Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Compartment models"”.
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Modeling approaches to characterize the disposition of monoclonal antibodies
… on one hand, select the structure of classical compartment models and on the other hand, interpret mechanistically PK parameters. The mechanistic knowledge present in physiologically-based PK (PBPK) models is likely to support rational classical model selection and thus, a methodology to link …
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Bioaccumulation of trace metals in biota (algae and chironomids) from Kenyan saline lakes (Bogoria and Nakuru): evaluation and verification of two compartment toxicokinetic models
… lakes as biomonitors of trace metals. The use of compartment models as predictive tools in assessment environmental quality was also evaluated. The test organisms (Algae Arthrospira fusiformis and chironomids Lepotochironomous deribae) exhibited organism dependent and element specific metal uptake …
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A new way to do epidemic modeling
… broadly into the following categories: (a) compartment models which are interpretable but cannot capture complex effects and (b) agent based models which can capture varying ranges of complexity; but are generally non interpretable. In this thesis, we introduce another category for epidemic …
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Evaluation of spatial and temporal models to assess the bioaccumulation of trace metals in marine invertebrates
… experiments and analysed by means of two-compartment models. The model parameters obtained were verified with independent experimental data and interpreted in terms of the accumulation strategies. In a final step the sensitivity of C. crangon for biomonitoring purposes was evaluated by …
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STATIC AND DYNAMIC FORMS TO IDENTIFY DDI POTENTIAL AND SOURCES OF PHARMACOKINETIC VARIABILITY
… trial design to capture hydroxychloroquine 3-compartment pharmacokinetics by varying the sample size and sample collection timepoints in a population pharmacokinetic (PopPK) model. Understanding how co-administered drugs interact is critical for determining how one can impact the efficacy and …
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Quantifying the pathways modulated by deep brain stimulation for essential tremor using computational modeling
… developed patient-specific computational neuron models from three ET patients implanted with a Medtronic 3389 DBS lead. Multi-compartment models of Vim / Vc thalamocortical neurons and cerebellothalamic / medial lemniscal axonal afferents were simulated in the context of patient-specific …
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Design of drug delivery strategies based on well-stirred experiments
… vessel experiments that mimic one- and two-compartment pharmacokinetic models. A one-compartment model assumes that drug is evenly distributed in the body, which is represented by a beaker with an inlet and an outlet stream. In a two- compartment model, drug is distributed between the …
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Diffusion-weighted MRI of skeletal muscle: Estimation of microstructural parameters
… comparison of the LBM model with analytical two-compartment models as well as the completion of a global sensitivity study of the effects of microstructural and pulse parameters on the dMRI signal. The results from the sensitivity analysis allow for the creation of a polynomial meta-model, which …
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Using control surfaces to evaluate weighting coefficients for fast thermo-fluid reduced-order-modelling strategies
… and development efforts. <br/><br/>Aircraft compartments are packed with heat dissipating avionic cables and components, the thermal management of which is a primary concern for the reliable operation of aircraft systems. Therefore, there is a pressing need for fast thermo-fluid modelling …
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Use Of Dual Energy X-Ray Absorptiometry Measurements To Evaluate Total Body Volume When Compared To Air Displacement Plethysmography For Evaluating Body Composition In A Four Compartment Model
… using predicted body volume measurements in four-compartment body composition models. </p> <p>Methods: Subjects were tested on three devices designed for body composition metrics; DEXA for lean body mass, bone mineral content, and fat mass, BodPod for body volume, and a bioimpedance spectroscopy …
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Bioaccumulation and Toxicokinetics of Polycyclic Aromatic Compounds and Metals in Giant Floater Mussels (Pyganodon grandis) Exposed to a Simulated Diluted Bitumen Spill
… only focus on parent PACs. From first-order one-compartment models derived from nonlinear curve fitting of the accumulation phase or sequential modelling method, uptake (0.66 – 24.65 L g-1 day-1, n=87) and depuration (0.012 – 0.37 day-1, n=87) kinetic rate constants, as well as bioconcentration …
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Modelling and inference in active systems
… with microscopic scales, while epidemiological models operate on the scale of human populations. Using this, we apply methods from Bayesian inference to quantify the respective underlying uncertainties from stochastic trajectories alone. In the following, we briefly introduce the two parts of …
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Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens
… children. Moreover, population pharmacokinetics models were used to characterise lopinavir and nevirapine parameters. From the final models parameters were derived and were used to assess the relationship between lopinavir and nevirapine pharmacokinetics and genetic polymorphism relevant to both …
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Fate and behaviour of metformin and its transformation product guanylurea in soil-water systems
… source to microbes. Out of the six kinetic models used (single first order, Michaelis-Menten, logistic, logarithmic, Quiroga-Rosales-Romero (QSR) and autocatalytic models), the QSR and autocatalytic models predicted the degradation profiles of GUA and MET, respectively, capturing the …
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Pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds
… pharmacokinetic parameters were calculated with compartment models. Also the plasma protein binding capacity of the different bird species for flunixin, meloxicam and salicylic acid at three different concentrations was studied. Most bird species exhibited a rapid elimination of these drugs. …