Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 56 for “"Conformational analysis"”.
-
POLYCYCLIC POLYAMINES: SYNTHESIS AND CONFORMATIONAL ANALYSIS
<p>The synthesis, conformational analysis, and reactivity of a homologous series of tricyclic orthoamides is discussed. The tricyclic orthoformamides, orthoacetamides, orthopropionamides, and orthobenzamides were synthesized by the uncatalyzed condensation of macrocyclic triamines with amide …
-
Conformational Analysis of Cyclohexandiols and Related Compounds
The conformational equilibria in disubstituted cyclohexanes containing polar groups lead to a diversity of conformational forms. In solution, the conformational preference is shown to be highly dependent upon the nature of the solvent. In the cyclohexandiol series, the formation of intramolecular …
-
BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
-
BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
-
Conformational analysis of antibody binding site using EDMA methods /
Euclidean distance matrix analysis (EDMA) methods are used to distinguish whether or not significant difference exists between conformational samples of antibody complementarity determining region (CDR) loops, isolated LI loop and LI in three-loop assembly (LI, L3 and H3) obtained from Monte Carlo …
-
Conjugated polymers and designed interfaces : conformational analysis and applications
… and fluorescence. In this dissertation, the conformational changes and their effects on photophysics in different environments will be discussed. In Chapter 1, the basic principles to understand this thesis will be reviewed, including the processes of absorption and emission, exciton …
-
Conformational analysis and dielectric relaxation of polycarbosilanes and related materials
The conformational characteristics of poly(dimethylsilmethylene), poly(dimethylsilethene), poly(dimethylsilethane) and a related material, poly(2,2,5,5-tetramethyl-1-oxa-2,5-disilapentane), have been investigated using the method of molecular mechanics. In this method, a quantitative analysis of …
-
Conformational Analysis of Disordered Proteins Using H/D Exchange Mass Spectrometry
… regions of both proteins. An H/D-MS study of the conformational dynamics of β-glucuronidase was also conducted. The destabilization of β-glucuronidase that results from the W492G mutation and the partial conformational rescue that results from indole addition were analyzed. A new method to …
-
Conformational analysis of diglycosyl disulphides containing ßS(1-1)S interglycosidic linkages
… or receptors. Therefore, knowledge of the conformational preference associated with glycosidic linkages is required. In this thesis the conformational preferences of the βS( 1-.1 ')8 glycosidic linkage within asymmetrical dissacharide mimetics have been studied using computational methods. …
-
Conformational Analysis of 1-Tertiarybutyl-1, 4-Dihydronaphthalene a Turnover from SRNI to SNI Mechanism
… with the t-butyl group “axial” and “equatorial.” Analysis of chemical shifts and coupling constants was aided by use of a LAOCOON III program. </p>
-
Random search conformational analysis of piperazine and piperadine analogs of GBR12909 : implicit aqueous solvation effects
… work was to study the effect of solvent on the conformational potential energy surface (PES) of GBR12909 analogs. Local minima on the PES's were found by the Random Search algorithm using the Sybyl molecular modeling package from Tripos, Inc., and an implicit solvent model. Two …
-
C8-Arylguanine Modified Hairpin Oligonucleotides: Synthesis, Conformational Analysis, and Tools for the Investigation of Z-DNA Formation
… conformation. Here we sought to determine the conformational effects of a hairpin oligonucleotide sequence (d(CG) 5T4(CG)5) containing only one C8-arylguanine modified base to compare with our previous results.;Synthesis of C8-arylguanine modified hairpin oligonucleotides began at the …
-
Application of electron spin resonance spectroscopy to problems of structure and conformational analysis: polysemiquinones and macrocyclic semidiones
… of dipolar relaxation to the overall linewidth;Conformational motion in macrocyclic semidiones derived from acyloins of paracyclophanes has been investigated. ESR spectra for the E-semidione derived from 1,4-(5'-hydroxy-6-ketodecamethylene)-benzene reveal a rigid, asymmetric structure at …
-
Incorporation of Cα,α-Disubstituted Amino Acids into Model Peptide Systems: Conformational Analysis and Possible Applications as Therapeutic Agents
A diverse set of human diseases is associated with the misfolding of proteins into insoluble fibrillar structures that have predominantly β-sheet secondary structure. Thus it is imperative to elucidate the structural elements that contribute to β-sheet formation and stability. Peptides that …
-
SYNTHESIS, BIOLOGICAL ACTIVITY AND CONFORMATIONAL ANALYSIS OF FRAGMENT ANALOGUES OF ALPHA-MELANOTROPIN (PEPTIDE, STRUCTURE-FUNCTION, PHENYLGLYCINE, NMR, TETRAHYDROISOQUINOLINE-3-CARBOXYLATE).
… enhanced potency. In this regard, a series of conformationally restricted linear and cyclic fragment analogues of α-MSH have been prepared and carefully analyzed by both biological and biophysical methods. Conformational restriction was incorporated in α-MSH fragment analogues, by: (1) …
-
Effiziente Konformationsanalyse von Peptiden
Conformational analysis by NMR spectroscopy and molecular dynamics simulations (MD) is one of the most important techniques for high resolution structure analysis in chemistry and biochemistry. In the frame of this thesis, a torsion angle based clustering procedure forms the basis of an enhanced …
Page 1 of 3