Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Compound discovery"”.
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Lead compound discovery for myotonic dystrophy
… for characterization of rationally-designed compounds and the development of a fluorescence anisotropy assay for a high-throughput screening of the NCI Diversity Set III compound library. From such studies I was able to identify several lead compounds that are successful at inhibiting the …
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Compound discovery and expression of a putative cathepsin D-like protease in Trichomonas vaginalis
<p>Trichomonas vaginalis is a sexually-transmitted parasite that is the causative agent in the disease trichomoniasis. Resistance to the only FDA-approved medication to this disease, metronidazole, has been on the increase giving rise to the need for finding targets for new inhibitors to exploit. …
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Structural and biochemical studies on tailoring enzymes involved in ribosomal peptides biosynthesis
… have been dedicated in developing antimicrobial compounds to combat the micro-enemies. Despite the efforts, the resistant strains keep emerging with the introduction of new therapeutic compounds, which implies an urgent need for compounds with modified or novel scaffolds to overcome the …
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Practical applications of genomics to natural product discovery and biosynthesis
… of natural products, and a pitfall of synthetic compound libraries, is the remarkable diversity of structure and chemical group functionality that discloses them as Nature’s handiwork and is critical for the bioactivities that many of them possess. Despite this precedent, characterization of new …
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Towards ultrahigh-throughput phenotypic screening using microfluidic droplets and functionalised polyacrylamide beads
… for naïve phenotypic screening and drug lead compound discovery. In this thesis, I will first present my work in characterising and enhancing protein immobilisation on these beads using a fully covalent, suicide substrate-based linkage module we developed …