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Showing 1 to 4 of 4 for “"Compritol"”.
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… lipid matrices of diclofenac sodium (Df-Na)/Compritol® 888 ATO (888 ATO) prepared using different approaches such as ‘cold’, ‘hot’ and pre-mix’ by applying changes in processing temperature, drug/lipid ratio and composition of the formulation processed by HME and subsequent compression into …
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Implementing process analytical technology (PAT) tools for the analysis and control of manufacturing processes during hot-melt extrusion
… (PMOL) was processed with ethyl cellulose (EC) - Compritol 888 ATO (C888) polymer/lipid blends to produce sustained release drug formulations. The aim of this study was to optimize HME processing by using design of experiment (DoE) and to monitor the process using in-line NIR spectroscopy. Input …
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Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
… combination of 85% glyceryl monostereate and 15% compritol ATO 888. The particle size, zeta potential and entrapment efficiency of the HT-SLN’s was 225 nm, -21 mV and 85% respectively. Although the dose administered in the animal study was approximately 16-fold lower than the HT-Film, SLN’s …