Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Companion Diagnostics"”.
-
Optimal Contract Design for Co-development of Companion Diagnostics
As the number of new drugs requiring companion diagnostics rises, more and more partnerships are formed between drug and diagnostics manufacturers to develop the necessary companion diagnostic. An increasingly significant issue is that of the optimal revenue/profit sharing or compensation schemes …
-
The application of genomic technologies to cancer and companion diagnostics.
… RNA-seq, ChIP-seq, microarray, ERBB2, companion diagnostic.
-
Fulfilling the promise of targeted therapeutics in oncology via companion diagnostics : a perspective on pipeline trends and co-development strategies
… the notion that contemporaneously developed companion diagnostics (CDx) could lead to more efficacious use of a cancer therapeutic in a selected population. Despite a gap of 12 years, the recent approvals of Zelboraf and Xalkori in quick succession by the FDA are a testament to the fact that …
-
Assessing the economic case for stratified medicine
… favor the joint development of therapeutics and companion diagnostics. I hypothesize that predictive biomarkers can generate economic value in drug development by increasing success rates. I construct an economic model of the development of a hypothetical new therapy, and devote particular …
-
Bridging the "Valley of Death" in stratified medicine : commercializing molecular diagnostics in oncology
Historically, the development of molecular companion diagnostics in oncology has underwhelmed the expectation of the medical field since the successful mapping of the human genome a decade ago. There have been several highly successful developments (Her2-neu, Genomic Health, etc.), but not the …
-
Near Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therapy
… that can be used for ChoKa measurement, as companion diagnostics to validate new ChoKa inhibitors, and as therapeutically-effective inhibitors of choline metabolism.
-
High sensitivity DNA detection using gold nanoparticles and conducting polymers
… by issues ranging from personalized medicine to companion diagnostics such as antibiotic selection for infectious diseases. In order to enhance the sensitivity of electrochemical detection of DNA, novel conducting polymer- metal nanoparticle composites have been created. An electrode modified …
-
Organizational Antecedents to the Implementation of Precision Medicine: Overcoming Resistance to Change
Precision medicine (PM) is “the treatment and prevention of disease that takes into account individual variability in genes, environment, and lifestyle for each person” (NIH, 2015). PM was poised to transform clinical practice in 2003 when the Human Genome Project reached completion but resistance …