Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"Complex traits"”.
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Pleiotropy in complex traits
… studies (GWAS) have uncovered thousands of complex trait loci, many of which are associated with multiple phenotypes. The dedicated study of these pleiotropic effects is becoming increasingly common due to the availability of sample collections with high-dimensional phenotype data, such as …
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Molecular mechanisms controlling complex traits in yeast
… can lead different phenotypes for two traits: gene essentiality and agar adhesion. We found that the genomes of the S288c and [summation]1278b strains are only as divergent as two humans in the population. However, analyses of deletion libraries in each strain revealed 57 genes have …
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Phenomics enabled genetic dissection of complex traits in wheat breeding
… from genotypes is a difficult problem due to the complex nature of genomes, the environment, and their interactions. While the recent advancements in genome sequencing technologies have provided almost unlimited access to high-density genetic markers, large-scale rapid and accurate phenotyping of …
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Slc39a8/zip8 Influences Complex Traits By Regulating Metal Ion Metabolism
… significantly associated with a variety of traits in human, and SLC39A8 loss-of-function results in developmental defects in multiple organs of both human and mice. SLC39A8 encodes ZIP8, a metal ion transporter best known for transporting manganese (Mn) and zinc (Zn), two essential nutrients …
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Modelling human complex traits with regression and neural-network based methods
… insights into the genetic underpinnings of complex disease risk and trait variation. After reviewing the necessary background material, this work consists of three research chapters. The organising theme of these is the building of genotype-phenotype maps, which grow from the simple …
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Dissecting the Genetic Basis of Convergent Complex Traits Based on Molecular Homoplasy
… of my thesis is to understand the genetics of a complex behavioral trait, vocal learning, which serves as a critical substrate for human spoken language. With the available genomes of 23 mammals, I developed a novel approach based on molecular homoplasy to reveal Single Non-random Amino Acids …
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Functional and cross-trait genetic architecture of common diseases and complex traits
… new methods for learning about diseases and traits from genetic data. First, I introduce a method for partitioning heritability by functional annotation from genome-wide association summary statistics, and I apply it to 17 diseases and traits and many different functional annotations. Next, I …
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Integration of common and rare genetic variation across complex traits and neuropsychiatric disorders
… of ultra-rare variation and associations with complex traits and diseases. However, there has been relatively little progress integrating the insights from studies of common and rare genetic variation. In this thesis, we present methods and applications aimed at bridging this divide. Chapter 1 …
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Japanese courage: a genetic analysis of complex traits in medaka fish and humans
… to its utility for the genetic mapping of complex traits, including: the panel's evolutionary relationship with other previously-established inbred medaka strains; the degree of homozygosity in the inbred lines; the rate of linkage disequilibrium decay across the panel; and the genomic …
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Using molecular QTLs to identify cell types and causal variants for complex traits
… associations have been discovered for many human complex traits, and yet for most associated loci the causal variants and molecular mechanisms remain unknown. Studies mapping quantitative trait loci (QTLs) for molecular phenotypes, such as gene expression, RNA splicing, and chromatin …
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POPULATION GENETIC APPROACHES FOR THE STUDY OF COMPLEX TRAITS: FOCUS ON INFECTIOUS AND AUTOIMMUNE DISEASES
… IFIH1, was studied in detail: we revealed a complex selective pattern in human populations distributed in different geographic locations. Nonetheless, the analysis of IFIH1 variants involved in the susceptibility to type 1 diabetes indicated that they have evolved neutrally. Finally, we show …
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DISSECTING THE POLYGENIC LANDSCAPE OF HUMAN COMPLEX TRAITS AND DISEASES IN A SOUTHERN ITALIAN COHORT
Complex traits and diseases are shaped by the combined effects of common and rare genetic variants, yet their contribution to risk is still poorly characterised in Southern European populations. This thesis addresses this gap by analysing the genetic architecture of traits and diseases in Italy, …
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Component interaction in relation to mean expression of complex traits in a field bean cross
Thesis (M.S.)--Michigan State University of Agriculture and Applied Science. Dept. of Farm Crops, 1961
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Mapping Genes for Complex Traits: Obesity, Diabetes, Hypertension, and Dyslipidemia on the Pacific Island of Kosrae
… in human genetics is to map genes for common, complex diseases. For powerful mapping of such phenotypes, the suggestions are to analyze the underlying quantitative traits with covariate corrections in large extended pedigrees with multipoint analysis. This is virtually impossible to do with the …
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Leveraging biological pathways and gene networks to understand the genetic architecture of diseases and complex traits
… score regression to 42 independent diseases and complex traits (average N=323K) to identify enriched annotations. We demonstrate gene network connectivity is highly informative for disease architectures, but the information in gene networks may be subsumed by regulatory annotations, such that …
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When the Map Fails the Territory: Hidden State Models, Complex Traits and the Evolution of Bird Migration
… comparative methods often rely on simplifying complex biological traits into discrete categories, potentially obscuring evolutionary patterns and generally limiting inferences. This dissertation confronts this ``map versus territory" problem by developing and evaluating methodological …
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Integration of bioinformatics approaches to study transcriptome patterns associated with complex traits at the gene and isoform levels
The student, Pan Zhang, accepted the attached license on 2021-03-21 at 20:12.
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Predictive genomics in asthma management using probabilistic graphical models
Complex traits are conditions that, as a result of the complex interplay among genetic and environmental factors, have wide variability in progression and manifestation. Because most common diseases with high morbidity and mortality are complex traits, uncovering the genetic architecture of these …
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