Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Compound screen"”.
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
… PAX3, we performed a high-content chemical compound screen and identified novel signalling pathways important for trigeminal development. We thus obtained an organoid enriched in trigeminal progenitors, which, when cultured over time, developed into trigeminal sensory neurons. …
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A pathways-based approach identifying determinants of drug resistance in oesophageal adenocarcinoma
… between the two groups. A focused siRNA screen of 80 target genes identified from the GSEA results was then devised and completed, highlighting the role of Src in chemotherapy non-responders. A compound screen of FDA-approved drugs was carried out in the OE33 and FLO-1 cell lines in …
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Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis
… cells. We performed a high-throughput compound screen utilizing a repurposing drug library. We identified that ritanserin, a diacylglycerol kinase alpha (DGKA) inhibitor, synergizes with Chloroquine (CQ) to selectively inhibit proliferation of TSC2-deficient mouse embryonic fibroblasts …
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IN VITRO SUSCEPTIBILITY OF CHLAMYDIA TRACHOMATIS TO LPS-BINDING POLYAMINES AND CELLULOSE ETHER POLYMERS: TOWARDS THE DEVELOPMENT OF A MICROBICIDE AGAINST CHLAMYDIA INFECTION
… in the development of novel anti-Chlamydia compounds. In my effort to identify compounds that can be considered as microbicide candidates, I developed two automated methods for enumeration of Chlamydiathat are amenable to a large-scale study. The automated immunofluorescence image based …