Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Computational immunology"”.
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Fine-tuning Boltz for Antibody-Antigen Binding Prediction
… binding is a central challenge in computational immunology. Its direct implication for therapeutic antibody design and vaccine development has made it one of the most rapidly growing fields. Recent advances in protein language models and structure prediction have provided new tools …
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Transdisciplinary Strategies to Study the Mechanisms of CD4+ T cell Differentiation and Heterogeneity
… dissertation exemplifies how a combination of computational modeling with experimental immunology can efficiently advance the scene on CD4+ T cell differentiation. In this thesis I present i) an overview on CD4+ T cell differentiation and an introduction to which computational strategies have …
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Computational Methods to Design Broad-Spectrum Medical Countermeasures Against Antigenically Diverse Pathogens
… and treatments. This dissertation explores how computational approaches, such as graph-based and deep learning methods, can be used to design broad-spectrum vaccines and antibodies that are effective against a wide range of pathogen variants. I focus on two complementary projects: 1) designing …
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Intratumoral B and T cell receptors: reconstruction and analysis
… advances in genomics, cancer biology, and computational sciences. In particular, significant research effort is undertaken in the field of cancer immunotherapy, where the immune system is stimulated to recognize and attack cancerous cells. In this thesis, I investigate certain aspects of …