Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Comparative Genomic Hybridization"”.
-
High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma
… Here we used high-density array-based comparative genomic hybridization to examine the genomes of RMS to identify common programs that drive tumor pathogenesis.
-
Genetic Imbalances in Endometriosis Detected by Oligonucleotide-Array Based Comparative Genomic Hybridization
… was analyzed using oligonucleotide based array comparative genomic hybridization. The results suggest that an addition on chromosome 17p13.3 may play a role in the biological mechanisms involved in endometriosis as it was identified in 75% of the DNA samples obtained from the peripheral blood …
-
Genomic Approaches to Congenital Genitourinary Disorders
… The goal of this research was to use both array-comparative genomic hybridization and whole exome sequencing to identify causative variants and candidate genes for PBS, persistent cloaca, and DSD. Sequencing the exomes of two PBS brothers identified a missense mutation in Filamin A and functional …
-
Genome sequence of the hyperinvasive Campylobacter jejuni strains
… of the hyperinvasive C. jejuni was performed by comparative genomic hybridization (CGH) against four low invasive C. jejuni strains. A group of 67 genes were identified as being present or highly divergent/absent in the hyperinvasive versus low invasive C. jejuni strains. Of these, nine genes …
-
The Analysis of the MCF7 Cancer Model System and the Effects of 5-AZA-2'-Deoxycytidine Treatment on the Chromantin State Using a Novel Microarray-Based Technology for High Resolution Global Chromatin State Measurement
… using chromatin fractionation. By probing with a comparative genomic hybridization-style microarray, the chromatin condensation state of thousands of individual loci in an MCF7 tumor model cell line was determined and correlated with transcriptional activity. The chromatin array showed a …
-
Reprogramming human somatic cells to pluripotency using RNA
… neurons in vitro. Genetic analysis using array comparative genomic hybridization with an 8.9kb median probe spacing demonstrated that RNA reprogramming can yield lines free of copy number variations. The very high efficiency of this technique allowed us to reprogram single adult fibroblasts to …
-
Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… The aim of this study was to explore for novel genomic biomarker predicting hepatocellular carcinoma (HCC) prognosis by integrative analysis of DNA copy number aberrations (CNAs) and gene expression profiles. Array comparative genomic hybridization and expression array were performed on 45 and …
-
Comparative analysis of Cronobactor sp. with respect to genomic diversity and physiology
… and plasmids pESA2 (31 kb) and pESA3 (131 kb). Comparative genomic hybridization (CGH) was undertaken on five C. sakazakii strains, and representatives of four other Cronobacter species. CGH highlighted 15 clusters of genes that were divergent or absent in more than half of the tested strains.
-
Genomic diversity in naturally transformable Streptococcus pneumoniae
… and, “invasion.” In order to do this, microarray comparative genomic hybridization (CGH) has been utilized to compare DNA from a variety of pneumococcal isolates chosen from 10 diverse serotypes and Multilocus Sequence Types and from clinically relevant serotypes and sequence types (particularly …
-
An evaluation of genomic factors and their importance in etiopathogenesis of congenital heart diseases /
… is to determine and evaluate the importance of genomic variants and of candidate genes in etiopathogenesis of congenital heart diseases. This piece of research was carried out on 132 subjects with CHDs. Phenotypic heterogeneity and complexity is typical to CHDs. Single nucleotide polymorphism – …
-
Genominių veiksnių įvertinimas ir reikšmė įgimtų širdies ydų etiopatogenezėje /
… is to determine and evaluate the importance of genomic variants and of candidate genes in etiopathogenesis of congenital heart diseases. This piece of research was carried out on 132 subjects with CHDs. Phenotypic heterogeneity and complexity is typical to CHDs. Single nucleotide polymorphism – …
-
Current Practices and Perspectives of Genetic Counselors and Reproductive Endocrinologists Regarding Transfer of Mosaic Embryos
… testing for aneuploidy (PGT-A) from array comparative genomic hybridization to next generation sequencing, mosaic embryos are being identified more readily. Given the limited clinical guidance and information regarding outcomes after the transfer of mosaic embryos (TME), a mosaic test …
-
Genetic Profiling in Soft Tissue Sarcoma
… pleomorphic STS. Study IV applied array-based comparative genomic hybridization in MFH and LMS, and demonstrated extensive genetic complexity with multiple recurrent gains and losses, novel amplifications and homozygous deletions. Losses in chromosomal regions 6q14 and 7q36 provided prognostic …
-
Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam
… genome-wide DNA microarray (e.g. microarray comparative genomic hybridization (aCGH)) is considered as the first-tier screen for genetic aberrations in autistic children, albeit with a limited success (around 10% in studies primarily based on patients of Caucasian origin). Currently, there is …
-
Developing and Optimizing Conditions for Single Cell Genetic Analysis
… sufficient DNA for eventual use in array comparative genomic hybridization (CGH) to determine chromosome complement. Sporadic MDA results occurred at the single cell level; larger cell quantities consistently amplified. MDA can generate sufficient quantities of DNA for array CGH. …
-
Genomic diversity of Lactobacillus salivarius
… to have an understanding of the level of genomic diversity present in this species. Comparative genomic hybridization (CGH) and multilocus sequence typing (MLST) were employed to assess the level of genomic diversity in L. salivarius. The wellcharacterised probiotic strains L. salivarius …
-
Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia
… DNA copy number variations: CNVs), defined as genomic sequences that are polymorphic in copy number and range in length from 1,000 to several million base pairs, were largely uncharacterized in inbred mice. We developed a computational approach, Washington University Hidden Markov Model: …
-
Analysis of metazoan DNA replication initiation using Drosophila gene amplification as a model system
… We mapped all follicle cell amplicons using a comparative genomic hybridization strategy and identified two new amplicons. We determined the precise localization of the origin recognition complex (ORC) on a genome-wide level and observed that, at the start of synchronous amplification, ORC …
-
Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics
… least two primary STS and we applied array-based comparative genomic hybridization to study the genetic profiles of these tumors. Cluster anaysis and comparison between the genetic profiles suggested that 8 cases represented second primary STS, whereas 5 cases likely represented soft tissue …
-
Screening and Functional Study of the Genes inducing Malignant Degeneration of Neurofibromatosis Type 1
… in NF1 tumor cells, we carried out CGH(comparative genomic hybridization) array in NF1 cells, but no genetic alterations have been found in the NF1 cells. We have cloned and sequenced 20 DEGs that showed clear differences in expression pattern among cell types. We performed a validation …
Page 1 of 2