Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Comparative modeling"”.
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Comparative modeling of mainly-beta proteins by profile wrapping
… thesis introduces BetaWrapPro, a program for comparative modeling of the parallel -helix fold. By estimating pairwise [beta]-strand interaction probabilities, a profile of the target sequence is aligned, or "wrapped," onto al abstract supersecondary structural template. This wrapping procedure …
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Bioinformatic studies of small disulphide-rich proteins (SDPs)
… and implemented specifically for the automated comparative modeling of SDPs. A specific family of SDPs, potato type II proteinase inhibitor family (Pot II) was studied. The comprehensive analyses of Pot II family characterized the conserved patterns in 3D structure, protein sequence and gene …
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Evolution of Transcription in Archaea and the Early-Diverging Eukaryote, Giardia Lamblia
Comparative analyses are at the core of modern biology, providing insight into the evolution of life and specific cellular systems. This thesis analyzes transcription systems in Archaea and Eucarya in an effort to understand the evolution of this fundamental cellular process. Projects span from …
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Improved Constrained Global Optimization for Estimating Molecular Structure From Atomic Distances
… predicting protein structures in the context of comparative modeling.</p>
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The mechanisms underlying convergent evolution in the plumage patterns of birds
… trajectory of pattern evolution with Bayesian comparative modeling there was evidence for developmental constraint in pattern evolution. Adaptive explanations may also result in convergence. Cuckoo-hawk mimicry has been demonstrated in the common cuckoo (Cuculus canorus) and the Eurasian …
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Application of the Statistical Energy Landscape Theory to Protein Structure Prediction
… results place us among the top three groups in comparative modeling. Using this energy function, we predicted the structures of four archaeal adenylate kinases that had less than 17% sequence similarity to any known structure. These predicted structures were then used to study the sources of …
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A numerical study on parameters affecting boric acid transport and chemistry within fuel corrosion deposits during crud induced power shift
… consistent with published plant observations and comparative modeling studies elsewhere.
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Targeting protein kinases to manage or prevent Alzheimer’s disease
… in AD pathophysiology.</p> <p>In our studies, comparative modeling was performed to construct 3D models for kinases whose crystal structures have not yet been identified. The information from structurally similar proteins was used to define the amino acid residues in the ATP binding site as …
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Modeling the Dissolution of Immiscible Contaminants in Groundwater for Decision Support
… remediation strategies, but quantitative modeling efforts are inherently subject to multiple uncertainties. These include unknown residual amounts of non-aqueous phase liquids (NAPL) and source zone dimensions, inconsistent historical monitoring of contaminant mass discharge, and the …