Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"Complex Disease"”.
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Principled "convergence" non-coding rare variant association testing in complex disease
Although many genetic loci pertinent to complex diseases have been identified and despite the fact that complex diseases remain an immense burden to healthcare globally, many details about the mechanism of these diseases are still unknown. Thus far, genome-wide association studies (GWAS) have only …
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Learning on the Graph: Link Prediction, Multi-label Learning, and Applications to Integrative Complex Disease Studies
<p>Most of the common human diseases, such as cancer, diabetes, and Alzheimer's disease, are consequences of the abnormality of multiple cellular components and the perturbation of their intricate interactions. The emerging network-based approaches offer a unique framework for understanding the …
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Power Analysis and Extension of a Robust Test of Linkage and Association of Human Complex Disease Genes
… work is a modern approach for gene mapping of complex human diseases, the Transmission/Disequilibrium Test (TDT). My studies demonstrate that the TDT is a robust, nuclear family based analysis that can test linkage in the presence of association. I show the advantages and disadvantages of the …
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TRANSLATIONAL GENOMICS: THE IMPACT OF GENETIC RISK SCORE ON PATIENTS AND PHYSICIANS
… of associations between genetic markers and complex disease risk. When several of these markers are used in combination, the predictive performance is strong; however, the clinical utility of multi-marker tests is not known. This thesis addresses a unifying question: Can genomic test results …
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GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY
Type 2 Diabetes is a complex disease characterized by a combination of environmental, lifestyle, and genetic factors. This study seeks to explore the genetic component of diabetes risk through evaluation of a candidate gene, ADIPOQ, encoding the adiponectin protein. Adiponectin is an adipocytokine …
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GENETIC VARIATION OF TYPE 2 DIABETES AND NEPHROPATHY ACROSS ETHNIC GROUPS
Type 2 diabetes mellitus is a complex disease characterized by insufficient insulin secretion and action in the body. Diabetes and associated comorbidities represent significant health burdens throughout the world due to resultant direct and indirect complications. In the United States, the …
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Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa
Oesophageal squamous cell carcinoma (OSCC) is a complex disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research …
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Statistical and Computational Methods to Dissect Ancestry-Biased Germline Effects in Lung Cancer
Lung cancer is a complex disease influenced by a variety of genetic and environmental factors. The germline mutations associated with the disease vary greatly between the East Asian and the European populations. We explore these differences by analyzing genome-wide association study summary …
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Shared Haplotype Length Regression and Its Application
The inherent multidimensional nature of complex genetic diseases calls for the development of new statistical methods designed to discover some components of the “missing heritability” problem. Here, we develop and explore the performance of a novel statistical approach based on haplotype sharing …
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Understanding Inflammatory Bowel Disease using High-Throughput Sequencing
… towards understanding the causes of common disease. Across a wide range of complex disorders there have been hundreds of associated loci identified, largely driven by common genetic variation. Now, with the advent of next-generation sequencing technology, we are able to interrogate rare and …
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Body image/imagining bodies: Trauma, control, and healing in graphic memoirs about anorexia
… are written from those who interact with disease in various capacities from patient, to doctor, to caregiver. This project closely examines three graphic pathographies written about the eating disorder anorexia nervosa. Prior writing, both fictional and personal memoir, on anorexia has …
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Elucidating the Relationship Between Macrophages and Synovial Mesenchymal Progenitor Cell Chondrogenesis
Osteoarthritis (OA) is a complex disease affecting articular cartilage and joint tissues. Macrophages in OA synovium contribute to the inflamed joint environment by releasing inflammatory mediators promoting cartilage loss. What remains unknown is how macrophages interact with synovial mesenchymal …
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Mouse models of osteoarthritis and joint injury
… Americans are affected by osteoarthritis, a complex disease characterized by degenerative lesions to the articular cartilage and subchondral bone in the joints. The complexity of the disease makes the use of human models impractical and complicated. Therefore, various animal models have been …
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Association of nutrition education with the delay of the conversion of pre-diabetes to diabetes in hyperglycemic veterans
Diabetes is a multi-factorial, complex disease where lifestyle changes including diet and exercise can play a pivotal role in its prevention and management. This retrospective study determined the effectiveness of an outpatient nutrition education program in preventing/delaying the diagnosis of …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
<p>Pulmonary hypertension (PH) is a progressive disease with serious effects on quality of life and life expectancy of patients. PH is a complex disease that likely develops due to multiple influences, and no curative treatments exist for this disease. It has been shown that alternative …
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Identification of Differentially Expressed Gene Modules in Heterogeneous Diseases
… associations between biomolecules and human diseases. This is a great advance for science and medicine since it helps to unravel the mechanisms of the diseases and gives clues for new treatment approaches. At the same time, a tremendous amount of raw experimental data and biomedical knowledge …
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Robust numerical methods to solve differential equations arising in cancer modeling
Cancer is a complex disease that involves a sequence of gene-environment interactions in a progressive process that cannot occur without dysfunction in multiple systems. From a mathematical point of view, the sequence of gene-environment interactions often leads to mathematical models which are …
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A GPU program to compute SNP-SNP interactions in genome-wide association studies
… (SNPs) have proven to uncover the underlying complex disease traits. Computing the disease risk based on the interaction effects of SNPs on a case - control study is a difficult problem. As another part of the thesis, a fast GPU program that can calculate the chi-square statistics of SNP-SNP …
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Developing Bottom-Up, Integrated Omics Methodologies for Big Data Biomarker Discovery
… (GWAS) datasets. These data sets are often complex, poorly annotated or require complex domain knowledge to sensibly manage. These novel datasets provide a rare, multi-dimensional omics (proteomics, transcriptomics, and genomics) view of a single sample or patient. Previously, biologists …
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