Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Conditioned Place Preference"”.
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Zebrafish and Conditioned Place Preference: A Translational Model of Drug Reward
… disorder). Behavioral quantification within the conditioned place preference (CPP) paradigm serves as a measure of the rewarding qualities of a given stimulus (e.g., drug). If animals develop an increase in preference to spend time in an environment that had previously been paired with drug …
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Cocaine conditioned place preference : expression, endurance, extinction, and drug-induced reinstatement
… maintenance, and extinction of a cocaine-induced conditioned place preference was studied using a three-chamber 'unbiased' apparatus. During training, rats were given four 20 minute pairings of one chamber with cocaine (Experiment 1, 3 and 4: 10 mg/kg, IP; Experiment 2: 5, 10, and 20 mg/kg, IP) …
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Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of
… nicotinic receptors within the aVTA. Using the conditioned place preference paradigm (CPP), the present study evaluated the muscarinic versus nicotinic involvement in intra-VTA carbachol-induced CPP learning by administering atropine (muscarinic antagonist) and mecamylamine (nicotinic …
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Effects of Norharmane and Nicotine on the Conditioned Place Preference of Mice
… been used. Thus, the present study utilized a conditioned place preference paradigm to observe whether or not nicotine at dose levels of 0.15 and 0.30 mg/kg, and norharmane at dose levels of 5.0 and 10.0 mg/kg, could individually produce place preference, indicating drug seeking behavior of the …
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THE EFFECT OF NALTREXONE ON NICOTINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS
… studied in animals through self-administration, conditioned place preference, and other approaches that enable researchers to assess nicotine cessation strategies. One strategy involves the use of opioid receptor antagonists. For instance, naloxone has been shown to reduce place preference for …
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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents
… (mGluR) antagonists can block the induction of conditioned place preference (CPP), a measure of cocaine seeking behavior, but their functions after clinically relevant withdrawal periods are not known. Our study showed that group I mGluR antagonists failed to block the expression of …
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Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference
One of the biggest problems facing cocaine addicts is relapse and currently there are no treatments for relapse. These studies will provide insight into the underlying mechanisms of LTP mediating relapse to cocaine. A major mechanism of cocaine in addiction is to inhibit dopamine re-uptake and …
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Locomotor sensitization and conditioned place preference for amphetamine in late adolescent and adult male and female rats /
… on the location at which the status contest took place. Pre-game testosterone and self-confidence levels were significantly higher prior to games played in the home venue. In contrast, pre-game somatic and cognitive anxiety levels were significantly higher prior to games played in the away venue. …
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Effects of physical exercise and exercise-induced adult hippocampal neurogenesis on conditioned place preference for cocaine in mice
… causally related to accelerated extinction of conditioned place preference (CPP) for cocaine from exercise in male C57BL/6J mice. Since the conditioned place preference paradigm represents the major behavioral assay I employ in the proposed experiments, Chapter 1 presents a review of the …
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INVESTIGATING THE ROLE OF α6 and α4 CONTAINING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN NICOTINE AND COCAINE CONDITIONED PLACE PREFERENCE TESTS IN MICE.
… in nicotine and cocaine reward using an unbiased conditioned place preference (CPP) test in mice. Adult male C57BL/6J mice or male mice null for the α6 or α4 nicotinic receptor subunit were used. For CPP: On day 1, pre-conditioning scores were recorded; Days 2-4 mice underwent conditioning, where …
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Chronic Stress during Adolescence Alters Alcohol-Induced Conditioned Place Preference in Mice Selectively Bred for High Alcohol Preference but no Low Alcohol Preference
… days after stress exposure, all subjects began a conditioned place preference (CPP) paradigm, a behavioral task that measures the sensitivity to alcohol's rewarding effects. Since re-exposure to a stressor has been associated with an increased risk in relapse and other drug-seeking behaviors, half …
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The effects of dopamine D1 and D2 antagonists on cocaine-induced CPP in preweanling rats
The effects of dopamine D1 and D2 antagonists on conditioned place preference (CPP) and locomotor activity were assessed. A total of three experiments were conducted. In each experiment there were two conditioning days followed by a test day. The results indicate that DA D1 and D2 receptors have …
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The effects of dopamine D1 and D2 antagonists on cocaine-induced CPP in preweanling rats
The effects of dopamine D1 and D2 antagonists on conditioned place preference (CPP) and locomotor activity were assessed. A total of three experiments were conducted. In each experiment there were two conditioning days followed by a test day. The results indicate that DA D1 and D2 receptors have …
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Investigating prefrontal cortex neuronal signatures of opioid-induced risk-taking behavior
… conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in …
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Taurine's effect on cocaine reward and neurogenesis in the adolescent male rat brain.
… in attenuating the reward value of cocaine in a conditioned place preference paradigm, independent of hormonal status. Taurine has also been shown to be a neuroprotectant and neurogenic. In these studies, taurine was tested as a protectant against cocaine reward by increasing neurogenesis in the …
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