Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Compensatory pathways"”.
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Systems Biology Approaches for Elucidating Early ALS Disease Processes
… I present analyses aimed at discovering disease pathways and genes associated with ALS using systems biology approaches. In patients with the C9orf72 mutation, I use a network-based algorithm to identify disrupted pathways enriched for extracellular matrix organization and protein transport. …
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Investigating Cell-Type-Specific Vulnerability in Mitochondrial Disease Using Stem Cell-Derived Neuronal Models
… stress responses. Cortical neurons activated compensatory mechanisms such as mitochondrial remodelling and heat shock protein induction, while motor neurons showed increased apoptosis and inflammatory priming. In POLG mutant neurons, GABAergic interneurons exhibited a rigid, OXPHOS-dependent …
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The Role of Pyruvate Dehydrogenase in Cell Growth
… extracellular lipids. This work illustrates that compensatory pathways that sustain cell proliferation are activated during suppression of mitochondrial oxidation of glucose.
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Mechanisms Controlling the Segregation of Mitochondrial DNA Heteroplasmy
… the m.5024C>T mutation seem to mount a greater compensatory transcriptional response compared to their m.5019A>G counterparts. Finally, I explore the relationship between mtDNA heteroplasmy, copy number and the cell cycle. More specifically, making use of a fluorescent cell cycle reporter, I …