Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 203 for “"Comparative Genomics"”.
-
Algorithms in comparative genomics
The field of comparative genomics is abundant with problems of interest to computer scientists. In this thesis, the author presents solutions to three contemporary problems: obtaining better alignments for phylogeny reconstruction, identifying related RNA sequences in genomes, and ranking Single …
-
Comparative genomics of Bifidobacteria
… in the adaptation to the gut environment. This comparative genomic analysis also determined a pool of ortholog functions used to infer their phylogenetic relationship, thereby providing a more robust approach compared to that based solely on the16S rRNA-encoding gene. The genome sequence of an …
-
Mammalian comparative genomics and epigenomics
… processes that have acted on the genome using comparative sequence analysis. We generate high quality draft genome sequences of the chimpanzee, the dog and the opossum. These species share a last common ancestor with humans approximately 6 million, 80 million and 140 million years ago, …
-
Comparative genomics of early animal evolution
The explosion of genomics permits investigations into the origin and early evolution of the Metazoa at the molecular level. In this thesis, I am particularly interested in investigating the molecular foundation of the animal senses (i.e. how animals perceive their world). To understand the …
-
Computational comparative genomics : genes, regulation, evolution
… to coordinate the expression of these genes. Comparative genome analysis of related species provides a general approach for identifying these functional elements, by virtue of their stronger conservation across evolutionary time. In this thesis we address key issues in the comparative analysis …
-
On Two Problems in Comparative Genomics of Eukaryotes
… whole-genome sequencing allows us to use novel comparative methods to explore the genetic bases for traits of interest. Here, I present two case studies of such methods applied to eukaryote genomes. The first study regards the evolution of longevity in the mammalian proteome. Evolutionary theory …
-
Computational Prediction of Functional Elements through Comparative Genomics
… increasing number of species being sequenced, comparative genomes, which compares the sequences from multiple species at varying evolutionary distances, has now merged as a very powerful approach for identifying variety types of functional elements, such as protein coding genes, transcriptional …
-
Comparative genomics of chromosomal rearrangements in malaria mosquitoes
To better understand the evolutionary dynamics of chromosomal inversions, a physical map for an Asian malaria vector, Anopheles stephensi, was created and compared with the maps of the major African malaria vectors A. gambiae and A. funestus No interchromosomal transposition was observed between A. …
-
Comparative Genomics of Selected Species of Gram-Negative Bacteria
Investigation of genomic diversity can provide insight into the evolutionary history of bacterial species. However, complete genome sequencing is not yet practical for large strain collections at the beginning of this project. In this project PCR-based methods to investigate the genomic diversity …
-
Ecology, diversity and comparative genomics of oceanic cyanobacterial viruses
The marine cyanobacteria Prochlorococcus and Synechococcus are numerically dominant primary producers in the oceans. Each genera consists of multiple physiologically and genetically distinct groups (termed "ecotypes" in Prochlorococcus). Cyanobacterial viruses (cyanophages) that infect …
-
Identification and characterization of conserved regulatory elements by comparative genomics
The aim of this study is to use fugu to identify conserved noncoding elements (CNEs) in genes expressing in the human forebrain, and to characterize selected CNEs in transgenic mice. To this end, genomic sequences for 50 human genes were aligned with their orthologous sequences in mouse and fugu. …
-
Hox Targeting in Vertebrate Forelimb Induction: Expression and Comparative Genomics
… and Fgf10</em>) have been predicted through comparative genomics, including the use of sequence alignment, phylogenetic footprinting, and related analyses. We have also used comparative genomics to predict potential Lmx1b core binding sites in the Emx2 gene. Both Lmxlb and <em>Emx2</em> are …
-
Comparative Genomics Insights into Speciation and Evolution of Hawaiian Drosophila
… adaptive radiation and speciation, and genomics and bioinformatics offer new approaches for studying these fundamental processes. The mode of speciation should have profound impacts on the genomic architecture and patterns of reproductive isolation of new species. The Hawaiian Drosophila …
-
Insight Into Human Brain Evolution Through Phylogenetic Analysis And Comparative Genomics
… brain expansion among primates, we implement a comparative genomics approach and sequenced the brain transcriptome of the second most encephalized primate, the capuchin monkey (Cebus). We then test for similar patterns of adaptive evolution on the capuchin monkey and human lineages and …
-
Defining the tropism of Listeria monocytogenes using a comparative genomics approach
… for clinical, food and environmental niches. Comparative genomic techniques, namely mixed-genome microarrays, dot-blot hybridization and suppressive subtractive hybridization were used to compare the genomes of L. monocytogenes isolates of different serotypes from a variety of different …
-
COMPARATIVE GENOMICS OF CHEMOSENSORY GENE FAMILIES AMONG MEMBERS OF THE HELIOTHINAE
Insect chemosensory systems play crucial roles in the perception of chemical signals that regulate sexual behaviors and odors that mediate insect-host plant interactions. These processes, mate-finding and acceptance, as well as host plant identification and use, strongly contribute to …
-
Modeling Sequence Uncertainty in Comparative Genomics with a Probabilistic DNA Representation
… contributing to pervasive reference biases in genomics. Graph pangenomes have recently emerged to address these limitations by representing genetic variation across populations as bidirected graphs. While promising, these approaches are still developing and are not yet fully integrated with …
Page 1 of 11