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Showing 1 to 9 of 9 for “"Conformational switching"”.
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Conformational switching in self-assembling mechnical systems : theory and application
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1996.
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Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine
… energy of ATP binding and hydrolysis to power conformational changes that unfold and translocate target proteins into the ClpP peptidase for degradation. X-ray crystal structures show that some ClpX subunits occupy nucleotide-loadable conformations and others occupy unloadable conformations. …
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Quantum dynamical study of Si(100) surface-mounted, STM-driven switches at the atomic and molecular scale
… molecular scale. The first example considers the switching of single H-atoms between two dangling-bond chemisorption sites on a Si-dimer of the Si(100) surface (Grey et al., 1996). The second system examines the conformational switching of single 1,5-cyclooctadiene molecules chemisorbed on the …
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Interactions between Folate Deficiency and β-Nicotinamide Adenine Dinucleotide Deficiency and Conformational Study of Thymidylate Synthase and its Physiological Relevance
… at understanding the physiological relevance of conformational switching of TS was conducted. Phylogenetic evidence supported an evolutionary selection pressure towards conformational switching of TS. Crystal structures suggested that the catalytic thiol of R163K is more susceptible to …
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Structure and Dynamics of AcrA, a Periplasmic Component of a Multidrug Efflux Pump
… that undergoes pH-dependent and reversible conformational changes. AcrA contains an interrupted alpha-helical, coiled-coil domain flanked by a pair of beta-stranded lipoyl motifs, and my SDSL/EPR analysis revealed that the pH-induced conformation change mainly involves the coiled-coil and …
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Quantum mechanical study of molecular switches : electronic structure, kinetics and dynamical aspects
… for latest experimental results aiming at the switching of surface mounted ABs. In some of these experiments, it is assumed that the switching process is substrate mediated, by attaching an electron or a hole to the adsorbate forming short-lived anion or cation resonances. Therefore, we …
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pH-Triggered Membrane Insertion of Proteins
Several classes of membrane proteins refold from their original soluble conformations in response to acidification and insert into lipid bilayers. Despite the recent advances in unraveling the molecular mechanisms of pH-triggered insertion of membrane proteins, many aspects of this process remain …
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Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane
… and studied that are able to perform a drastic conformational flip upon protonation, loosening the stacking of hydrocarbon tails in lipid bilayers. Liposomes constructed from such flipids (fliposomes) can be disrupted by this acid-triggered conformational flip to cause a rapid release of a cargo …
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Synthesis and conformational study of trans-2-aminocyclohexanol-based pH-triggered molecular switches and their application in gene delivery
… neighboring hydroxyl groups, which triggers a conformational flip, and forces changes of the relative position of other substituents on the ring. In this work, a library of TACH-lipids has been designed and built based on structural modifications of both hydrophilic headgroups and hydrophobic …