded Ribonucleotides
… characterized by early bone marrow failure, congenital abnormalities, and an early onset of cancers such as leukemia and head and neck squamous cell carcinomas (HNSCC). On the other hand, failure to appropriately remove genome-embedded ribonucleotides leads to Aicardi-Goutières Syndrome …
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Adverse perinatal events observed in obese pregnant women in the Metro West Region
… dystocia, 5 minute Apgar Score less than 7, congenital abnormalities) observed in obese and morbidly obese compared to normal BMI pregnant women.
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Investigating the control of epithelial polarisation in human kidney organoids
… failures at this stage can lead to a suite of congenital abnormalities that may present as renal dysplasia, hypoplasia or, in extreme cases, complete renal agenesis. In this thesis, I have investigated the control of the PTA-RV transition as it relates to human kidney development, using human …
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Munnur hestsins við frumtamningu : forathugun á íslenskum tamningatrippum
… mucosa and the process of tooth shedding. Severe congenital abnormalities were observed in the tooth shedding in one horse that was consequently excluded from the study. Otherwise, the tooth shedding appeared to be in accordance with descriptions from other breeds in the literature. Thickening of …
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… of DNA crosslinks have been associated with congenital abnormalities, bone marrow and kidney failure, liver dysfunction, and cancer. DNA nucleases play a significant role during the repair of ICLs and they function at multiple repair steps. Here, we assessed the contributions of …
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RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
… Insufficient or excess RA can result in various congenital abnormalities, such as Hirschsprung disease (HSCR). In HSCR, neurons are absent from variable lengths of the gastrointestinal tract due to a failure of neural crest cell (NCC) colonization or development, leading to megacolon and/or the …
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The effects of virus-induced maternal inflammation on methylation patterns in skeletal muscle
… in humans is associated with increased risk for congenital abnormalities. In pigs, maternal infection with porcine reproductive and respiratory syndrome virus (PRRSV) increases inflammatory cytokines in the offspring, influences myogenic gene expression, and decreases total muscle fiber number. …
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Loss of rad51 in zebrafish (Danio rerio): a novel Fanconi anaemia model
… DNA repair disorder characterised by various congenital abnormalities, progressive bone marrow failure and cancer predisposition. The cellular and molecular pathology of FA is poorly understood, resulting in a severe lack of effective treatment options. In this thesis, I describe the first …
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A cross-sectional study of patients presenting to an urban emergency department in Mwanza, Tanzania
… (8.9%), respiratory complaints (3.1%) and congenital abnormalities (3.2%) in the >14 years, 1-14 years and <1 year age groups respectively. Most (63.6%) patients were discharged directly from the ED, and ED and in-hospital mortality were 0.2% and 15.5% respectively. Conclusion: In this …
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Surfactant for the treatment of respiratory distress syndrome in very low birth weight infants at a level 2 hospital: a descriptive retrospective cohort study – safety and efficacy
… of 800g to 1200g. Outborn infants and those with congenital abnormalities were excluded. Results: The total number of patients included in the study was 66. The median birth weight was 965g (Interquartile range (IQR) 880-1060g) with a median gestational age of 28 weeks (IQR 28-29 weeks. The median …
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High resolution DNA copy number analysis of constitutional chromosomal aberrations in human genomic disorders
… mental retardation, often in association with congenital abnormalities (MR/CA). These abnormalities in normal human morphogenesis may express themselves as subtle dysmorphic signs not causing any harm or present as severe disabling and life-threatening malformations such as congenital heart …
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Fancm and Faap24 Maintain Genomic Stability Through Cooperative and Unique Functions
… of clinical manifestations including multiple congenital abnormalities, progressive bone marrow failure and profound cancer susceptibility. A hallmark of cells derived from FA patients is hypersensitivity to DNA interstrand crosslinking agents such as mitomycin C (MMC) and cisplatin, suggesting …
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Assessment of neural tube deffects in two Northern Namibia hospitals: Incidence, seasonal variation, risk factors and prevention strategies for folate sensitive defects
Neural tube defects (NTDs) represent severe congenital abnormalities of the nervous system and are among significant abnormalities associated with a high mortality and morbidity rates. Studies reported that the incidence of NTDs varies worldwide, with the highest found in low-income countries. Most …
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Roles in Retinoid Signaling in the Lower Urinary Tract
… for differentiation of the bladder epithelia. Congenital abnormalities of the kidney and urinary tract (CAKUT) characterize a range of lower urinary tract defects such as kidney and ureter agenesis, hydronephrosis, and vesicoureteral reflux. Development of the lower urinary tract, which …
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