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Showing 1 to 2 of 2 for “"Complex segregation analysis"”.
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Exploring the impact of polygenes on genetic inheritance model identification, with application to Familial Colorectal Cancer Type X (FCCTX)
… models. Exploring this topic involved complex segregation analysis on real FCCTX cancer registry data, then on simulated data (based on the real data characteristics) to determine what caused the model to be identified. If a strong polygenic effect is present, finding evidence for the …
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A Comprehensive Genetic Risk Model for the Prediction of Future Prostate Cancer
… BRCA2 PVs. Through systematic review and meta-analysis of 20 publications, I estimated a pooled PCa relative risk (RR) of 3.42 (95% confidence interval [CI] 2.81-4.17) for HOXB13 G84E carriers. Based on complex segregation analysis of family history data on 11,983 genotyped PCa patients, the …