Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Compound 1"”.
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Antidiabetic activity of Schkuhria pinnata – Biological screening, PK analysis and mode of action
… active extract and attempt to isolate an active compound(s). An aqueous freeze dried extract was found to be the most active at stimulating glucose uptake activity in C2C12 and Chang cells. Fractionation of this extract in an attempt to identify the active compound yielded a novel crystalline …
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In vitro modelling of cellular haemozoin and inhibition by β-haematin inhibitors and their derivatives
… haem amounts as a function of intracellular test compound amounts at the IC50 values of these β-haematin inhibitors highlighted that there was an apparent 1:1 relationship with the amount of intracellular exchangeable haem, indicative of complex formation. Transmission electron microscopy images …
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Molecular Probes for Biologically Important Molecules: A Study of Thiourea, Hydroxyl radical, Peroxynitrite and Hypochlorous acid
… of 1,8-bis(phenylthioureido) naphthalene (compound 1) as a fluoride sensing molecule. Compound 1 showed a remarkable 40 fold enhancement in fluorescence with 5 eq of fluoride addition. Compound 1 also showed possibility of visual colorimetric sensing with fluoride. Free radical mediated …
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Spectroscopic characterization of iron-oxygen intermediates in human aromatase (CYP19A1)
… that an oxo-ferryl π-cation radical, known as “Compound 1” in P450 chemistry is the reactive intermediate that catalyzes most of the reactions of P450s. The identity of the reaction intermediate that catalyzes the terminal step estrogen biosynthesis by CYP19A1 is still a mystery. There is …
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Oxyligands in triosmium carbonyl cluster compounds
… a triply bridging tridentate coordination mode. Compound 1 is fluxional, and hydride migration was established as the low barrier dynamic process. Solid/solution structure equivalence for this class of clusters was demonstrated.
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Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease.
… using both acid chloride (N-decanoyl cysteamine (Compound 1), N-decanoyl L-cysteine ethyl ester (compound 3)) and peptide coupling based reactions, and full characterisation has been achieved. The nitration stage of synthesis was achieved using tert-butyl nitrite and 'fuming' NO as the nitrating …
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1-(1H-pyrrol-2-yl)-1,2-propandione is a crucial pheromone component of the rare North American cerambycid beetle Dryobius sexnotatus
The compound 1-(1H-pyrrol-2-yl)-1,2-propanedione was recently found to be an important pheromone component of several Asian species of longhorned beetles in the subfamily Cerambycinae. Here, we report the first confirmed identification of this pyrrole as a pheromone component of a cerambycine …
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Organometallic and Inorganic Derivatives of the Tetrathiometallates
… $\sb2$ and (Ph$\sb4$P)$\sb2$WS$\sb4$. Compound 1 was found to exhibit extensive ligand substitution chemistry, involving organophosphines, CO, and $t$-BuNC. It was found that 1 could only support two strongly $\pi$-acidic CO ligands; ((PPh$\sb3$)(CO)Rh) $\sb2$WS$\sb4$ was found to be …
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Aminodiboranates: syntheses, structures, and applications for chemical vapor deposition
… structure can be attributed to packing effects. Compound 1 reacts at elevated temperatures (80–110 °C) to produce (NMe₂BH₂)₂ and the mixed aminodiboranate/tetrahydroborate complex Th(H₃BNMe₂BH₃)₂(BH₄)₂; the reaction proceeds through the Th(H₃BNMe₂BH₃)₃(BH₄) intermediate. The structure of the …
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Synthesis characterization, and reactivity of ruthenium maltolato complexes
… catalysts, particularly inaqueous media. The compounds Ru(ma)2(PPh3)2 (1), Ru(ma)2(DMS0)2 (2), Ru(ma)2(COD) (3) and RuH(ma)(C0)(PPh3)2 (4) (where Hma is maltol) were prepared by the interaction of potassium maltolate with RuC12(PPh3)4, RuC12(DMS0)4, [RuC12(COD)ln, andRuHC1(C0)(PPh3)3, …
