Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Complement inhibition"”.
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Development and biophysical characterization of a hyaluronic acid – vitamin E conjugate as a subcutaneous delivery platform
… Coversin from the HAtoco nanogel demonstrated complement inhibition for at least 73 hours in vitro. Overall, HAtoco has demonstrated the ability to bind protein therapeutics in a reversible manner capable of prolonging their release in a therapeutically efficacious state.
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Cardioprotective treatment strategies
In myocardial ischemia-reperfusion (I/R) injury, complement activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective …
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Complement evasion strategies of human pathogens - the evolutionary arms race
Although the complement system, a pivotal component of innate immunty, is centrally involved in host defense against pathogens, its overactivation or deregulation may excessively amplify inflammation and contribute to immunopathology. Periodontitis, an oral infection-driven chronic inflammatory …
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Cervical Remodeling/ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells
… treatment for PTD. We tested the hypothesis that complement activation plays a role in cervical remodeling and PTD. We studied cervical remodeling at term.</p> <p>We studied two mouse models of inflammation-induced PTD. The first model was induced by vaginal administration of lipopolysaccharide …
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Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system
… I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The …