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Showing 1 to 20 of 1296 for “"Conformational"”.
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Conformational Studies on Alicyclic Alcohols
… on their preferred conformations.<br/><br/>The conformational preference of the hydroxyl group in cyclohexanol is determined by the concentration vs. chemical shift method and compared with other standard NMR methods, namely: peak area measurement at low temperature; chemical shift of the …
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Conformational Requirements for Cyclopropyl Conjugation
Made available in DSpace on 2014-12-09T17:35:47Z (GMT). No. of bitstreams: 1 6711918.pdf: 4302796 bytes, checksum: 4d0648833b39faa8a6c750b827999c48 (MD5) Previous issue date: 1967
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Conformational studies of lithium phenyl stearate.
… As the temperature is increased the number of conformational defects increases continuously, until at <130°C the chain reaches an isotropic degree of disorder. At this point the phase transition begins, so the chain reaches liquid like disorder before the phase transition begins.Modelling …
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POLYCYCLIC POLYAMINES: SYNTHESIS AND CONFORMATIONAL ANALYSIS
<p>The synthesis, conformational analysis, and reactivity of a homologous series of tricyclic orthoamides is discussed. The tricyclic orthoformamides, orthoacetamides, orthopropionamides, and orthobenzamides were synthesized by the uncatalyzed condensation of macrocyclic triamines with amide …
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Protein structure prediction and conformational transitions
… phosphorylation, proteins can undergo obvious conformational changes. It is challenging to characterize these changes because of the high flexibility of phosphorylation regions and the difficulties in obtaining diffraction quality crystals. In the current study, we focused on the conformational …
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Tau Aggregation, Conformational Selection, and Inhibition
… Tau exists as a disordered monomer in dynamic conformational equilibrium. This solution-phase heterogeneity could, in part, explain conformational diversity of Tau fibrils.</p> <p>A homogeneous set of Tau fibrils transitioned to a new heterogeneous population of conformers after multiple cycles …
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Conformational Effects of Stereoselective Photochemical Isomerizations
Made available in DSpace on 2014-12-09T17:36:49Z (GMT). No. of bitstreams: 1 7021004.pdf: 4933093 bytes, checksum: e9eb0ca1133273d512299de904b7befe (MD5) Previous issue date: 1970
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Mesoscopic modeling of protein conformational changes
"The conformational changes of proteins are studied theoretically with the help of coarsegrained mesoscopic models of protein structure. The models explicitly incorporate the effects of the polarity of the peptide backbone and of the specificity of hydrophobic interactions. These two features are …
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Systematic conformational search with constraint satisfaction
… This thesis describes a systematic method for conformational search, an application of the method to determining the structure of the formyl-Met-Leu-Phe-OH (fMLF)peptide by solid-state NMR spectroscopy, and a separate project to determine the structure of a protein-DNA complex by X-ray …
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Conformational Analysis of Cyclohexandiols and Related Compounds
The conformational equilibria in disubstituted cyclohexanes containing polar groups lead to a diversity of conformational forms. In solution, the conformational preference is shown to be highly dependent upon the nature of the solvent. In the cyclohexandiol series, the formation of intramolecular …
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Using Protein-Likeness to Validate Conformational Alternatives
… used structure validation techniques to validate conformational alternatives in a variety of settings. First, I extended previous work introducing the backrub, a local, sidechain-coupled backbone motion, by demonstrating that backrubs also accompany sequence changes and therefore are useful for …
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Conserved Conformational Dynamics Control PTP1B Enzymatic Activity
The long-accepted paradigm of biochemistry is that enzyme function depends on the three-dimensional (3D) structure. However, this paradigm is changing. Namely, the emerging view is that protein function also depends on intrinsic protein dynamics. Further, while sequence conservation is …
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Simulations of carbohydrate conformational dynamics and thermodynamics
In this thesis, free energy calculations are employed to establish the conformation freedom of selected carbohydrates. The focus is on the biologically important (1-4)-linked glucans, although the α(1-1) α and α(1-6) linkages are also investigated. Two principal types of potential of mean force …
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Physical Studies of Actin Nucleation and Conformational Dynamics
Actin is a 42 kilodalton ATPase that exists ubiquitously in eukaryotic cells. Unlike other ATPases, however, actin, under suitable conditions, can polymerize, forming helical filaments. Cells, in orchestrating their myriad cellular processes, utilize actin's intrinsic capacity to polymerize, but do …
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Agonist-Induced Conformational Changes In The Nmda Receptor
… and glutamate molecules and undergo a series of conformational changes that results in the opening of a cation-permeable pore in the neuronal plasma membrane. Various aspects of NMDA receptor function are not fully understood, including the phenomenon of negative cooperativity between the …
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Fluorination Effect on the Conformational Properties of Alkanes
… temperature-dependent studies and quantified the conformational difference.
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The acetanilide crystal structures: packing and conformational similarities
… similarities using the XPac algorithm and conformational preferences were assessed. Chapter 4 presents the crystal structures and their structural similarities, whilst Chapter 5 focuses on the theoretical conformational analysis. Three amide-amide hydrogen bond geometries and a molecular …
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