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Separation of close isomers by enclathration
The selective inclusion properties of the host compound 1, 1-bis-( 4- hydroxyphenyl)cyclohexane were investigated. This host readily forms inclusion compounds with the isomers of phenylenediamine, benzenediol, picoline and lutidine, as well as selected solvents including methanol, ethanol, …
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Glucose and Glucosamine Derivatives as Novel Low Molecular Weight Gelators
… in organic solvents or aqueous solution. These compounds rely solely on noncovalent forces to form the fibrous networks necessary to entrap a variety of solvents. The organogels and hydrogels thus formed could have applications in a variety of fields from environmental to biological to …
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Synthesis and Characterization of New Cyclic and Acylic Ferrocene Peptide Conjugates
… products were obtained. A suitable crystal of compound 3 was grown from CHCl₃ which shows a number of intra and intermolecular hydrogen bonding interactions between peptides strands. In addition, the system [Dpp-Fc]₂ (1) was syntheised by refluxing Dpp and Fc[COCl]₂ in dichloromethane. A …
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Cytochrome c peroxidase : its role in nitrosative stress and purification as a GST-fusion protein
… species with an absorption spectrum identical to compound I/II at a ONOO(H)/CCP ratio of 1.65 ± 0.10. Titration of the CCP species formed with ferrocytochrome c, gives a ratio of ferrocytochrome c/CCP = 1.87, indicating that the species formed is compound I. An estimate of the second-order rate …
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Nitric oxide reactivity of manganese, iron and cobalt tropocoronands and development of fluorescent aminotroponiminates for nitric oxide sensing
… (2) tropocoronand complexes are described. Compound 1 reacts with one equivalent of NO to form the trigonal bipyramidal (FeNO)7 complex 3, which contains a linearly coordinated nitrosyl (Fe-N-O = 174.3(4)). EPR and M6ssbauer spectroscopy, SQUID susceptometry and normal coordinate analysis …
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Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents.
… of the combretastatin extended family of compounds in the late 1970's and early 80's, there has been an accelerated interest in vascular targeting as a possible cancer treatment methodology. Two natural products, combretastatin A-1 (CA1) and combretastatin A-4 (CA4) interfere with the …
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Synthesis and Structure of Polyoxoanion Supported Organorhodium (I) and Organoiridium (I) Complexes
… five (C$\sb8$H$\sb $)Ir$\sp+$ units. Reaction of compound 1 with 3 eq of (Nb$\sb2$W$\sb4$O$\sb )\lbrack(n$-C$\sb4$H$\sb9)\sb4$N) $\sb4$ in acetonitrile followed by addition of 1 eq of acetic acid results in the formation of $\{\lbrack({\rm C\sb8H\sb )Ir\rbrack\sb2H(Nb\sb2W\sb4O\sb …
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Leishmanicidal, anti-inflammatory and anti-obesity properties of natural products from common medicinal and edible plants.
… This research showed leishmanicidal natural compounds isolated from Cichorium intybus L. (Asteraceae), Cornus florida L. (Cornaceae), Eryngium foetidum L. (Apiaceae), which have been used traditionally as antiparasitic remedies. The roots of C. intybus (chicory) yielded four sesquiterpene …
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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence and Therapeutic Activation
… generation PAC-1 analog [Procaspase activating compound-1 (PAC-1; Vanquish Oncology)] revealed that L14R8-induced cell death was specific to CLL cells and was independent of prognostic markers and microenvironmental factors. Mechanistically, L14R8 acted through direct activation of executioner …
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Electrochemical detection of chemical warfare agents
… with TFA/Et₃N mixture in dichloromethane. Compound 2 reacted with alkylating agents like MeI, EtI, EtSCH₂CH₂Cl (MA) and (CN)(EtO)₂P(O) (NA) to form MeNH-Fc-COOMe (3), EtNH-Fc-COOMe (4), EtSCH₂CH₂NH-Fc-COOMe (5), (EtO)₂P(O)NH-Fc-COOMe (6), respectively. Cyclic voltammetry (CV) of these …
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